Inhibition of the ATP Synthase Eliminates the Intrinsic Resistance of <italic toggle="yes">Staphylococcus aureus</italic> towards Polymyxins

Inhibition of the ATP Synthase Eliminates the Intrinsic Resistance of <italic toggle="yes">Staphylococcus aureus</italic> towards Polymyxins

ABSTRACT Staphylococcus aureus is intrinsically resistant to polymyxins (polymyxin B and colistin), an important class of cationic antimicrobial peptides used in treatment of Gram-negative bacterial infections. To understand the mechanisms underlying intrinsic polymyxin resistance in S. aureus, we s...

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Autores principales: Martin Vestergaard, Katrine Nøhr-Meldgaard, Martin Saxtorph Bojer, Christina Krogsgård Nielsen, Rikke Louise Meyer, Christoph Slavetinsky, Andreas Peschel, Hanne Ingmer
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2017
Materias:
ATP synthase
Staphylococcus aureus
antimicrobial peptides
atpA
intrinsic resistance
oligomycin A
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/4070bcfecf0543d99c2c514279899795
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