Aggregation affects optical properties and photothermal heating of gold nanospheres

Abstract Laser heating of gold nanospheres (GNS) is increasingly prevalent in biomedical applications due to tunable optical properties that determine heating efficiency. Although many geometric parameters (i.e. size, morphology) can affect optical properties of individual GNS and their heating, no...

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Autores principales:	Yiru Wang, Zhe Gao, Zonghu Han, Yilin Liu, Huan Yang, Taner Akkin, Christopher J. Hogan, John C. Bischof
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/405d0579edb64c20891b57f6b94118f3
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spelling	oai:doaj.org-article:405d0579edb64c20891b57f6b94118f32021-12-02T14:01:20ZAggregation affects optical properties and photothermal heating of gold nanospheres10.1038/s41598-020-79393-w2045-2322https://doaj.org/article/405d0579edb64c20891b57f6b94118f32021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79393-whttps://doaj.org/toc/2045-2322Abstract Laser heating of gold nanospheres (GNS) is increasingly prevalent in biomedical applications due to tunable optical properties that determine heating efficiency. Although many geometric parameters (i.e. size, morphology) can affect optical properties of individual GNS and their heating, no specific studies of how GNS aggregation affects heating have been carried out. We posit here that aggregation, which can occur within some biological systems, will significantly impact the optical and therefore heating properties of GNS. To address this, we employed discrete dipole approximation (DDA) simulations, Ultraviolet–Visible spectroscopy (UV–Vis) and laser calorimetry on GNS primary particles with diameters (5, 16, 30 nm) and their aggregates that contain 2 to 30 GNS particles. DDA shows that aggregation can reduce the extinction cross-section on a per particle basis by 17–28%. Experimental measurement by UV–Vis and laser calorimetry on aggregates also show up to a 25% reduction in extinction coefficient and significantly lower heating (~ 10%) compared to dispersed GNS. In addition, comparison of select aggregates shows even larger extinction cross section drops in sparse vs. dense aggregates. This work shows that GNS aggregation can change optical properties and reduce heating and provides a new framework for exploring this effect during laser heating of nanomaterial solutions.Yiru WangZhe GaoZonghu HanYilin LiuHuan YangTaner AkkinChristopher J. HoganJohn C. BischofNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yiru Wang Zhe Gao Zonghu Han Yilin Liu Huan Yang Taner Akkin Christopher J. Hogan John C. Bischof Aggregation affects optical properties and photothermal heating of gold nanospheres
description	Abstract Laser heating of gold nanospheres (GNS) is increasingly prevalent in biomedical applications due to tunable optical properties that determine heating efficiency. Although many geometric parameters (i.e. size, morphology) can affect optical properties of individual GNS and their heating, no specific studies of how GNS aggregation affects heating have been carried out. We posit here that aggregation, which can occur within some biological systems, will significantly impact the optical and therefore heating properties of GNS. To address this, we employed discrete dipole approximation (DDA) simulations, Ultraviolet–Visible spectroscopy (UV–Vis) and laser calorimetry on GNS primary particles with diameters (5, 16, 30 nm) and their aggregates that contain 2 to 30 GNS particles. DDA shows that aggregation can reduce the extinction cross-section on a per particle basis by 17–28%. Experimental measurement by UV–Vis and laser calorimetry on aggregates also show up to a 25% reduction in extinction coefficient and significantly lower heating (~ 10%) compared to dispersed GNS. In addition, comparison of select aggregates shows even larger extinction cross section drops in sparse vs. dense aggregates. This work shows that GNS aggregation can change optical properties and reduce heating and provides a new framework for exploring this effect during laser heating of nanomaterial solutions.
format	article
author	Yiru Wang Zhe Gao Zonghu Han Yilin Liu Huan Yang Taner Akkin Christopher J. Hogan John C. Bischof
author_facet	Yiru Wang Zhe Gao Zonghu Han Yilin Liu Huan Yang Taner Akkin Christopher J. Hogan John C. Bischof
author_sort	Yiru Wang
title	Aggregation affects optical properties and photothermal heating of gold nanospheres
title_short	Aggregation affects optical properties and photothermal heating of gold nanospheres
title_full	Aggregation affects optical properties and photothermal heating of gold nanospheres
title_fullStr	Aggregation affects optical properties and photothermal heating of gold nanospheres
title_full_unstemmed	Aggregation affects optical properties and photothermal heating of gold nanospheres
title_sort	aggregation affects optical properties and photothermal heating of gold nanospheres
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/405d0579edb64c20891b57f6b94118f3
work_keys_str_mv	AT yiruwang aggregationaffectsopticalpropertiesandphotothermalheatingofgoldnanospheres AT zhegao aggregationaffectsopticalpropertiesandphotothermalheatingofgoldnanospheres AT zonghuhan aggregationaffectsopticalpropertiesandphotothermalheatingofgoldnanospheres AT yilinliu aggregationaffectsopticalpropertiesandphotothermalheatingofgoldnanospheres AT huanyang aggregationaffectsopticalpropertiesandphotothermalheatingofgoldnanospheres AT tanerakkin aggregationaffectsopticalpropertiesandphotothermalheatingofgoldnanospheres AT christopherjhogan aggregationaffectsopticalpropertiesandphotothermalheatingofgoldnanospheres AT johncbischof aggregationaffectsopticalpropertiesandphotothermalheatingofgoldnanospheres
_version_	1718392194207842304

Aggregation affects optical properties and photothermal heating of gold nanospheres

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