Upper airway gene expression reveals suppressed immune responses to SARS-CoV-2 compared with other respiratory viruses

Here, the authors provide upper airway gene expression data from patients with COVID-19 and other viral and non-viral acute respiratory illnesses. They find attenuated activation of innate immune and pro-inflammatory pathways in COVID-19 as compared to other viral infections, which may contribute to...

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Autores principales:	Eran Mick, Jack Kamm, Angela Oliveira Pisco, Kalani Ratnasiri, Jennifer M. Babik, Gloria Castañeda, Joseph L. DeRisi, Angela M. Detweiler, Samantha L. Hao, Kirsten N. Kangelaris, G. Renuka Kumar, Lucy M. Li, Sabrina A. Mann, Norma Neff, Priya A. Prasad, Paula Hayakawa Serpa, Sachin J. Shah, Natasha Spottiswoode, Michelle Tan, Carolyn S. Calfee, Stephanie A. Christenson, Amy Kistler, Charles Langelier
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/408b6cd697fa4ad18907bc9b834782d0
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spelling	oai:doaj.org-article:408b6cd697fa4ad18907bc9b834782d02021-12-02T15:39:17ZUpper airway gene expression reveals suppressed immune responses to SARS-CoV-2 compared with other respiratory viruses10.1038/s41467-020-19587-y2041-1723https://doaj.org/article/408b6cd697fa4ad18907bc9b834782d02020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19587-yhttps://doaj.org/toc/2041-1723Here, the authors provide upper airway gene expression data from patients with COVID-19 and other viral and non-viral acute respiratory illnesses. They find attenuated activation of innate immune and pro-inflammatory pathways in COVID-19 as compared to other viral infections, which may contribute to its propensity for pre-symptomatic transmission.Eran MickJack KammAngela Oliveira PiscoKalani RatnasiriJennifer M. BabikGloria CastañedaJoseph L. DeRisiAngela M. DetweilerSamantha L. HaoKirsten N. KangelarisG. Renuka KumarLucy M. LiSabrina A. MannNorma NeffPriya A. PrasadPaula Hayakawa SerpaSachin J. ShahNatasha SpottiswoodeMichelle TanCarolyn S. CalfeeStephanie A. ChristensonAmy KistlerCharles LangelierNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-7 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Eran Mick Jack Kamm Angela Oliveira Pisco Kalani Ratnasiri Jennifer M. Babik Gloria Castañeda Joseph L. DeRisi Angela M. Detweiler Samantha L. Hao Kirsten N. Kangelaris G. Renuka Kumar Lucy M. Li Sabrina A. Mann Norma Neff Priya A. Prasad Paula Hayakawa Serpa Sachin J. Shah Natasha Spottiswoode Michelle Tan Carolyn S. Calfee Stephanie A. Christenson Amy Kistler Charles Langelier Upper airway gene expression reveals suppressed immune responses to SARS-CoV-2 compared with other respiratory viruses
description	Here, the authors provide upper airway gene expression data from patients with COVID-19 and other viral and non-viral acute respiratory illnesses. They find attenuated activation of innate immune and pro-inflammatory pathways in COVID-19 as compared to other viral infections, which may contribute to its propensity for pre-symptomatic transmission.
format	article
author	Eran Mick Jack Kamm Angela Oliveira Pisco Kalani Ratnasiri Jennifer M. Babik Gloria Castañeda Joseph L. DeRisi Angela M. Detweiler Samantha L. Hao Kirsten N. Kangelaris G. Renuka Kumar Lucy M. Li Sabrina A. Mann Norma Neff Priya A. Prasad Paula Hayakawa Serpa Sachin J. Shah Natasha Spottiswoode Michelle Tan Carolyn S. Calfee Stephanie A. Christenson Amy Kistler Charles Langelier
author_facet	Eran Mick Jack Kamm Angela Oliveira Pisco Kalani Ratnasiri Jennifer M. Babik Gloria Castañeda Joseph L. DeRisi Angela M. Detweiler Samantha L. Hao Kirsten N. Kangelaris G. Renuka Kumar Lucy M. Li Sabrina A. Mann Norma Neff Priya A. Prasad Paula Hayakawa Serpa Sachin J. Shah Natasha Spottiswoode Michelle Tan Carolyn S. Calfee Stephanie A. Christenson Amy Kistler Charles Langelier
author_sort	Eran Mick
title	Upper airway gene expression reveals suppressed immune responses to SARS-CoV-2 compared with other respiratory viruses
title_short	Upper airway gene expression reveals suppressed immune responses to SARS-CoV-2 compared with other respiratory viruses
title_full	Upper airway gene expression reveals suppressed immune responses to SARS-CoV-2 compared with other respiratory viruses
title_fullStr	Upper airway gene expression reveals suppressed immune responses to SARS-CoV-2 compared with other respiratory viruses
title_full_unstemmed	Upper airway gene expression reveals suppressed immune responses to SARS-CoV-2 compared with other respiratory viruses
title_sort	upper airway gene expression reveals suppressed immune responses to sars-cov-2 compared with other respiratory viruses
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/408b6cd697fa4ad18907bc9b834782d0
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Upper airway gene expression reveals suppressed immune responses to SARS-CoV-2 compared with other respiratory viruses

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