Effects of Topical Tomato (Lycopersicon Lycopersicum L) Extract on Malondyaldehyde Level and the Number of Melanin in Skin Caused by Ultraviolet-B Radiation

INTRODUCTION: UVB radiation on skin may increase reactive oxygen species (ROS) level and cause hyperpigmentation. Polyphenol, an antioxidant contained in tomato, is able to quench ROS and inhibit tyrosinase activity. OBJECTIVE: This study aims to evaluate the effect of topical tomato lotion on Malo...

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Autores principales:	Andreas Yudi Prasetyo Djajadihardja, Taufiqurrachman Nasihun, Atina Hussaana
Formato:	article
Lenguaje:	EN
Publicado:	Universitas Sultan Agung Semarang 2019
Materias:	uvb, tomato extract, mda, melanin Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/406f688821464fc2936ccda8cf314de8
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spelling	oai:doaj.org-article:406f688821464fc2936ccda8cf314de82021-11-25T13:16:18ZEffects of Topical Tomato (Lycopersicon Lycopersicum L) Extract on Malondyaldehyde Level and the Number of Melanin in Skin Caused by Ultraviolet-B Radiation2085-15452339-093Xhttps://doaj.org/article/406f688821464fc2936ccda8cf314de82019-07-01T00:00:00Zhttp://jurnal.unissula.ac.id/index.php/sainsmedika/article/view/2284https://doaj.org/toc/2085-1545https://doaj.org/toc/2339-093XINTRODUCTION: UVB radiation on skin may increase reactive oxygen species (ROS) level and cause hyperpigmentation. Polyphenol, an antioxidant contained in tomato, is able to quench ROS and inhibit tyrosinase activity. OBJECTIVE: This study aims to evaluate the effect of topical tomato lotion on Malondyaldehide (MDA) level and the amount of melanin in skin following UVB radiation. METHODS: In this experimental study, 28 female Balb/c mice are randomly divided into 4 groups: control group (C-G) are given with base lotion, and Lycopersicum groups 0.14 (L-014), 0.7 (L-07) and 1.4 (L-14) are given with tomato lotion of concentration of 0.14%, 0.7% and 1.4% daily, respectively. All of the mice are exposed to UVB at 1MED once every two days for two weeks before lotion application. On day 16, all mice are terminated, and their skin tissues are prepared for MDA level and the amount of melanin assessment. RESULTS: The ANOVA statistical analysis shows a significant difference in the MDA level and the number of melanin of the groups, (p<0.05). The post-hoc LSD analysis shows that the level of MDA in L-14 (1.13) is significantly lower than that in L-07 (2.21), L-014 (2.47), and C-G (5.61), p<0.005. The amount of melanin in L-14 (10.00) is significantly lower than that in L-014 (23.50) and C-G (33.67), p<0.05. The amount of melanin in L-07 (13.00) is not significantly higher than that in L-14, p>0.05. The correlation between MDA level and the amount of melanin shows a strongly positive correlation value (r2) = 0.648 CONCLUSION: Topical administration of tomato extract lotion significantly decreases the MDA level and the number of melanin in the mice’s skin following UVB radiation.Andreas Yudi Prasetyo DjajadihardjaTaufiqurrachman NasihunAtina HussaanaUniversitas Sultan Agung Semarangarticleuvb, tomato extract, mda, melaninMedicine (General)R5-920ENSains Medika, Vol 10, Iss 1, Pp 40-46 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	uvb, tomato extract, mda, melanin Medicine (General) R5-920
spellingShingle	uvb, tomato extract, mda, melanin Medicine (General) R5-920 Andreas Yudi Prasetyo Djajadihardja Taufiqurrachman Nasihun Atina Hussaana Effects of Topical Tomato (Lycopersicon Lycopersicum L) Extract on Malondyaldehyde Level and the Number of Melanin in Skin Caused by Ultraviolet-B Radiation
description	INTRODUCTION: UVB radiation on skin may increase reactive oxygen species (ROS) level and cause hyperpigmentation. Polyphenol, an antioxidant contained in tomato, is able to quench ROS and inhibit tyrosinase activity. OBJECTIVE: This study aims to evaluate the effect of topical tomato lotion on Malondyaldehide (MDA) level and the amount of melanin in skin following UVB radiation. METHODS: In this experimental study, 28 female Balb/c mice are randomly divided into 4 groups: control group (C-G) are given with base lotion, and Lycopersicum groups 0.14 (L-014), 0.7 (L-07) and 1.4 (L-14) are given with tomato lotion of concentration of 0.14%, 0.7% and 1.4% daily, respectively. All of the mice are exposed to UVB at 1MED once every two days for two weeks before lotion application. On day 16, all mice are terminated, and their skin tissues are prepared for MDA level and the amount of melanin assessment. RESULTS: The ANOVA statistical analysis shows a significant difference in the MDA level and the number of melanin of the groups, (p<0.05). The post-hoc LSD analysis shows that the level of MDA in L-14 (1.13) is significantly lower than that in L-07 (2.21), L-014 (2.47), and C-G (5.61), p<0.005. The amount of melanin in L-14 (10.00) is significantly lower than that in L-014 (23.50) and C-G (33.67), p<0.05. The amount of melanin in L-07 (13.00) is not significantly higher than that in L-14, p>0.05. The correlation between MDA level and the amount of melanin shows a strongly positive correlation value (r2) = 0.648 CONCLUSION: Topical administration of tomato extract lotion significantly decreases the MDA level and the number of melanin in the mice’s skin following UVB radiation.
format	article
author	Andreas Yudi Prasetyo Djajadihardja Taufiqurrachman Nasihun Atina Hussaana
author_facet	Andreas Yudi Prasetyo Djajadihardja Taufiqurrachman Nasihun Atina Hussaana
author_sort	Andreas Yudi Prasetyo Djajadihardja
title	Effects of Topical Tomato (Lycopersicon Lycopersicum L) Extract on Malondyaldehyde Level and the Number of Melanin in Skin Caused by Ultraviolet-B Radiation
title_short	Effects of Topical Tomato (Lycopersicon Lycopersicum L) Extract on Malondyaldehyde Level and the Number of Melanin in Skin Caused by Ultraviolet-B Radiation
title_full	Effects of Topical Tomato (Lycopersicon Lycopersicum L) Extract on Malondyaldehyde Level and the Number of Melanin in Skin Caused by Ultraviolet-B Radiation
title_fullStr	Effects of Topical Tomato (Lycopersicon Lycopersicum L) Extract on Malondyaldehyde Level and the Number of Melanin in Skin Caused by Ultraviolet-B Radiation
title_full_unstemmed	Effects of Topical Tomato (Lycopersicon Lycopersicum L) Extract on Malondyaldehyde Level and the Number of Melanin in Skin Caused by Ultraviolet-B Radiation
title_sort	effects of topical tomato (lycopersicon lycopersicum l) extract on malondyaldehyde level and the number of melanin in skin caused by ultraviolet-b radiation
publisher	Universitas Sultan Agung Semarang
publishDate	2019
url	https://doaj.org/article/406f688821464fc2936ccda8cf314de8
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Effects of Topical Tomato (Lycopersicon Lycopersicum L) Extract on Malondyaldehyde Level and the Number of Melanin in Skin Caused by Ultraviolet-B Radiation

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