Engineered transfer RNAs for suppression of premature termination codons

Premature termination codon suppression therapy could be used to treat a range of genetic disorders. Here the authors present a high-throughput cell-based assay to identify anticodon engineered tRNAs with high suppression activity.

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Autores principales:	John D. Lueck, Jae Seok Yoon, Alfredo Perales-Puchalt, Adam L. Mackey, Daniel T. Infield, Mark A. Behlke, Marshall R. Pope, David B. Weiner, William R. Skach, Paul B. McCray, Christopher A. Ahern
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/407180d474f9434ca10313d5ef3ae933
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spelling	oai:doaj.org-article:407180d474f9434ca10313d5ef3ae9332021-12-02T14:38:57ZEngineered transfer RNAs for suppression of premature termination codons10.1038/s41467-019-08329-42041-1723https://doaj.org/article/407180d474f9434ca10313d5ef3ae9332019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08329-4https://doaj.org/toc/2041-1723Premature termination codon suppression therapy could be used to treat a range of genetic disorders. Here the authors present a high-throughput cell-based assay to identify anticodon engineered tRNAs with high suppression activity.John D. LueckJae Seok YoonAlfredo Perales-PuchaltAdam L. MackeyDaniel T. InfieldMark A. BehlkeMarshall R. PopeDavid B. WeinerWilliam R. SkachPaul B. McCrayChristopher A. AhernNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q John D. Lueck Jae Seok Yoon Alfredo Perales-Puchalt Adam L. Mackey Daniel T. Infield Mark A. Behlke Marshall R. Pope David B. Weiner William R. Skach Paul B. McCray Christopher A. Ahern Engineered transfer RNAs for suppression of premature termination codons
description	Premature termination codon suppression therapy could be used to treat a range of genetic disorders. Here the authors present a high-throughput cell-based assay to identify anticodon engineered tRNAs with high suppression activity.
format	article
author	John D. Lueck Jae Seok Yoon Alfredo Perales-Puchalt Adam L. Mackey Daniel T. Infield Mark A. Behlke Marshall R. Pope David B. Weiner William R. Skach Paul B. McCray Christopher A. Ahern
author_facet	John D. Lueck Jae Seok Yoon Alfredo Perales-Puchalt Adam L. Mackey Daniel T. Infield Mark A. Behlke Marshall R. Pope David B. Weiner William R. Skach Paul B. McCray Christopher A. Ahern
author_sort	John D. Lueck
title	Engineered transfer RNAs for suppression of premature termination codons
title_short	Engineered transfer RNAs for suppression of premature termination codons
title_full	Engineered transfer RNAs for suppression of premature termination codons
title_fullStr	Engineered transfer RNAs for suppression of premature termination codons
title_full_unstemmed	Engineered transfer RNAs for suppression of premature termination codons
title_sort	engineered transfer rnas for suppression of premature termination codons
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/407180d474f9434ca10313d5ef3ae933
work_keys_str_mv	AT johndlueck engineeredtransferrnasforsuppressionofprematureterminationcodons AT jaeseokyoon engineeredtransferrnasforsuppressionofprematureterminationcodons AT alfredoperalespuchalt engineeredtransferrnasforsuppressionofprematureterminationcodons AT adamlmackey engineeredtransferrnasforsuppressionofprematureterminationcodons AT danieltinfield engineeredtransferrnasforsuppressionofprematureterminationcodons AT markabehlke engineeredtransferrnasforsuppressionofprematureterminationcodons AT marshallrpope engineeredtransferrnasforsuppressionofprematureterminationcodons AT davidbweiner engineeredtransferrnasforsuppressionofprematureterminationcodons AT williamrskach engineeredtransferrnasforsuppressionofprematureterminationcodons AT paulbmccray engineeredtransferrnasforsuppressionofprematureterminationcodons AT christopheraahern engineeredtransferrnasforsuppressionofprematureterminationcodons
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Engineered transfer RNAs for suppression of premature termination codons

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