Enhancer accessibility and CTCF occupancy underlie asymmetric TAD architecture and cell type specific genome topology

Eukaryotic genomes fold into topologically associated domains (TAD). Here the authors characterise a TAD regulatory architecture underlying lineage-specific gene regulation, finding that stripe TADs are associated with poised and active chromatin landscapes and linked to the cells functional state.

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Autores principales:	Christopher Barrington, Dimitra Georgopoulou, Dubravka Pezic, Wazeer Varsally, Javier Herrero, Suzana Hadjur
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4079930968d542f19a66096e3016823b
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spelling	oai:doaj.org-article:4079930968d542f19a66096e3016823b2021-12-02T15:35:38ZEnhancer accessibility and CTCF occupancy underlie asymmetric TAD architecture and cell type specific genome topology10.1038/s41467-019-10725-92041-1723https://doaj.org/article/4079930968d542f19a66096e3016823b2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10725-9https://doaj.org/toc/2041-1723Eukaryotic genomes fold into topologically associated domains (TAD). Here the authors characterise a TAD regulatory architecture underlying lineage-specific gene regulation, finding that stripe TADs are associated with poised and active chromatin landscapes and linked to the cells functional state.Christopher BarringtonDimitra GeorgopoulouDubravka PezicWazeer VarsallyJavier HerreroSuzana HadjurNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Christopher Barrington Dimitra Georgopoulou Dubravka Pezic Wazeer Varsally Javier Herrero Suzana Hadjur Enhancer accessibility and CTCF occupancy underlie asymmetric TAD architecture and cell type specific genome topology
description	Eukaryotic genomes fold into topologically associated domains (TAD). Here the authors characterise a TAD regulatory architecture underlying lineage-specific gene regulation, finding that stripe TADs are associated with poised and active chromatin landscapes and linked to the cells functional state.
format	article
author	Christopher Barrington Dimitra Georgopoulou Dubravka Pezic Wazeer Varsally Javier Herrero Suzana Hadjur
author_facet	Christopher Barrington Dimitra Georgopoulou Dubravka Pezic Wazeer Varsally Javier Herrero Suzana Hadjur
author_sort	Christopher Barrington
title	Enhancer accessibility and CTCF occupancy underlie asymmetric TAD architecture and cell type specific genome topology
title_short	Enhancer accessibility and CTCF occupancy underlie asymmetric TAD architecture and cell type specific genome topology
title_full	Enhancer accessibility and CTCF occupancy underlie asymmetric TAD architecture and cell type specific genome topology
title_fullStr	Enhancer accessibility and CTCF occupancy underlie asymmetric TAD architecture and cell type specific genome topology
title_full_unstemmed	Enhancer accessibility and CTCF occupancy underlie asymmetric TAD architecture and cell type specific genome topology
title_sort	enhancer accessibility and ctcf occupancy underlie asymmetric tad architecture and cell type specific genome topology
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/4079930968d542f19a66096e3016823b
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Enhancer accessibility and CTCF occupancy underlie asymmetric TAD architecture and cell type specific genome topology

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