Evaluation of the Clinical Effects and Frequency of MEFV Gene Mutation in Patients with Inflammatory Bowel Disease

Background. The clinical and pathological features of inflammatory bowel disease (IBD) and Familial Mediterranean Fever (FMF) are similar. Objective. Here, the frequency of Mediterranean Fever (MEFV) gene mutation and its effect on the outcome of IBD were evaluated. Methods. DNA sequence analysis de...

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Autores principales:	S. Sahin, D. Gulec, S. Günay, C. Cekic
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/4062895858044f28acd25a19aef2c342
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spelling	oai:doaj.org-article:4062895858044f28acd25a19aef2c3422021-11-29T00:56:42ZEvaluation of the Clinical Effects and Frequency of MEFV Gene Mutation in Patients with Inflammatory Bowel Disease1687-630X10.1155/2021/5538150https://doaj.org/article/4062895858044f28acd25a19aef2c3422021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/5538150https://doaj.org/toc/1687-630XBackground. The clinical and pathological features of inflammatory bowel disease (IBD) and Familial Mediterranean Fever (FMF) are similar. Objective. Here, the frequency of Mediterranean Fever (MEFV) gene mutation and its effect on the outcome of IBD were evaluated. Methods. DNA sequence analysis detected the variants on the MEFV gene in patients with IBD. The relationship between mutations and the need for steroids, immunomodulators, biologics, and surgery was assessed. Results. We evaluated 100 patients with IBD (55 with ulcerative colitis (UC) and 45 with Crohn’s disease (CD)) and 60 healthy individuals as controls. The frequency of MEFV gene mutation was 26.7% (n=12) and 14.5% (n=8) for UC and CD, respectively. No relationship was found between MEFV gene mutation and the need for steroids, immunomodulators, and biologics (p=0.446;p=0.708;p>0.999, resp.); however, in UC, the need for surgery in those with mutation (p=0.018) and E148Q mutation alone was significant (p=0.037). Conclusion. The rate of MEFV gene mutations was high in patients with UC who required surgery. These patients have frequent and severe attacks, indicating that the mutations are related to disease severity. MEFV mutation as a modifier factor of IBD should be considered.S. SahinD. GulecS. GünayC. CekicHindawi LimitedarticleDiseases of the digestive system. GastroenterologyRC799-869ENGastroenterology Research and Practice, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	Diseases of the digestive system. Gastroenterology RC799-869 S. Sahin D. Gulec S. Günay C. Cekic Evaluation of the Clinical Effects and Frequency of MEFV Gene Mutation in Patients with Inflammatory Bowel Disease
description	Background. The clinical and pathological features of inflammatory bowel disease (IBD) and Familial Mediterranean Fever (FMF) are similar. Objective. Here, the frequency of Mediterranean Fever (MEFV) gene mutation and its effect on the outcome of IBD were evaluated. Methods. DNA sequence analysis detected the variants on the MEFV gene in patients with IBD. The relationship between mutations and the need for steroids, immunomodulators, biologics, and surgery was assessed. Results. We evaluated 100 patients with IBD (55 with ulcerative colitis (UC) and 45 with Crohn’s disease (CD)) and 60 healthy individuals as controls. The frequency of MEFV gene mutation was 26.7% (n=12) and 14.5% (n=8) for UC and CD, respectively. No relationship was found between MEFV gene mutation and the need for steroids, immunomodulators, and biologics (p=0.446;p=0.708;p>0.999, resp.); however, in UC, the need for surgery in those with mutation (p=0.018) and E148Q mutation alone was significant (p=0.037). Conclusion. The rate of MEFV gene mutations was high in patients with UC who required surgery. These patients have frequent and severe attacks, indicating that the mutations are related to disease severity. MEFV mutation as a modifier factor of IBD should be considered.
format	article
author	S. Sahin D. Gulec S. Günay C. Cekic
author_facet	S. Sahin D. Gulec S. Günay C. Cekic
author_sort	S. Sahin
title	Evaluation of the Clinical Effects and Frequency of MEFV Gene Mutation in Patients with Inflammatory Bowel Disease
title_short	Evaluation of the Clinical Effects and Frequency of MEFV Gene Mutation in Patients with Inflammatory Bowel Disease
title_full	Evaluation of the Clinical Effects and Frequency of MEFV Gene Mutation in Patients with Inflammatory Bowel Disease
title_fullStr	Evaluation of the Clinical Effects and Frequency of MEFV Gene Mutation in Patients with Inflammatory Bowel Disease
title_full_unstemmed	Evaluation of the Clinical Effects and Frequency of MEFV Gene Mutation in Patients with Inflammatory Bowel Disease
title_sort	evaluation of the clinical effects and frequency of mefv gene mutation in patients with inflammatory bowel disease
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/4062895858044f28acd25a19aef2c342
work_keys_str_mv	AT ssahin evaluationoftheclinicaleffectsandfrequencyofmefvgenemutationinpatientswithinflammatoryboweldisease AT dgulec evaluationoftheclinicaleffectsandfrequencyofmefvgenemutationinpatientswithinflammatoryboweldisease AT sgunay evaluationoftheclinicaleffectsandfrequencyofmefvgenemutationinpatientswithinflammatoryboweldisease AT ccekic evaluationoftheclinicaleffectsandfrequencyofmefvgenemutationinpatientswithinflammatoryboweldisease
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Evaluation of the Clinical Effects and Frequency of MEFV Gene Mutation in Patients with Inflammatory Bowel Disease

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