A high-throughput screening and computation platform for identifying synthetic promoters with enhanced cell-state specificity (SPECS)
Synthetic promoters can be superior to native ones but the design is challenging without knowledge of gene regulation. Here the authors develop a pipeline that allows for screening a synthetic promoter library to identify high performance promoters in potentially any given cell state of interest.
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| Lenguaje: | EN |
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Nature Portfolio
2019
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| Acceso en línea: | https://doaj.org/article/4058b7f205214aa99e7ffdf21a5903d9 |
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oai:doaj.org-article:4058b7f205214aa99e7ffdf21a5903d92021-12-02T15:35:47ZA high-throughput screening and computation platform for identifying synthetic promoters with enhanced cell-state specificity (SPECS)10.1038/s41467-019-10912-82041-1723https://doaj.org/article/4058b7f205214aa99e7ffdf21a5903d92019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10912-8https://doaj.org/toc/2041-1723Synthetic promoters can be superior to native ones but the design is challenging without knowledge of gene regulation. Here the authors develop a pipeline that allows for screening a synthetic promoter library to identify high performance promoters in potentially any given cell state of interest.Ming-Ru WuLior NissimDoron StuppErez PeryAdina Binder-NissimKaren WeisingerCasper EnghuusSebastian R. PalaciosMelissa HumphreyZhizhuo ZhangEva Maria NovoaManolis KellisRon WeissSamuel D. RabkinYuval TabachTimothy K. LuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Ming-Ru Wu Lior Nissim Doron Stupp Erez Pery Adina Binder-Nissim Karen Weisinger Casper Enghuus Sebastian R. Palacios Melissa Humphrey Zhizhuo Zhang Eva Maria Novoa Manolis Kellis Ron Weiss Samuel D. Rabkin Yuval Tabach Timothy K. Lu A high-throughput screening and computation platform for identifying synthetic promoters with enhanced cell-state specificity (SPECS) |
| description |
Synthetic promoters can be superior to native ones but the design is challenging without knowledge of gene regulation. Here the authors develop a pipeline that allows for screening a synthetic promoter library to identify high performance promoters in potentially any given cell state of interest. |
| format |
article |
| author |
Ming-Ru Wu Lior Nissim Doron Stupp Erez Pery Adina Binder-Nissim Karen Weisinger Casper Enghuus Sebastian R. Palacios Melissa Humphrey Zhizhuo Zhang Eva Maria Novoa Manolis Kellis Ron Weiss Samuel D. Rabkin Yuval Tabach Timothy K. Lu |
| author_facet |
Ming-Ru Wu Lior Nissim Doron Stupp Erez Pery Adina Binder-Nissim Karen Weisinger Casper Enghuus Sebastian R. Palacios Melissa Humphrey Zhizhuo Zhang Eva Maria Novoa Manolis Kellis Ron Weiss Samuel D. Rabkin Yuval Tabach Timothy K. Lu |
| author_sort |
Ming-Ru Wu |
| title |
A high-throughput screening and computation platform for identifying synthetic promoters with enhanced cell-state specificity (SPECS) |
| title_short |
A high-throughput screening and computation platform for identifying synthetic promoters with enhanced cell-state specificity (SPECS) |
| title_full |
A high-throughput screening and computation platform for identifying synthetic promoters with enhanced cell-state specificity (SPECS) |
| title_fullStr |
A high-throughput screening and computation platform for identifying synthetic promoters with enhanced cell-state specificity (SPECS) |
| title_full_unstemmed |
A high-throughput screening and computation platform for identifying synthetic promoters with enhanced cell-state specificity (SPECS) |
| title_sort |
high-throughput screening and computation platform for identifying synthetic promoters with enhanced cell-state specificity (specs) |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/4058b7f205214aa99e7ffdf21a5903d9 |
| work_keys_str_mv |
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