HIV- and AIDS-associated neurocognitive functioning in Zambia – a perspective based on differences between the genders

HIV- and AIDS-associated neurocognitive functioning in Zambia – a perspective based on differences between the genders

Norma Kabuba,1,2 J Anitha Menon,1 Donald R Franklin Jr,3 Robert K Heaton,3 Knut A Hestad2,4,5 1Department of Psychology, The University of Zambia, Lusaka, Zambia; 2Department of Psychology, Norwegian University of Science and Technology, Trondheim, Norway; 3Department of Psychiatry, University of C...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Kabuba N, Menon JA, Franklin Jr DR, Heaton RK, Hestad KA
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2016
Materias:
HIV-1
Neurocognitive functioning
Gender
Zambia
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Acceso en línea:https://doaj.org/article/40713c6284bc4765a7edaaca171197e3
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:40713c6284bc4765a7edaaca171197e3
record_format dspace
spelling oai:doaj.org-article:40713c6284bc4765a7edaaca171197e32021-12-02T04:17:07ZHIV- and AIDS-associated neurocognitive functioning in Zambia – a perspective based on differences between the genders1178-2021https://doaj.org/article/40713c6284bc4765a7edaaca171197e32016-08-01T00:00:00Zhttps://www.dovepress.com/hiv--and-aids-associated-neurocognitive-functioning-in-zambia-ndash-a--peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Norma Kabuba,1,2 J Anitha Menon,1 Donald R Franklin Jr,3 Robert K Heaton,3 Knut A Hestad2,4,5 1Department of Psychology, The University of Zambia, Lusaka, Zambia; 2Department of Psychology, Norwegian University of Science and Technology, Trondheim, Norway; 3Department of Psychiatry, University of California, San Diego, CA, USA; 4Department of Research, Innlandet Hospital Trust, Hamar, Norway; 5Department of Public Health, Hedmark University of Applied Sciences, Elverum, Norway Abstract: Human immunodeficiency virus (HIV) infection and acquired immune deficiency syndrome (AIDS) are frequently associated with neurocognitive impairment (NCI). However, few studies have examined the interrelationship between gender and NCI in the HIV and AIDS population. This cross-sectional study examined the neurocognitive (NC) functioning of HIV-infected male and female adults from urban Zambia. The participants included 266 HIV seropositive (HIV+) adults (males [n=107] and females [n=159]). Participants completed NC assessment by means of a comprehensive test battery using normative data from 324 HIV-seronegative (HIV-) controls. The norms corrected for effects of age, education, and gender in the general population, and the test battery measures domains of attention/working memory (learning and delayed recall), executive function, verbal fluency, processing speed, verbal and visual episodic memory, and fine motor skills. An overall comparison of the HIV+ male and female participants yielded no statistically significant differences. Analysis of covariance results controlling for disease characteristics showed that HIV+ female participants had worse delayed recall scores than males, F(1,117) =9.70, P=0.002, partial ƞ2=0.077. The females also evidenced a trend toward greater impairment on learning efficiency (P=0.015). The findings suggest that there are gender-related differences in NCI after controlling for disease characteristics. It was observed that although the HIV+ females enjoyed better health compared to their HIV+ male counterparts, they still had worse performance on the neuropsychological tests. This implies that HIV may have more NC consequences for Zambian females than males. Keywords: HIV-1, neurocognitive functioning, gender, ZambiaKabuba NMenon JAFranklin Jr DRHeaton RKHestad KADove Medical PressarticleHIV-1Neurocognitive functioningGenderZambiaNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2016, Iss Issue 1, Pp 2021-2028 (2016)
institution DOAJ
collection DOAJ
language EN
topic HIV-1
Neurocognitive functioning
Gender
Zambia
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle HIV-1
Neurocognitive functioning
Gender
Zambia
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Kabuba N
Menon JA
Franklin Jr DR
Heaton RK
Hestad KA
HIV- and AIDS-associated neurocognitive functioning in Zambia – a perspective based on differences between the genders
description Norma Kabuba,1,2 J Anitha Menon,1 Donald R Franklin Jr,3 Robert K Heaton,3 Knut A Hestad2,4,5 1Department of Psychology, The University of Zambia, Lusaka, Zambia; 2Department of Psychology, Norwegian University of Science and Technology, Trondheim, Norway; 3Department of Psychiatry, University of California, San Diego, CA, USA; 4Department of Research, Innlandet Hospital Trust, Hamar, Norway; 5Department of Public Health, Hedmark University of Applied Sciences, Elverum, Norway Abstract: Human immunodeficiency virus (HIV) infection and acquired immune deficiency syndrome (AIDS) are frequently associated with neurocognitive impairment (NCI). However, few studies have examined the interrelationship between gender and NCI in the HIV and AIDS population. This cross-sectional study examined the neurocognitive (NC) functioning of HIV-infected male and female adults from urban Zambia. The participants included 266 HIV seropositive (HIV+) adults (males [n=107] and females [n=159]). Participants completed NC assessment by means of a comprehensive test battery using normative data from 324 HIV-seronegative (HIV-) controls. The norms corrected for effects of age, education, and gender in the general population, and the test battery measures domains of attention/working memory (learning and delayed recall), executive function, verbal fluency, processing speed, verbal and visual episodic memory, and fine motor skills. An overall comparison of the HIV+ male and female participants yielded no statistically significant differences. Analysis of covariance results controlling for disease characteristics showed that HIV+ female participants had worse delayed recall scores than males, F(1,117) =9.70, P=0.002, partial ƞ2=0.077. The females also evidenced a trend toward greater impairment on learning efficiency (P=0.015). The findings suggest that there are gender-related differences in NCI after controlling for disease characteristics. It was observed that although the HIV+ females enjoyed better health compared to their HIV+ male counterparts, they still had worse performance on the neuropsychological tests. This implies that HIV may have more NC consequences for Zambian females than males. Keywords: HIV-1, neurocognitive functioning, gender, Zambia
format article
author Kabuba N
Menon JA
Franklin Jr DR
Heaton RK
Hestad KA
author_facet Kabuba N
Menon JA
Franklin Jr DR
Heaton RK
Hestad KA
author_sort Kabuba N
title HIV- and AIDS-associated neurocognitive functioning in Zambia – a perspective based on differences between the genders
title_short HIV- and AIDS-associated neurocognitive functioning in Zambia – a perspective based on differences between the genders
title_full HIV- and AIDS-associated neurocognitive functioning in Zambia – a perspective based on differences between the genders
title_fullStr HIV- and AIDS-associated neurocognitive functioning in Zambia – a perspective based on differences between the genders
title_full_unstemmed HIV- and AIDS-associated neurocognitive functioning in Zambia – a perspective based on differences between the genders
title_sort hiv- and aids-associated neurocognitive functioning in zambia – a perspective based on differences between the genders
publisher Dove Medical Press
publishDate 2016
url https://doaj.org/article/40713c6284bc4765a7edaaca171197e3
work_keys_str_mv AT kabuban hivandaidsassociatedneurocognitivefunctioninginzambiandashaperspectivebasedondifferencesbetweenthegenders
AT menonja hivandaidsassociatedneurocognitivefunctioninginzambiandashaperspectivebasedondifferencesbetweenthegenders
AT franklinjrdr hivandaidsassociatedneurocognitivefunctioninginzambiandashaperspectivebasedondifferencesbetweenthegenders
AT heatonrk hivandaidsassociatedneurocognitivefunctioninginzambiandashaperspectivebasedondifferencesbetweenthegenders
AT hestadka hivandaidsassociatedneurocognitivefunctioninginzambiandashaperspectivebasedondifferencesbetweenthegenders
_version_ 1718401306102595584

Ejemplares similares