Prognosis and New Predictors of Early Left-Ventricular Thrombus Following ST-Elevation Myocardial Infarction

Qian Zhang,1 Zhongfan Zhang,1 Lina Jin,2 Chengbing Wang,3 Haikuo Zheng,1 Shouping Li,1 Miao Yu,1 Daoyuan Si,1 Wenqi Zhang1 1Department of Cardiology, China-Japan Union Hospital of Jilin University, Jilin Provincial Molecular Biology Research Center for Precision Medicine of Major Cardiovascular Dise...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Zhang Q, Zhang Z, Jin L, Wang C, Zheng H, Li S, Yu M, Si D, Zhang W
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	left ventricular thrombus st-segment elevation myocardial infarction prognosis risk factors Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/4051426b6ced4b399e15624d7d7de5c4
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4051426b6ced4b399e15624d7d7de5c4
record_format	dspace
spelling	oai:doaj.org-article:4051426b6ced4b399e15624d7d7de5c42021-11-30T18:50:36ZPrognosis and New Predictors of Early Left-Ventricular Thrombus Following ST-Elevation Myocardial Infarction1178-7074https://doaj.org/article/4051426b6ced4b399e15624d7d7de5c42021-11-01T00:00:00Zhttps://www.dovepress.com/prognosis-and-new-predictors-of-early-left-ventricular-thrombus-follow-peer-reviewed-fulltext-article-IJGMhttps://doaj.org/toc/1178-7074Qian Zhang,1 Zhongfan Zhang,1 Lina Jin,2 Chengbing Wang,3 Haikuo Zheng,1 Shouping Li,1 Miao Yu,1 Daoyuan Si,1 Wenqi Zhang1 1Department of Cardiology, China-Japan Union Hospital of Jilin University, Jilin Provincial Molecular Biology Research Center for Precision Medicine of Major Cardiovascular Disease, Changchun, People’s Republic of China; 2Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, Jilin, People’s Republic of China; 3Department of Neurology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, People’s Republic of ChinaCorrespondence: Daoyuan Si;Wenqi ZhangDepartment of Cardiology, China-Japan Union Hospital of Jilin University, Xiantai Street No. 126, Changchun, Jilin, People’s Republic of ChinaTel +86 135 78949866; +86 136 44407485Fax +86 431 84995233; +86 431 84995259Email sidaoyuan@jlu.edu.cn; wenqi@jlu.edu.cnObjective: In the current era of primary percutaneous coronary intervention (PPCI), the prognosis of the left ventricular thrombus (LVT) is not well assessed.Methods: We performed a retrospective, single-center study of 1305 consecutive ST-segment-elevation myocardial infarction (STEMI) patients treated with PPCI. During a mean period of 27 months of follow-up, the major adverse cardiovascular and cerebrovascular events (MACCE) were recorded.Results: The incidence of LVT (n = 47) was 3.60%. The independent risk factors of LVT included anterior STEMI, left ventricular (LV) aneurysm, reduced LV ejection fraction (LVEF), dilated LV end-diastolic dimension (LVEDD), and delayed door-to-balloon time (DTBT). During follow-up, LVT was an independent risk factor for MACCE [hazard ratio (HR)=3.46; 95% confidence interval (CI) = 2.23– 3.38; P < 0.01]. Patients with LVT were more likely to have the following complications: heart failure (P < 0.001), embolic events (P = 0.034), and all-cause mortality (P = 0.020). Notably, the regression of LVT was not independently associated with those three adverse events (P > 0.05).Conclusion: In the era of PPCI, the presence of early LVT following STEMI was associated with adverse events. Furthermore, the prognosis of patients with LVT did not improve even if the LVT regressed. LVT was likely a generalized indicator of impaired cardiac performance, rather than the cause. This indicated that prophylactic therapy and identifying individuals with a high risk of developing LVT were of substantial importance.Keywords: left ventricular thrombus, ST-segment elevation myocardial infarction, prognosis, risk factorsZhang QZhang ZJin LWang CZheng HLi SYu MSi DZhang WDove Medical Pressarticleleft ventricular thrombusst-segment elevation myocardial infarctionprognosisrisk factorsMedicine (General)R5-920ENInternational Journal of General Medicine, Vol Volume 14, Pp 8991-9000 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	left ventricular thrombus st-segment elevation myocardial infarction prognosis risk factors Medicine (General) R5-920
spellingShingle	left ventricular thrombus st-segment elevation myocardial infarction prognosis risk factors Medicine (General) R5-920 Zhang Q Zhang Z Jin L Wang C Zheng H Li S Yu M Si D Zhang W Prognosis and New Predictors of Early Left-Ventricular Thrombus Following ST-Elevation Myocardial Infarction
description	Qian Zhang,1 Zhongfan Zhang,1 Lina Jin,2 Chengbing Wang,3 Haikuo Zheng,1 Shouping Li,1 Miao Yu,1 Daoyuan Si,1 Wenqi Zhang1 1Department of Cardiology, China-Japan Union Hospital of Jilin University, Jilin Provincial Molecular Biology Research Center for Precision Medicine of Major Cardiovascular Disease, Changchun, People’s Republic of China; 2Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, Jilin, People’s Republic of China; 3Department of Neurology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, People’s Republic of ChinaCorrespondence: Daoyuan Si;Wenqi ZhangDepartment of Cardiology, China-Japan Union Hospital of Jilin University, Xiantai Street No. 126, Changchun, Jilin, People’s Republic of ChinaTel +86 135 78949866; +86 136 44407485Fax +86 431 84995233; +86 431 84995259Email sidaoyuan@jlu.edu.cn; wenqi@jlu.edu.cnObjective: In the current era of primary percutaneous coronary intervention (PPCI), the prognosis of the left ventricular thrombus (LVT) is not well assessed.Methods: We performed a retrospective, single-center study of 1305 consecutive ST-segment-elevation myocardial infarction (STEMI) patients treated with PPCI. During a mean period of 27 months of follow-up, the major adverse cardiovascular and cerebrovascular events (MACCE) were recorded.Results: The incidence of LVT (n = 47) was 3.60%. The independent risk factors of LVT included anterior STEMI, left ventricular (LV) aneurysm, reduced LV ejection fraction (LVEF), dilated LV end-diastolic dimension (LVEDD), and delayed door-to-balloon time (DTBT). During follow-up, LVT was an independent risk factor for MACCE [hazard ratio (HR)=3.46; 95% confidence interval (CI) = 2.23– 3.38; P < 0.01]. Patients with LVT were more likely to have the following complications: heart failure (P < 0.001), embolic events (P = 0.034), and all-cause mortality (P = 0.020). Notably, the regression of LVT was not independently associated with those three adverse events (P > 0.05).Conclusion: In the era of PPCI, the presence of early LVT following STEMI was associated with adverse events. Furthermore, the prognosis of patients with LVT did not improve even if the LVT regressed. LVT was likely a generalized indicator of impaired cardiac performance, rather than the cause. This indicated that prophylactic therapy and identifying individuals with a high risk of developing LVT were of substantial importance.Keywords: left ventricular thrombus, ST-segment elevation myocardial infarction, prognosis, risk factors
format	article
author	Zhang Q Zhang Z Jin L Wang C Zheng H Li S Yu M Si D Zhang W
author_facet	Zhang Q Zhang Z Jin L Wang C Zheng H Li S Yu M Si D Zhang W
author_sort	Zhang Q
title	Prognosis and New Predictors of Early Left-Ventricular Thrombus Following ST-Elevation Myocardial Infarction
title_short	Prognosis and New Predictors of Early Left-Ventricular Thrombus Following ST-Elevation Myocardial Infarction
title_full	Prognosis and New Predictors of Early Left-Ventricular Thrombus Following ST-Elevation Myocardial Infarction
title_fullStr	Prognosis and New Predictors of Early Left-Ventricular Thrombus Following ST-Elevation Myocardial Infarction
title_full_unstemmed	Prognosis and New Predictors of Early Left-Ventricular Thrombus Following ST-Elevation Myocardial Infarction
title_sort	prognosis and new predictors of early left-ventricular thrombus following st-elevation myocardial infarction
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/4051426b6ced4b399e15624d7d7de5c4
work_keys_str_mv	AT zhangq prognosisandnewpredictorsofearlyleftventricularthrombusfollowingstelevationmyocardialinfarction AT zhangz prognosisandnewpredictorsofearlyleftventricularthrombusfollowingstelevationmyocardialinfarction AT jinl prognosisandnewpredictorsofearlyleftventricularthrombusfollowingstelevationmyocardialinfarction AT wangc prognosisandnewpredictorsofearlyleftventricularthrombusfollowingstelevationmyocardialinfarction AT zhengh prognosisandnewpredictorsofearlyleftventricularthrombusfollowingstelevationmyocardialinfarction AT lis prognosisandnewpredictorsofearlyleftventricularthrombusfollowingstelevationmyocardialinfarction AT yum prognosisandnewpredictorsofearlyleftventricularthrombusfollowingstelevationmyocardialinfarction AT sid prognosisandnewpredictorsofearlyleftventricularthrombusfollowingstelevationmyocardialinfarction AT zhangw prognosisandnewpredictorsofearlyleftventricularthrombusfollowingstelevationmyocardialinfarction
_version_	1718406317702381568

Prognosis and New Predictors of Early Left-Ventricular Thrombus Following ST-Elevation Myocardial Infarction

Ejemplares similares