Sensory TRP channels contribute differentially to skin inflammation and persistent itch

Allergic contact dermatitis is associated both with persistent itch and inflammation, but it is not known if these are mediated by shared signaling pathways. The authors show that persistent itch requires both TRPA1 and TRPV1, while TRPV1 has a protective role against skin inflammation in mice.

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Autores principales:	Jing Feng, Pu Yang, Madison R. Mack, Dariia Dryn, Jialie Luo, Xuan Gong, Shenbin Liu, Landon K. Oetjen, Alexander V. Zholos, Zhinan Mei, Shijin Yin, Brian S. Kim, Hongzhen Hu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4078181e402a4584941d633042f9add0
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spelling	oai:doaj.org-article:4078181e402a4584941d633042f9add02021-12-02T17:06:05ZSensory TRP channels contribute differentially to skin inflammation and persistent itch10.1038/s41467-017-01056-82041-1723https://doaj.org/article/4078181e402a4584941d633042f9add02017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01056-8https://doaj.org/toc/2041-1723Allergic contact dermatitis is associated both with persistent itch and inflammation, but it is not known if these are mediated by shared signaling pathways. The authors show that persistent itch requires both TRPA1 and TRPV1, while TRPV1 has a protective role against skin inflammation in mice.Jing FengPu YangMadison R. MackDariia DrynJialie LuoXuan GongShenbin LiuLandon K. OetjenAlexander V. ZholosZhinan MeiShijin YinBrian S. KimHongzhen HuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jing Feng Pu Yang Madison R. Mack Dariia Dryn Jialie Luo Xuan Gong Shenbin Liu Landon K. Oetjen Alexander V. Zholos Zhinan Mei Shijin Yin Brian S. Kim Hongzhen Hu Sensory TRP channels contribute differentially to skin inflammation and persistent itch
description	Allergic contact dermatitis is associated both with persistent itch and inflammation, but it is not known if these are mediated by shared signaling pathways. The authors show that persistent itch requires both TRPA1 and TRPV1, while TRPV1 has a protective role against skin inflammation in mice.
format	article
author	Jing Feng Pu Yang Madison R. Mack Dariia Dryn Jialie Luo Xuan Gong Shenbin Liu Landon K. Oetjen Alexander V. Zholos Zhinan Mei Shijin Yin Brian S. Kim Hongzhen Hu
author_facet	Jing Feng Pu Yang Madison R. Mack Dariia Dryn Jialie Luo Xuan Gong Shenbin Liu Landon K. Oetjen Alexander V. Zholos Zhinan Mei Shijin Yin Brian S. Kim Hongzhen Hu
author_sort	Jing Feng
title	Sensory TRP channels contribute differentially to skin inflammation and persistent itch
title_short	Sensory TRP channels contribute differentially to skin inflammation and persistent itch
title_full	Sensory TRP channels contribute differentially to skin inflammation and persistent itch
title_fullStr	Sensory TRP channels contribute differentially to skin inflammation and persistent itch
title_full_unstemmed	Sensory TRP channels contribute differentially to skin inflammation and persistent itch
title_sort	sensory trp channels contribute differentially to skin inflammation and persistent itch
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4078181e402a4584941d633042f9add0
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Sensory TRP channels contribute differentially to skin inflammation and persistent itch

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