Super-resolution microscopy reveals ultra-low CD19 expression on myeloma cells that triggers elimination by CD19 CAR-T
CD19 CAR-T cells have achieved some success in treating myeloma patients despite the limited detection of the CD19 antigen. Here, the authors show using dSTORM that 10/14 myeloma samples studied express ultra-low levels of CD19, which are sufficient for engaging CAR-T cells in vitro.
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Autores principales: | Thomas Nerreter, Sebastian Letschert, Ralph Götz, Sören Doose, Sophia Danhof, Hermann Einsele, Markus Sauer, Michael Hudecek |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2019
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Materias: | |
Acceso en línea: | https://doaj.org/article/406f8042514e434299b754fc01f1e692 |
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