Impulsivity, gender, and the platelet serotonin transporter in healthy subjects

Donatella Marazziti, Stefano Baroni, Irene Masala, Francesca Golia, Giorgio Consoli, Gabriele Massimetti, Michela Picchetti, Mario Catena Dell&rsquo;Osso, Gino Giannaccini, Laura Betti, Antonio Lucacchini, Antonio CiapparelliDipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecno...

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Autores principales:	Donatella Marazziti, Stefano Baroni, Irene Masala, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2009
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/4080b146c5d74c43aed3234c47f9aab6
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spelling	oai:doaj.org-article:4080b146c5d74c43aed3234c47f9aab62021-12-02T00:51:03ZImpulsivity, gender, and the platelet serotonin transporter in healthy subjects1176-63281178-2021https://doaj.org/article/4080b146c5d74c43aed3234c47f9aab62009-12-01T00:00:00Zhttp://www.dovepress.com/impulsivity-gender-and-the-platelet-serotonin-transporter-in-healthy-s-a3851https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Donatella Marazziti, Stefano Baroni, Irene Masala, Francesca Golia, Giorgio Consoli, Gabriele Massimetti, Michela Picchetti, Mario Catena Dell&rsquo;Osso, Gino Giannaccini, Laura Betti, Antonio Lucacchini, Antonio CiapparelliDipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Pisa, ItalyAbstract: The present study explored the possible relationships between impulsivity, gender, and a peripheral serotonergic marker, the platelet serotonin (5-HT) transporter (SERT), in a group of 32 healthy subjects. The impulsivity was measured by means of the Barratt Impulsivity Scale, version 11 (BIS-11), a widely used self-report questionnaire, and the platelet SERT was evaluated by means of the specific binding of 3H-paroxetine (3H-Par) to platelet membranes, according to standardized protocols. The results showed that women had a higher BIS-11 total score than men, and also higher scores of two factors of the same scale: the motor impulsivity and the cognitive complexity. The analysis of the correlations revealed that the density of the SERT proteins, as measured by the maximum binding capacity (Bmax) of 3H-Par, was significantly and positively related to the cognitive complexity factor, but only in men. Men showed also a significant and negative correlation with the dissociation constant, Kd, of (3H-Par) binding, and the motor impulsivity factor. These findings suggest that women are generally more impulsive than men, but that the 5-HT system is more involved in the impulsivity of men than in that of women.Keywords: impulsivity, gender, serotonin transporter, Barratt Impulsivity Scale, platelets, 3H-paroxetine Donatella MarazzitiStefano BaroniIrene Masalaet alDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2010, Iss Issue 1, Pp 9-15 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Donatella Marazziti Stefano Baroni Irene Masala et al Impulsivity, gender, and the platelet serotonin transporter in healthy subjects
description	Donatella Marazziti, Stefano Baroni, Irene Masala, Francesca Golia, Giorgio Consoli, Gabriele Massimetti, Michela Picchetti, Mario Catena Dell&rsquo;Osso, Gino Giannaccini, Laura Betti, Antonio Lucacchini, Antonio CiapparelliDipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Pisa, ItalyAbstract: The present study explored the possible relationships between impulsivity, gender, and a peripheral serotonergic marker, the platelet serotonin (5-HT) transporter (SERT), in a group of 32 healthy subjects. The impulsivity was measured by means of the Barratt Impulsivity Scale, version 11 (BIS-11), a widely used self-report questionnaire, and the platelet SERT was evaluated by means of the specific binding of 3H-paroxetine (3H-Par) to platelet membranes, according to standardized protocols. The results showed that women had a higher BIS-11 total score than men, and also higher scores of two factors of the same scale: the motor impulsivity and the cognitive complexity. The analysis of the correlations revealed that the density of the SERT proteins, as measured by the maximum binding capacity (Bmax) of 3H-Par, was significantly and positively related to the cognitive complexity factor, but only in men. Men showed also a significant and negative correlation with the dissociation constant, Kd, of (3H-Par) binding, and the motor impulsivity factor. These findings suggest that women are generally more impulsive than men, but that the 5-HT system is more involved in the impulsivity of men than in that of women.Keywords: impulsivity, gender, serotonin transporter, Barratt Impulsivity Scale, platelets, 3H-paroxetine
format	article
author	Donatella Marazziti Stefano Baroni Irene Masala et al
author_facet	Donatella Marazziti Stefano Baroni Irene Masala et al
author_sort	Donatella Marazziti
title	Impulsivity, gender, and the platelet serotonin transporter in healthy subjects
title_short	Impulsivity, gender, and the platelet serotonin transporter in healthy subjects
title_full	Impulsivity, gender, and the platelet serotonin transporter in healthy subjects
title_fullStr	Impulsivity, gender, and the platelet serotonin transporter in healthy subjects
title_full_unstemmed	Impulsivity, gender, and the platelet serotonin transporter in healthy subjects
title_sort	impulsivity, gender, and the platelet serotonin transporter in healthy subjects
publisher	Dove Medical Press
publishDate	2009
url	https://doaj.org/article/4080b146c5d74c43aed3234c47f9aab6
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Impulsivity, gender, and the platelet serotonin transporter in healthy subjects

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