Super-resolution microscopy reveals ultra-low CD19 expression on myeloma cells that triggers elimination by CD19 CAR-T

CD19 CAR-T cells have achieved some success in treating myeloma patients despite the limited detection of the CD19 antigen. Here, the authors show using dSTORM that 10/14 myeloma samples studied express ultra-low levels of CD19, which are sufficient for engaging CAR-T cells in vitro.

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Autores principales:	Thomas Nerreter, Sebastian Letschert, Ralph Götz, Sören Doose, Sophia Danhof, Hermann Einsele, Markus Sauer, Michael Hudecek
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/406f8042514e434299b754fc01f1e692
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spelling	oai:doaj.org-article:406f8042514e434299b754fc01f1e6922021-12-02T14:38:46ZSuper-resolution microscopy reveals ultra-low CD19 expression on myeloma cells that triggers elimination by CD19 CAR-T10.1038/s41467-019-10948-w2041-1723https://doaj.org/article/406f8042514e434299b754fc01f1e6922019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10948-whttps://doaj.org/toc/2041-1723CD19 CAR-T cells have achieved some success in treating myeloma patients despite the limited detection of the CD19 antigen. Here, the authors show using dSTORM that 10/14 myeloma samples studied express ultra-low levels of CD19, which are sufficient for engaging CAR-T cells in vitro.Thomas NerreterSebastian LetschertRalph GötzSören DooseSophia DanhofHermann EinseleMarkus SauerMichael HudecekNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Thomas Nerreter Sebastian Letschert Ralph Götz Sören Doose Sophia Danhof Hermann Einsele Markus Sauer Michael Hudecek Super-resolution microscopy reveals ultra-low CD19 expression on myeloma cells that triggers elimination by CD19 CAR-T
description	CD19 CAR-T cells have achieved some success in treating myeloma patients despite the limited detection of the CD19 antigen. Here, the authors show using dSTORM that 10/14 myeloma samples studied express ultra-low levels of CD19, which are sufficient for engaging CAR-T cells in vitro.
format	article
author	Thomas Nerreter Sebastian Letschert Ralph Götz Sören Doose Sophia Danhof Hermann Einsele Markus Sauer Michael Hudecek
author_facet	Thomas Nerreter Sebastian Letschert Ralph Götz Sören Doose Sophia Danhof Hermann Einsele Markus Sauer Michael Hudecek
author_sort	Thomas Nerreter
title	Super-resolution microscopy reveals ultra-low CD19 expression on myeloma cells that triggers elimination by CD19 CAR-T
title_short	Super-resolution microscopy reveals ultra-low CD19 expression on myeloma cells that triggers elimination by CD19 CAR-T
title_full	Super-resolution microscopy reveals ultra-low CD19 expression on myeloma cells that triggers elimination by CD19 CAR-T
title_fullStr	Super-resolution microscopy reveals ultra-low CD19 expression on myeloma cells that triggers elimination by CD19 CAR-T
title_full_unstemmed	Super-resolution microscopy reveals ultra-low CD19 expression on myeloma cells that triggers elimination by CD19 CAR-T
title_sort	super-resolution microscopy reveals ultra-low cd19 expression on myeloma cells that triggers elimination by cd19 car-t
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/406f8042514e434299b754fc01f1e692
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Super-resolution microscopy reveals ultra-low CD19 expression on myeloma cells that triggers elimination by CD19 CAR-T

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