Pemphigus—The Crux of Clinics, Research, and Treatment during the COVID-19 Pandemic

Pemphigus is a rare autoimmune disease characterised by the production of pathogenic autoantibodies in response to different desmosome proteins. The pathophysiological process leads to the development of blisters and erosions on mucosal and/or skin surfaces. The classical clinical variants of pemphi...

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Autores principales:	Branka Marinović, Joško Miše, Ines Lakoš Jukić, Zrinka Bukvić Mokos
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	pemphigus desmoglein rituximab immunodermatology COVID-19 SARS-CoV-2 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/405b8992aae6401696d41ee5350fae14
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spelling	oai:doaj.org-article:405b8992aae6401696d41ee5350fae142021-11-25T16:48:59ZPemphigus—The Crux of Clinics, Research, and Treatment during the COVID-19 Pandemic10.3390/biomedicines91115552227-9059https://doaj.org/article/405b8992aae6401696d41ee5350fae142021-10-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1555https://doaj.org/toc/2227-9059Pemphigus is a rare autoimmune disease characterised by the production of pathogenic autoantibodies in response to different desmosome proteins. The pathophysiological process leads to the development of blisters and erosions on mucosal and/or skin surfaces. The classical clinical variants of pemphigus are pemphigus vulgaris and pemphigus foliaceus. A diagnostic delay is very common in pemphigus, especially among patients with mucosal involvement. However, in recent years we have witnessed considerably fewer patients with extensive mucocutaneous manifestations, since patients with oral lesions are referred to dermatologists to start the treatment much sooner than they had been previously. Among non-classical variants of pemphigus, unusual cases with discrepancies between autoantibody profiles and clinics challenge the “desmoglein compensation theory”. The identification of several other autoantigens that perform a role in the pathogenesis of different variants of pemphigus will progress immunodermatology towards an approach that will determine personalized pemphigus subtypes for each patient. Comorbidities among patients are primarily associated with the prolonged use of corticosteroids and other immunosuppressive agents. The SARS-CoV-2 pandemic raised concerns regarding the immunosuppressive effects of treatment and the risk of a more complicated COVID-19 infection, as well as on the ability to develop an adequate vaccine response.Branka MarinovićJoško MišeInes Lakoš JukićZrinka Bukvić MokosMDPI AGarticlepemphigusdesmogleinrituximabimmunodermatologyCOVID-19SARS-CoV-2Biology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1555, p 1555 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	pemphigus desmoglein rituximab immunodermatology COVID-19 SARS-CoV-2 Biology (General) QH301-705.5
spellingShingle	pemphigus desmoglein rituximab immunodermatology COVID-19 SARS-CoV-2 Biology (General) QH301-705.5 Branka Marinović Joško Miše Ines Lakoš Jukić Zrinka Bukvić Mokos Pemphigus—The Crux of Clinics, Research, and Treatment during the COVID-19 Pandemic
description	Pemphigus is a rare autoimmune disease characterised by the production of pathogenic autoantibodies in response to different desmosome proteins. The pathophysiological process leads to the development of blisters and erosions on mucosal and/or skin surfaces. The classical clinical variants of pemphigus are pemphigus vulgaris and pemphigus foliaceus. A diagnostic delay is very common in pemphigus, especially among patients with mucosal involvement. However, in recent years we have witnessed considerably fewer patients with extensive mucocutaneous manifestations, since patients with oral lesions are referred to dermatologists to start the treatment much sooner than they had been previously. Among non-classical variants of pemphigus, unusual cases with discrepancies between autoantibody profiles and clinics challenge the “desmoglein compensation theory”. The identification of several other autoantigens that perform a role in the pathogenesis of different variants of pemphigus will progress immunodermatology towards an approach that will determine personalized pemphigus subtypes for each patient. Comorbidities among patients are primarily associated with the prolonged use of corticosteroids and other immunosuppressive agents. The SARS-CoV-2 pandemic raised concerns regarding the immunosuppressive effects of treatment and the risk of a more complicated COVID-19 infection, as well as on the ability to develop an adequate vaccine response.
format	article
author	Branka Marinović Joško Miše Ines Lakoš Jukić Zrinka Bukvić Mokos
author_facet	Branka Marinović Joško Miše Ines Lakoš Jukić Zrinka Bukvić Mokos
author_sort	Branka Marinović
title	Pemphigus—The Crux of Clinics, Research, and Treatment during the COVID-19 Pandemic
title_short	Pemphigus—The Crux of Clinics, Research, and Treatment during the COVID-19 Pandemic
title_full	Pemphigus—The Crux of Clinics, Research, and Treatment during the COVID-19 Pandemic
title_fullStr	Pemphigus—The Crux of Clinics, Research, and Treatment during the COVID-19 Pandemic
title_full_unstemmed	Pemphigus—The Crux of Clinics, Research, and Treatment during the COVID-19 Pandemic
title_sort	pemphigus—the crux of clinics, research, and treatment during the covid-19 pandemic
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/405b8992aae6401696d41ee5350fae14
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Pemphigus—The Crux of Clinics, Research, and Treatment during the COVID-19 Pandemic

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