A high-throughput screening and computation platform for identifying synthetic promoters with enhanced cell-state specificity (SPECS)

A high-throughput screening and computation platform for identifying synthetic promoters with enhanced cell-state specificity (SPECS)

Synthetic promoters can be superior to native ones but the design is challenging without knowledge of gene regulation. Here the authors develop a pipeline that allows for screening a synthetic promoter library to identify high performance promoters in potentially any given cell state of interest.

Guardado en:
Detalles Bibliográficos
Autores principales: Ming-Ru Wu, Lior Nissim, Doron Stupp, Erez Pery, Adina Binder-Nissim, Karen Weisinger, Casper Enghuus, Sebastian R. Palacios, Melissa Humphrey, Zhizhuo Zhang, Eva Maria Novoa, Manolis Kellis, Ron Weiss, Samuel D. Rabkin, Yuval Tabach, Timothy K. Lu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/4058b7f205214aa99e7ffdf21a5903d9
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Internet

https://doaj.org/article/4058b7f205214aa99e7ffdf21a5903d9

Ejemplares similares