The peroxisomal AAA-ATPase Pex1/Pex6 unfolds substrates by processive threading

Pex1 and Pex6 form a heterohexameric Type-2 AAA-ATPase motor whose function in peroxisomal matrix-protein import is still debated. Here, the authors combine structural, biochemical, and cell-biological approaches to show that Pex1/Pex6 is a protein unfoldase, which supports a role in mechanical unfo...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Brooke M. Gardner, Dominic T. Castanzo, Saikat Chowdhury, Goran Stjepanovic, Matthew S. Stefely, James H. Hurley, Gabriel C. Lander, Andreas Martin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4061a2c4972642c8b618677d741846cd
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4061a2c4972642c8b618677d741846cd
record_format	dspace
spelling	oai:doaj.org-article:4061a2c4972642c8b618677d741846cd2021-12-02T17:32:44ZThe peroxisomal AAA-ATPase Pex1/Pex6 unfolds substrates by processive threading10.1038/s41467-017-02474-42041-1723https://doaj.org/article/4061a2c4972642c8b618677d741846cd2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02474-4https://doaj.org/toc/2041-1723Pex1 and Pex6 form a heterohexameric Type-2 AAA-ATPase motor whose function in peroxisomal matrix-protein import is still debated. Here, the authors combine structural, biochemical, and cell-biological approaches to show that Pex1/Pex6 is a protein unfoldase, which supports a role in mechanical unfolding of peroxin proteins.Brooke M. GardnerDominic T. CastanzoSaikat ChowdhuryGoran StjepanovicMatthew S. StefelyJames H. HurleyGabriel C. LanderAndreas MartinNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Brooke M. Gardner Dominic T. Castanzo Saikat Chowdhury Goran Stjepanovic Matthew S. Stefely James H. Hurley Gabriel C. Lander Andreas Martin The peroxisomal AAA-ATPase Pex1/Pex6 unfolds substrates by processive threading
description	Pex1 and Pex6 form a heterohexameric Type-2 AAA-ATPase motor whose function in peroxisomal matrix-protein import is still debated. Here, the authors combine structural, biochemical, and cell-biological approaches to show that Pex1/Pex6 is a protein unfoldase, which supports a role in mechanical unfolding of peroxin proteins.
format	article
author	Brooke M. Gardner Dominic T. Castanzo Saikat Chowdhury Goran Stjepanovic Matthew S. Stefely James H. Hurley Gabriel C. Lander Andreas Martin
author_facet	Brooke M. Gardner Dominic T. Castanzo Saikat Chowdhury Goran Stjepanovic Matthew S. Stefely James H. Hurley Gabriel C. Lander Andreas Martin
author_sort	Brooke M. Gardner
title	The peroxisomal AAA-ATPase Pex1/Pex6 unfolds substrates by processive threading
title_short	The peroxisomal AAA-ATPase Pex1/Pex6 unfolds substrates by processive threading
title_full	The peroxisomal AAA-ATPase Pex1/Pex6 unfolds substrates by processive threading
title_fullStr	The peroxisomal AAA-ATPase Pex1/Pex6 unfolds substrates by processive threading
title_full_unstemmed	The peroxisomal AAA-ATPase Pex1/Pex6 unfolds substrates by processive threading
title_sort	peroxisomal aaa-atpase pex1/pex6 unfolds substrates by processive threading
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/4061a2c4972642c8b618677d741846cd
work_keys_str_mv	AT brookemgardner theperoxisomalaaaatpasepex1pex6unfoldssubstratesbyprocessivethreading AT dominictcastanzo theperoxisomalaaaatpasepex1pex6unfoldssubstratesbyprocessivethreading AT saikatchowdhury theperoxisomalaaaatpasepex1pex6unfoldssubstratesbyprocessivethreading AT goranstjepanovic theperoxisomalaaaatpasepex1pex6unfoldssubstratesbyprocessivethreading AT matthewsstefely theperoxisomalaaaatpasepex1pex6unfoldssubstratesbyprocessivethreading AT jameshhurley theperoxisomalaaaatpasepex1pex6unfoldssubstratesbyprocessivethreading AT gabrielclander theperoxisomalaaaatpasepex1pex6unfoldssubstratesbyprocessivethreading AT andreasmartin theperoxisomalaaaatpasepex1pex6unfoldssubstratesbyprocessivethreading AT brookemgardner peroxisomalaaaatpasepex1pex6unfoldssubstratesbyprocessivethreading AT dominictcastanzo peroxisomalaaaatpasepex1pex6unfoldssubstratesbyprocessivethreading AT saikatchowdhury peroxisomalaaaatpasepex1pex6unfoldssubstratesbyprocessivethreading AT goranstjepanovic peroxisomalaaaatpasepex1pex6unfoldssubstratesbyprocessivethreading AT matthewsstefely peroxisomalaaaatpasepex1pex6unfoldssubstratesbyprocessivethreading AT jameshhurley peroxisomalaaaatpasepex1pex6unfoldssubstratesbyprocessivethreading AT gabrielclander peroxisomalaaaatpasepex1pex6unfoldssubstratesbyprocessivethreading AT andreasmartin peroxisomalaaaatpasepex1pex6unfoldssubstratesbyprocessivethreading
_version_	1718380181459042304

The peroxisomal AAA-ATPase Pex1/Pex6 unfolds substrates by processive threading

Ejemplares similares