Unhealthy lifestyles and brain condition: Examining the relations of BMI, living alone, alcohol intake, short sleep, smoking, and lack of exercise with gray matter volume.

Unhealthy lifestyles are damaging to the brain. Previous studies have indicated that body mass index (BMI), alcohol intake, short sleep, smoking, and lack of exercise are negatively associated with gray matter volume (GMV). Living alone has also been found to be related to GMV through lowered subjec...

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Autores principales:	Keisuke Kokubun, Juan Cesar D Pineda, Yoshinori Yamakawa
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/40829b4ac1fa43018432d407e19b61a5
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spelling	oai:doaj.org-article:40829b4ac1fa43018432d407e19b61a52021-12-02T20:08:49ZUnhealthy lifestyles and brain condition: Examining the relations of BMI, living alone, alcohol intake, short sleep, smoking, and lack of exercise with gray matter volume.1932-620310.1371/journal.pone.0255285https://doaj.org/article/40829b4ac1fa43018432d407e19b61a52021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255285https://doaj.org/toc/1932-6203Unhealthy lifestyles are damaging to the brain. Previous studies have indicated that body mass index (BMI), alcohol intake, short sleep, smoking, and lack of exercise are negatively associated with gray matter volume (GMV). Living alone has also been found to be related to GMV through lowered subjective happiness. However, to our knowledge, no GMV study has dealt with these unhealthy lifestyles simultaneously. By our analyses based on 142 healthy Japanese participants, BMI, alcohol intake, living alone, and short sleep were negatively associated with the gray-matter brain healthcare quotient (GM-BHQ), an MRI-based normalized GMV, after controlling for age, sex, and facility, not only individually but also when they were entered into a single regression model. Moreover, there were small but significant differences in the proportion of the variance for GM-BHQ explained by variables in a regression model (measured by R squared) between when these unhealthy variables were entered in an equation at the same time and when they were entered separately, with the former larger than the latter. However, smoking and lack of exercise were not significantly associated with GM-BHQ. Results indicate that some kinds of unhealthy lifestyles are somewhat harmful on their own, but may become more noxious to brain condition if practiced simultaneously, although its difference may not be large. To our knowledge, this study is the first to show that overlapping unhealthy lifestyles affects the brains of healthy adults.Keisuke KokubunJuan Cesar D PinedaYoshinori YamakawaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0255285 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Keisuke Kokubun Juan Cesar D Pineda Yoshinori Yamakawa Unhealthy lifestyles and brain condition: Examining the relations of BMI, living alone, alcohol intake, short sleep, smoking, and lack of exercise with gray matter volume.
description	Unhealthy lifestyles are damaging to the brain. Previous studies have indicated that body mass index (BMI), alcohol intake, short sleep, smoking, and lack of exercise are negatively associated with gray matter volume (GMV). Living alone has also been found to be related to GMV through lowered subjective happiness. However, to our knowledge, no GMV study has dealt with these unhealthy lifestyles simultaneously. By our analyses based on 142 healthy Japanese participants, BMI, alcohol intake, living alone, and short sleep were negatively associated with the gray-matter brain healthcare quotient (GM-BHQ), an MRI-based normalized GMV, after controlling for age, sex, and facility, not only individually but also when they were entered into a single regression model. Moreover, there were small but significant differences in the proportion of the variance for GM-BHQ explained by variables in a regression model (measured by R squared) between when these unhealthy variables were entered in an equation at the same time and when they were entered separately, with the former larger than the latter. However, smoking and lack of exercise were not significantly associated with GM-BHQ. Results indicate that some kinds of unhealthy lifestyles are somewhat harmful on their own, but may become more noxious to brain condition if practiced simultaneously, although its difference may not be large. To our knowledge, this study is the first to show that overlapping unhealthy lifestyles affects the brains of healthy adults.
format	article
author	Keisuke Kokubun Juan Cesar D Pineda Yoshinori Yamakawa
author_facet	Keisuke Kokubun Juan Cesar D Pineda Yoshinori Yamakawa
author_sort	Keisuke Kokubun
title	Unhealthy lifestyles and brain condition: Examining the relations of BMI, living alone, alcohol intake, short sleep, smoking, and lack of exercise with gray matter volume.
title_short	Unhealthy lifestyles and brain condition: Examining the relations of BMI, living alone, alcohol intake, short sleep, smoking, and lack of exercise with gray matter volume.
title_full	Unhealthy lifestyles and brain condition: Examining the relations of BMI, living alone, alcohol intake, short sleep, smoking, and lack of exercise with gray matter volume.
title_fullStr	Unhealthy lifestyles and brain condition: Examining the relations of BMI, living alone, alcohol intake, short sleep, smoking, and lack of exercise with gray matter volume.
title_full_unstemmed	Unhealthy lifestyles and brain condition: Examining the relations of BMI, living alone, alcohol intake, short sleep, smoking, and lack of exercise with gray matter volume.
title_sort	unhealthy lifestyles and brain condition: examining the relations of bmi, living alone, alcohol intake, short sleep, smoking, and lack of exercise with gray matter volume.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/40829b4ac1fa43018432d407e19b61a5
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Unhealthy lifestyles and brain condition: Examining the relations of BMI, living alone, alcohol intake, short sleep, smoking, and lack of exercise with gray matter volume.

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