A subset of lung cancer cases shows robust signs of homologous recombination deficiency associated genomic mutational signatures

Abstract PARP inhibitors are approved for the treatment of solid tumor types that frequently harbor alterations in the key homologous recombination (HR) genes, BRCA1/2. Other tumor types, such as lung cancer, may also be HR deficient, but the frequency of such cases is less well characterized. Speci...

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Autores principales: Miklos Diossy, Zsofia Sztupinszki, Judit Borcsok, Marcin Krzystanek, Viktoria Tisza, Sandor Spisak, Orsolya Rusz, Jozsef Timar, István Csabai, Janos Fillinger, Judit Moldvay, Anders Gorm Pedersen, David Szuts, Zoltan Szallasi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/406462c44b26424ba7040c4796c0ef2d
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