Phosphatidylcholine restores neuronal plasticity of neural stem cells under inflammatory stress

Abstract The balances between NSCs growth and differentiation, and between glial and neuronal differentiation play a key role in brain regeneration after any pathological conditions. It is well known that the nervous tissue shows a poor recovery after injury due to the factors present in the wounded...

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Autores principales:	Dario Magaquian, Susana Delgado Ocaña, Consuelo Perez, Claudia Banchio
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4089b24cd6754177a3bc3da9a299100e
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spelling	oai:doaj.org-article:4089b24cd6754177a3bc3da9a299100e2021-11-28T12:16:42ZPhosphatidylcholine restores neuronal plasticity of neural stem cells under inflammatory stress10.1038/s41598-021-02361-52045-2322https://doaj.org/article/4089b24cd6754177a3bc3da9a299100e2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02361-5https://doaj.org/toc/2045-2322Abstract The balances between NSCs growth and differentiation, and between glial and neuronal differentiation play a key role in brain regeneration after any pathological conditions. It is well known that the nervous tissue shows a poor recovery after injury due to the factors present in the wounded microenvironment, particularly inflammatory factors, that prevent neuronal differentiation. Thus, it is essential to generate a favourable condition for NSCs and conduct them to differentiate towards functional neurons. Here, we show that neuroinflammation has no effect on NSCs proliferation but induces an aberrant neuronal differentiation that gives rise to dystrophic, non-functional neurons. This is perhaps the initial step of brain failure associated to many neurological disorders. Interestingly, we demonstrate that phosphatidylcholine (PtdCho)-enriched media enhances neuronal differentiation even under inflammatory stress by modifying the commitment of post-mitotic cells. The pro-neurogenic effect of PtdCho increases the population of healthy normal neurons. In addition, we provide evidences that this phospholipid ameliorates the damage of neurons and, in consequence, modulates neuronal plasticity. These results contribute to our understanding of NSCs behaviour under inflammatory conditions, opening up new venues to improve neurogenic capacity in the brain.Dario MagaquianSusana Delgado OcañaConsuelo PerezClaudia BanchioNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dario Magaquian Susana Delgado Ocaña Consuelo Perez Claudia Banchio Phosphatidylcholine restores neuronal plasticity of neural stem cells under inflammatory stress
description	Abstract The balances between NSCs growth and differentiation, and between glial and neuronal differentiation play a key role in brain regeneration after any pathological conditions. It is well known that the nervous tissue shows a poor recovery after injury due to the factors present in the wounded microenvironment, particularly inflammatory factors, that prevent neuronal differentiation. Thus, it is essential to generate a favourable condition for NSCs and conduct them to differentiate towards functional neurons. Here, we show that neuroinflammation has no effect on NSCs proliferation but induces an aberrant neuronal differentiation that gives rise to dystrophic, non-functional neurons. This is perhaps the initial step of brain failure associated to many neurological disorders. Interestingly, we demonstrate that phosphatidylcholine (PtdCho)-enriched media enhances neuronal differentiation even under inflammatory stress by modifying the commitment of post-mitotic cells. The pro-neurogenic effect of PtdCho increases the population of healthy normal neurons. In addition, we provide evidences that this phospholipid ameliorates the damage of neurons and, in consequence, modulates neuronal plasticity. These results contribute to our understanding of NSCs behaviour under inflammatory conditions, opening up new venues to improve neurogenic capacity in the brain.
format	article
author	Dario Magaquian Susana Delgado Ocaña Consuelo Perez Claudia Banchio
author_facet	Dario Magaquian Susana Delgado Ocaña Consuelo Perez Claudia Banchio
author_sort	Dario Magaquian
title	Phosphatidylcholine restores neuronal plasticity of neural stem cells under inflammatory stress
title_short	Phosphatidylcholine restores neuronal plasticity of neural stem cells under inflammatory stress
title_full	Phosphatidylcholine restores neuronal plasticity of neural stem cells under inflammatory stress
title_fullStr	Phosphatidylcholine restores neuronal plasticity of neural stem cells under inflammatory stress
title_full_unstemmed	Phosphatidylcholine restores neuronal plasticity of neural stem cells under inflammatory stress
title_sort	phosphatidylcholine restores neuronal plasticity of neural stem cells under inflammatory stress
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4089b24cd6754177a3bc3da9a299100e
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_version_	1718408071716274176

Phosphatidylcholine restores neuronal plasticity of neural stem cells under inflammatory stress

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