Association of Interleukin-12A rs568408 with Susceptibility to Asthma in Taiwan

Abstract Asthma is an inflammatory disease and interleukin 12 (IL-12) may play a regulatory role in allergen-induced inflammation. The aim of this study was to investigate the association of polymorphisms in IL-12A/IL-12B with asthma. The asthma group included 198 adult patients and the control grou...

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Autores principales:	Te-Chun Shen, Chia-Wen Tsai, Wen-Shin Chang, Shengyu Wang, Che-Yi Chao, Chieh-Lun Hsiao, Wei-Chun Chen, Te-Chun Hsia, Da-Tian Bau
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4072b9642f674fe490327aa5f7969fa0
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spelling	oai:doaj.org-article:4072b9642f674fe490327aa5f7969fa02021-12-02T12:31:46ZAssociation of Interleukin-12A rs568408 with Susceptibility to Asthma in Taiwan10.1038/s41598-017-03523-02045-2322https://doaj.org/article/4072b9642f674fe490327aa5f7969fa02017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03523-0https://doaj.org/toc/2045-2322Abstract Asthma is an inflammatory disease and interleukin 12 (IL-12) may play a regulatory role in allergen-induced inflammation. The aim of this study was to investigate the association of polymorphisms in IL-12A/IL-12B with asthma. The asthma group included 198 adult patients and the control group included 453 individuals without asthma that were frequency-matched by gender and age. The distribution of genotypic and allelic frequencies of IL-12A rs568408 demonstrated significant differences between case and control groups. Specifically, the percentages of AA genotype of IL-12A rs568408 was significantly higher among asthmatic patients in Taiwan than healthy controls, compared to GG genotype. No significant difference was observed among the IL-12A rs2243115 and IL-12B rs3212227 genotypes between case and control groups. In addition, the A allele at IL-12A rs568408 was associated with more severe symptoms (P = 0.0085) among asthmatic patients. These results suggest that IL-12A rs568408 may contribute to the etiology and symptoms severity of asthma, indicating its usefulness as a predictive and diagnostic biomarker of asthma.Te-Chun ShenChia-Wen TsaiWen-Shin ChangShengyu WangChe-Yi ChaoChieh-Lun HsiaoWei-Chun ChenTe-Chun HsiaDa-Tian BauNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Te-Chun Shen Chia-Wen Tsai Wen-Shin Chang Shengyu Wang Che-Yi Chao Chieh-Lun Hsiao Wei-Chun Chen Te-Chun Hsia Da-Tian Bau Association of Interleukin-12A rs568408 with Susceptibility to Asthma in Taiwan
description	Abstract Asthma is an inflammatory disease and interleukin 12 (IL-12) may play a regulatory role in allergen-induced inflammation. The aim of this study was to investigate the association of polymorphisms in IL-12A/IL-12B with asthma. The asthma group included 198 adult patients and the control group included 453 individuals without asthma that were frequency-matched by gender and age. The distribution of genotypic and allelic frequencies of IL-12A rs568408 demonstrated significant differences between case and control groups. Specifically, the percentages of AA genotype of IL-12A rs568408 was significantly higher among asthmatic patients in Taiwan than healthy controls, compared to GG genotype. No significant difference was observed among the IL-12A rs2243115 and IL-12B rs3212227 genotypes between case and control groups. In addition, the A allele at IL-12A rs568408 was associated with more severe symptoms (P = 0.0085) among asthmatic patients. These results suggest that IL-12A rs568408 may contribute to the etiology and symptoms severity of asthma, indicating its usefulness as a predictive and diagnostic biomarker of asthma.
format	article
author	Te-Chun Shen Chia-Wen Tsai Wen-Shin Chang Shengyu Wang Che-Yi Chao Chieh-Lun Hsiao Wei-Chun Chen Te-Chun Hsia Da-Tian Bau
author_facet	Te-Chun Shen Chia-Wen Tsai Wen-Shin Chang Shengyu Wang Che-Yi Chao Chieh-Lun Hsiao Wei-Chun Chen Te-Chun Hsia Da-Tian Bau
author_sort	Te-Chun Shen
title	Association of Interleukin-12A rs568408 with Susceptibility to Asthma in Taiwan
title_short	Association of Interleukin-12A rs568408 with Susceptibility to Asthma in Taiwan
title_full	Association of Interleukin-12A rs568408 with Susceptibility to Asthma in Taiwan
title_fullStr	Association of Interleukin-12A rs568408 with Susceptibility to Asthma in Taiwan
title_full_unstemmed	Association of Interleukin-12A rs568408 with Susceptibility to Asthma in Taiwan
title_sort	association of interleukin-12a rs568408 with susceptibility to asthma in taiwan
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4072b9642f674fe490327aa5f7969fa0
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Association of Interleukin-12A rs568408 with Susceptibility to Asthma in Taiwan

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