Communication impairments in mice lacking Shank1: reduced levels of ultrasonic vocalizations and scent marking behavior.

Autism is a neurodevelopmental disorder with a strong genetic component. Core symptoms are abnormal reciprocal social interactions, qualitative impairments in communication, and repetitive and stereotyped patterns of behavior with restricted interests. Candidate genes for autism include the SHANK ge...

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Autores principales:	Markus Wöhr, Florence I Roullet, Albert Y Hung, Morgan Sheng, Jacqueline N Crawley
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4059565f040041e597f0906290f714dd
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spelling	oai:doaj.org-article:4059565f040041e597f0906290f714dd2021-11-18T06:52:20ZCommunication impairments in mice lacking Shank1: reduced levels of ultrasonic vocalizations and scent marking behavior.1932-620310.1371/journal.pone.0020631https://doaj.org/article/4059565f040041e597f0906290f714dd2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21695253/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Autism is a neurodevelopmental disorder with a strong genetic component. Core symptoms are abnormal reciprocal social interactions, qualitative impairments in communication, and repetitive and stereotyped patterns of behavior with restricted interests. Candidate genes for autism include the SHANK gene family, as mutations in SHANK2 and SHANK3 have been detected in several autistic individuals. SHANK genes code for a family of scaffolding proteins located in the postsynaptic density of excitatory synapses. To test the hypothesis that a mutation in SHANK1 contributes to the symptoms of autism, we evaluated Shank1(-/-) null mutant mice for behavioral phenotypes with relevance to autism, focusing on social communication. Ultrasonic vocalizations and the deposition of scent marks appear to be two major modes of mouse communication. Our findings revealed evidence for low levels of ultrasonic vocalizations and scent marks in Shank1(-/-) mice as compared to wildtype Shank1(+/+) littermate controls. Shank1(-/-) pups emitted fewer vocalizations than Shank1(+/+) pups when isolated from mother and littermates. In adulthood, genotype affected scent marking behavior in the presence of female urinary pheromones. Adult Shank1(-/-) males deposited fewer scent marks in proximity to female urine than Shank1(+/+) males. Call emission in response to female urinary pheromones also differed between genotypes. Shank1(+/+) mice changed their calling pattern dependent on previous female interactions, while Shank1(-/-) mice were unaffected, indicating a failure of Shank1(-/-) males to learn from a social experience. The reduced levels of ultrasonic vocalizations and scent marking behavior in Shank1(-/-) mice are consistent with a phenotype relevant to social communication deficits in autism.Markus WöhrFlorence I RoulletAlbert Y HungMorgan ShengJacqueline N CrawleyPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 6, p e20631 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Markus Wöhr Florence I Roullet Albert Y Hung Morgan Sheng Jacqueline N Crawley Communication impairments in mice lacking Shank1: reduced levels of ultrasonic vocalizations and scent marking behavior.
description	Autism is a neurodevelopmental disorder with a strong genetic component. Core symptoms are abnormal reciprocal social interactions, qualitative impairments in communication, and repetitive and stereotyped patterns of behavior with restricted interests. Candidate genes for autism include the SHANK gene family, as mutations in SHANK2 and SHANK3 have been detected in several autistic individuals. SHANK genes code for a family of scaffolding proteins located in the postsynaptic density of excitatory synapses. To test the hypothesis that a mutation in SHANK1 contributes to the symptoms of autism, we evaluated Shank1(-/-) null mutant mice for behavioral phenotypes with relevance to autism, focusing on social communication. Ultrasonic vocalizations and the deposition of scent marks appear to be two major modes of mouse communication. Our findings revealed evidence for low levels of ultrasonic vocalizations and scent marks in Shank1(-/-) mice as compared to wildtype Shank1(+/+) littermate controls. Shank1(-/-) pups emitted fewer vocalizations than Shank1(+/+) pups when isolated from mother and littermates. In adulthood, genotype affected scent marking behavior in the presence of female urinary pheromones. Adult Shank1(-/-) males deposited fewer scent marks in proximity to female urine than Shank1(+/+) males. Call emission in response to female urinary pheromones also differed between genotypes. Shank1(+/+) mice changed their calling pattern dependent on previous female interactions, while Shank1(-/-) mice were unaffected, indicating a failure of Shank1(-/-) males to learn from a social experience. The reduced levels of ultrasonic vocalizations and scent marking behavior in Shank1(-/-) mice are consistent with a phenotype relevant to social communication deficits in autism.
format	article
author	Markus Wöhr Florence I Roullet Albert Y Hung Morgan Sheng Jacqueline N Crawley
author_facet	Markus Wöhr Florence I Roullet Albert Y Hung Morgan Sheng Jacqueline N Crawley
author_sort	Markus Wöhr
title	Communication impairments in mice lacking Shank1: reduced levels of ultrasonic vocalizations and scent marking behavior.
title_short	Communication impairments in mice lacking Shank1: reduced levels of ultrasonic vocalizations and scent marking behavior.
title_full	Communication impairments in mice lacking Shank1: reduced levels of ultrasonic vocalizations and scent marking behavior.
title_fullStr	Communication impairments in mice lacking Shank1: reduced levels of ultrasonic vocalizations and scent marking behavior.
title_full_unstemmed	Communication impairments in mice lacking Shank1: reduced levels of ultrasonic vocalizations and scent marking behavior.
title_sort	communication impairments in mice lacking shank1: reduced levels of ultrasonic vocalizations and scent marking behavior.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/4059565f040041e597f0906290f714dd
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Communication impairments in mice lacking Shank1: reduced levels of ultrasonic vocalizations and scent marking behavior.

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