Factors Associated with the Expression of ACE2 in Human Lung Tissue: Pathological Evidence from Patients with Normal FEV1 and FEV1/FVC
Wuping Bao,1,* Xue Zhang,1,* Yubiao Jin,2,* Huijuan Hao,1 Fu Yang,3 Dongning Yin,1 Xi Chen,3 Yishu Xue,1 Lei Han,1 Min Zhang1 1Department of Respiratory and Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of C...
Guardado en:
| Autores principales: | , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Dove Medical Press
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/408e0a3d7b0d4b90aa725fab7927368b |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:408e0a3d7b0d4b90aa725fab7927368b |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:408e0a3d7b0d4b90aa725fab7927368b2021-12-02T15:29:03ZFactors Associated with the Expression of ACE2 in Human Lung Tissue: Pathological Evidence from Patients with Normal FEV1 and FEV1/FVC1178-7031https://doaj.org/article/408e0a3d7b0d4b90aa725fab7927368b2021-04-01T00:00:00Zhttps://www.dovepress.com/factors-associated-with-the-expression-of-ace2-in-human-lung-tissue-pa-peer-reviewed-fulltext-article-JIRhttps://doaj.org/toc/1178-7031Wuping Bao,1,* Xue Zhang,1,* Yubiao Jin,2,* Huijuan Hao,1 Fu Yang,3 Dongning Yin,1 Xi Chen,3 Yishu Xue,1 Lei Han,1 Min Zhang1 1Department of Respiratory and Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 2Department of Pathology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 3Department of Thoracic Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Min ZhangDepartment of Respiratory and Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 100, Haining Road, Shanghai, 200080, People’s Republic of ChinaEmail maggie_zhangmin@163.comBackground: Whether COVID-19 comorbidities and risk factors such as old age, male gender, smoking, obesity, eosinophils and blood types have direct contact with expression of ACE2 and pro-inflammation cytokines in human lung tissues were still unclear.Patients and Methods: Sixty-four patients with normal FEV1 and FEV1/FVC underwent thoracotomy for pulmonary nodules were included. Blinded histological assessments were performed by two pathologists. Clinical features and results of the immunohistochemical staining of ACE2 were collected and analyzed.Results: ACE2 expressed in alveolar macrophages (most obvious), alveolar epithelia and vascular endothelia, but not in small-airway epithelia. ACE2 expressions are positively related to age (r =0.26, P =0.040), weight (r =0.43, P< 0.001), as well as BMI (r = 0.38, P =0.002), and male patients show higher expressions of ACE2 in lungs (P < 0.05). ACE2 expressions are negatively related to peripheral eosinophils (r = − 0.30, P =0.017). There was no correlation between ABO blood types and ACE2 expression in normal lung tissues (P > 0.05). IL-13 and IL-6R expression in lung tissue increased with age (r =0.26, P < 0.05, for both).Conclusion: Our pathological evidences showed that the alveolar epithelia, vascular endothelia, and alveolar macrophages are susceptible in human lungs for SARS-CoV-2 infection. The risk factors such as high body weight/BMI, old age, male gender, and eosinopenia may be related to ACE2 expression in human lungs, and associated with more chance to develop the severe cases. IL-6R expression in lung tissue also increased with age. Therefore, weight control and smoking cessation are essential to reduce the susceptibility of SARS-CoV-2 infection, especially in obesity, old or male patients. Peripheral eosinophils monitor is also quite necessary to detect severe tendency in COVID-19 patients.Keywords: ACE2, risk factor, BMI, age, sex, eosinophilsBao WZhang XJin YHao HYang FYin DChen XXue YHan LZhang MDove Medical Pressarticleace2risk factorbmiagesexeosinophilsPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 14, Pp 1677-1687 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
ace2 risk factor bmi age sex eosinophils Pathology RB1-214 Therapeutics. Pharmacology RM1-950 |
| spellingShingle |
ace2 risk factor bmi age sex eosinophils Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Bao W Zhang X Jin Y Hao H Yang F Yin D Chen X Xue Y Han L Zhang M Factors Associated with the Expression of ACE2 in Human Lung Tissue: Pathological Evidence from Patients with Normal FEV1 and FEV1/FVC |
| description |
Wuping Bao,1,* Xue Zhang,1,* Yubiao Jin,2,* Huijuan Hao,1 Fu Yang,3 Dongning Yin,1 Xi Chen,3 Yishu Xue,1 Lei Han,1 Min Zhang1 1Department of Respiratory and Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 2Department of Pathology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 3Department of Thoracic Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Min ZhangDepartment of Respiratory and Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 100, Haining Road, Shanghai, 200080, People’s Republic of ChinaEmail maggie_zhangmin@163.comBackground: Whether COVID-19 comorbidities and risk factors such as old age, male gender, smoking, obesity, eosinophils and blood types have direct contact with expression of ACE2 and pro-inflammation cytokines in human lung tissues were still unclear.Patients and Methods: Sixty-four patients with normal FEV1 and FEV1/FVC underwent thoracotomy for pulmonary nodules were included. Blinded histological assessments were performed by two pathologists. Clinical features and results of the immunohistochemical staining of ACE2 were collected and analyzed.Results: ACE2 expressed in alveolar macrophages (most obvious), alveolar epithelia and vascular endothelia, but not in small-airway epithelia. ACE2 expressions are positively related to age (r =0.26, P =0.040), weight (r =0.43, P< 0.001), as well as BMI (r = 0.38, P =0.002), and male patients show higher expressions of ACE2 in lungs (P < 0.05). ACE2 expressions are negatively related to peripheral eosinophils (r = − 0.30, P =0.017). There was no correlation between ABO blood types and ACE2 expression in normal lung tissues (P > 0.05). IL-13 and IL-6R expression in lung tissue increased with age (r =0.26, P < 0.05, for both).Conclusion: Our pathological evidences showed that the alveolar epithelia, vascular endothelia, and alveolar macrophages are susceptible in human lungs for SARS-CoV-2 infection. The risk factors such as high body weight/BMI, old age, male gender, and eosinopenia may be related to ACE2 expression in human lungs, and associated with more chance to develop the severe cases. IL-6R expression in lung tissue also increased with age. Therefore, weight control and smoking cessation are essential to reduce the susceptibility of SARS-CoV-2 infection, especially in obesity, old or male patients. Peripheral eosinophils monitor is also quite necessary to detect severe tendency in COVID-19 patients.Keywords: ACE2, risk factor, BMI, age, sex, eosinophils |
| format |
article |
| author |
Bao W Zhang X Jin Y Hao H Yang F Yin D Chen X Xue Y Han L Zhang M |
| author_facet |
Bao W Zhang X Jin Y Hao H Yang F Yin D Chen X Xue Y Han L Zhang M |
| author_sort |
Bao W |
| title |
Factors Associated with the Expression of ACE2 in Human Lung Tissue: Pathological Evidence from Patients with Normal FEV1 and FEV1/FVC |
| title_short |
Factors Associated with the Expression of ACE2 in Human Lung Tissue: Pathological Evidence from Patients with Normal FEV1 and FEV1/FVC |
| title_full |
Factors Associated with the Expression of ACE2 in Human Lung Tissue: Pathological Evidence from Patients with Normal FEV1 and FEV1/FVC |
| title_fullStr |
Factors Associated with the Expression of ACE2 in Human Lung Tissue: Pathological Evidence from Patients with Normal FEV1 and FEV1/FVC |
| title_full_unstemmed |
Factors Associated with the Expression of ACE2 in Human Lung Tissue: Pathological Evidence from Patients with Normal FEV1 and FEV1/FVC |
| title_sort |
factors associated with the expression of ace2 in human lung tissue: pathological evidence from patients with normal fev1 and fev1/fvc |
| publisher |
Dove Medical Press |
| publishDate |
2021 |
| url |
https://doaj.org/article/408e0a3d7b0d4b90aa725fab7927368b |
| work_keys_str_mv |
AT baow factorsassociatedwiththeexpressionoface2inhumanlungtissuepathologicalevidencefrompatientswithnormalfev1andfev1fvc AT zhangx factorsassociatedwiththeexpressionoface2inhumanlungtissuepathologicalevidencefrompatientswithnormalfev1andfev1fvc AT jiny factorsassociatedwiththeexpressionoface2inhumanlungtissuepathologicalevidencefrompatientswithnormalfev1andfev1fvc AT haoh factorsassociatedwiththeexpressionoface2inhumanlungtissuepathologicalevidencefrompatientswithnormalfev1andfev1fvc AT yangf factorsassociatedwiththeexpressionoface2inhumanlungtissuepathologicalevidencefrompatientswithnormalfev1andfev1fvc AT yind factorsassociatedwiththeexpressionoface2inhumanlungtissuepathologicalevidencefrompatientswithnormalfev1andfev1fvc AT chenx factorsassociatedwiththeexpressionoface2inhumanlungtissuepathologicalevidencefrompatientswithnormalfev1andfev1fvc AT xuey factorsassociatedwiththeexpressionoface2inhumanlungtissuepathologicalevidencefrompatientswithnormalfev1andfev1fvc AT hanl factorsassociatedwiththeexpressionoface2inhumanlungtissuepathologicalevidencefrompatientswithnormalfev1andfev1fvc AT zhangm factorsassociatedwiththeexpressionoface2inhumanlungtissuepathologicalevidencefrompatientswithnormalfev1andfev1fvc |
| _version_ |
1718387137748926464 |