Transcranial ultrasound stimulation of the human motor cortex

Summary: It has been 40 years since the report of long-term synaptic plasticity on the rodent brain. Transcranial ultrasound stimulation (TUS) shows advantages in spatial resolution and penetration depth when compared with electrical or magnetic stimulation. The repetitive TUS (rTUS) can induce cort...

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Autores principales:	Yi Zhang, Liyuan Ren, Kai Liu, Shanbao Tong, Ti-Fei Yuan, Junfeng Sun
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Biological sciences Neuroscience Techniques in neuroscience Science Q
Acceso en línea:	https://doaj.org/article/4084c86843ef4b988a475b21ae02a512
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spelling	oai:doaj.org-article:4084c86843ef4b988a475b21ae02a5122021-11-26T04:37:54ZTranscranial ultrasound stimulation of the human motor cortex2589-004210.1016/j.isci.2021.103429https://doaj.org/article/4084c86843ef4b988a475b21ae02a5122021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2589004221014000https://doaj.org/toc/2589-0042Summary: It has been 40 years since the report of long-term synaptic plasticity on the rodent brain. Transcranial ultrasound stimulation (TUS) shows advantages in spatial resolution and penetration depth when compared with electrical or magnetic stimulation. The repetitive TUS (rTUS) can induce cortical excitability alteration on animals, and persistent aftereffects were observed. However, the effects of rTUS on synaptic plasticity in humans remain unelucidated. In the current study, we applied a 15-min rTUS protocol to stimulate left primary motor cortex (l-M1) in 24 male healthy participants. The single-pulsed transcranial magnetic stimulation-evoked motor evoked potential and Stop-signal task was applied to measure the rTUS aftereffects. Here, we report that conditioning the human motor cortex using rTUS may produce long-lasting and statistically significant effects on motor cortex excitability as well as motor behavior, without harmful side effects observed. These findings suggest a considerable potential of rTUS in cortical plasticity modulation and clinical intervention for impulsivity-related disorders.Yi ZhangLiyuan RenKai LiuShanbao TongTi-Fei YuanJunfeng SunElsevierarticleBiological sciencesNeuroscienceTechniques in neuroscienceScienceQENiScience, Vol 24, Iss 12, Pp 103429- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biological sciences Neuroscience Techniques in neuroscience Science Q
spellingShingle	Biological sciences Neuroscience Techniques in neuroscience Science Q Yi Zhang Liyuan Ren Kai Liu Shanbao Tong Ti-Fei Yuan Junfeng Sun Transcranial ultrasound stimulation of the human motor cortex
description	Summary: It has been 40 years since the report of long-term synaptic plasticity on the rodent brain. Transcranial ultrasound stimulation (TUS) shows advantages in spatial resolution and penetration depth when compared with electrical or magnetic stimulation. The repetitive TUS (rTUS) can induce cortical excitability alteration on animals, and persistent aftereffects were observed. However, the effects of rTUS on synaptic plasticity in humans remain unelucidated. In the current study, we applied a 15-min rTUS protocol to stimulate left primary motor cortex (l-M1) in 24 male healthy participants. The single-pulsed transcranial magnetic stimulation-evoked motor evoked potential and Stop-signal task was applied to measure the rTUS aftereffects. Here, we report that conditioning the human motor cortex using rTUS may produce long-lasting and statistically significant effects on motor cortex excitability as well as motor behavior, without harmful side effects observed. These findings suggest a considerable potential of rTUS in cortical plasticity modulation and clinical intervention for impulsivity-related disorders.
format	article
author	Yi Zhang Liyuan Ren Kai Liu Shanbao Tong Ti-Fei Yuan Junfeng Sun
author_facet	Yi Zhang Liyuan Ren Kai Liu Shanbao Tong Ti-Fei Yuan Junfeng Sun
author_sort	Yi Zhang
title	Transcranial ultrasound stimulation of the human motor cortex
title_short	Transcranial ultrasound stimulation of the human motor cortex
title_full	Transcranial ultrasound stimulation of the human motor cortex
title_fullStr	Transcranial ultrasound stimulation of the human motor cortex
title_full_unstemmed	Transcranial ultrasound stimulation of the human motor cortex
title_sort	transcranial ultrasound stimulation of the human motor cortex
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/4084c86843ef4b988a475b21ae02a512
work_keys_str_mv	AT yizhang transcranialultrasoundstimulationofthehumanmotorcortex AT liyuanren transcranialultrasoundstimulationofthehumanmotorcortex AT kailiu transcranialultrasoundstimulationofthehumanmotorcortex AT shanbaotong transcranialultrasoundstimulationofthehumanmotorcortex AT tifeiyuan transcranialultrasoundstimulationofthehumanmotorcortex AT junfengsun transcranialultrasoundstimulationofthehumanmotorcortex
_version_	1718409837084147712

Transcranial ultrasound stimulation of the human motor cortex

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