Osteoradionecrosis of the Jaws Due to Teeth Extractions during and after Radiotherapy: A Systematic Review

Teeth extractions before or after radiotherapy (RT) could be procedures at high risk for osteoradionecrosis (ORN) onset. This systematic review was performed to investigate the ORN incidence following teeth extractions during and after RT for head and neck (H&N) cancer and to evaluate any other...

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Autores principales:	Carlo Lajolo, Cosimo Rupe, Gioele Gioco, Giuseppe Troiano, Romeo Patini, Massimo Petruzzi, Francesco Micciche’, Michele Giuliani
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	osteoradionecrosis jaw head and neck cancer radiotherapy tooth extraction Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/40649ecef8b84ea7910fa50673011325
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spelling	oai:doaj.org-article:40649ecef8b84ea7910fa506730113252021-11-25T17:04:09ZOsteoradionecrosis of the Jaws Due to Teeth Extractions during and after Radiotherapy: A Systematic Review10.3390/cancers132257982072-6694https://doaj.org/article/40649ecef8b84ea7910fa506730113252021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5798https://doaj.org/toc/2072-6694Teeth extractions before or after radiotherapy (RT) could be procedures at high risk for osteoradionecrosis (ORN) onset. This systematic review was performed to investigate the ORN incidence following teeth extractions during and after RT for head and neck (H&N) cancer and to evaluate any other possible risk factor. Methods: This systematic review was conducted according to PRISMA protocol, and the PROSPERO registration number was CRD42018079986. An electronic search was performed on the following search engines: PubMed, Scopus, and Web of Science. A cumulative meta-analysis was performed. Results: Two thousand two hundred and eighty-one records were screened, and nine were finally included. This systematic review revealed an ORN incidence of 5.8% (41 patients out of 462, 95% CI = 2.3–9.4); 3 ORN developed in the maxilla. No other clinical risk factors were detected. Conclusion: Post-RT teeth extractions represent a major risk factor for ORN development, especially in the mandible, with a diminishing trend in the last years. Further research on other possible risk factors might improve this evidence.Carlo LajoloCosimo RupeGioele GiocoGiuseppe TroianoRomeo PatiniMassimo PetruzziFrancesco Micciche’Michele GiulianiMDPI AGarticleosteoradionecrosisjawhead and neck cancerradiotherapytooth extractionNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5798, p 5798 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	osteoradionecrosis jaw head and neck cancer radiotherapy tooth extraction Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	osteoradionecrosis jaw head and neck cancer radiotherapy tooth extraction Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Carlo Lajolo Cosimo Rupe Gioele Gioco Giuseppe Troiano Romeo Patini Massimo Petruzzi Francesco Micciche’ Michele Giuliani Osteoradionecrosis of the Jaws Due to Teeth Extractions during and after Radiotherapy: A Systematic Review
description	Teeth extractions before or after radiotherapy (RT) could be procedures at high risk for osteoradionecrosis (ORN) onset. This systematic review was performed to investigate the ORN incidence following teeth extractions during and after RT for head and neck (H&N) cancer and to evaluate any other possible risk factor. Methods: This systematic review was conducted according to PRISMA protocol, and the PROSPERO registration number was CRD42018079986. An electronic search was performed on the following search engines: PubMed, Scopus, and Web of Science. A cumulative meta-analysis was performed. Results: Two thousand two hundred and eighty-one records were screened, and nine were finally included. This systematic review revealed an ORN incidence of 5.8% (41 patients out of 462, 95% CI = 2.3–9.4); 3 ORN developed in the maxilla. No other clinical risk factors were detected. Conclusion: Post-RT teeth extractions represent a major risk factor for ORN development, especially in the mandible, with a diminishing trend in the last years. Further research on other possible risk factors might improve this evidence.
format	article
author	Carlo Lajolo Cosimo Rupe Gioele Gioco Giuseppe Troiano Romeo Patini Massimo Petruzzi Francesco Micciche’ Michele Giuliani
author_facet	Carlo Lajolo Cosimo Rupe Gioele Gioco Giuseppe Troiano Romeo Patini Massimo Petruzzi Francesco Micciche’ Michele Giuliani
author_sort	Carlo Lajolo
title	Osteoradionecrosis of the Jaws Due to Teeth Extractions during and after Radiotherapy: A Systematic Review
title_short	Osteoradionecrosis of the Jaws Due to Teeth Extractions during and after Radiotherapy: A Systematic Review
title_full	Osteoradionecrosis of the Jaws Due to Teeth Extractions during and after Radiotherapy: A Systematic Review
title_fullStr	Osteoradionecrosis of the Jaws Due to Teeth Extractions during and after Radiotherapy: A Systematic Review
title_full_unstemmed	Osteoradionecrosis of the Jaws Due to Teeth Extractions during and after Radiotherapy: A Systematic Review
title_sort	osteoradionecrosis of the jaws due to teeth extractions during and after radiotherapy: a systematic review
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/40649ecef8b84ea7910fa50673011325
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Osteoradionecrosis of the Jaws Due to Teeth Extractions during and after Radiotherapy: A Systematic Review

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