Targeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertension

Cells of the pulmonary vasculature show a hyperproliferative phenotype in pulmonary arterial hypertension (PAH), thus contributing to the disease pathogenesis. Here the authors show that cyclin-dependent kinases are overactivated in PAH, and that their pharmacological inhibition attenuates the disea...

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Autores principales:	Astrid Weiss, Moritz Christian Neubauer, Dinesh Yerabolu, Baktybek Kojonazarov, Beate Christiane Schlueter, Lavinia Neubert, Danny Jonigk, Nelli Baal, Clemens Ruppert, Peter Dorfmuller, Soni Savai Pullamsetti, Norbert Weissmann, Hossein-Ardeschir Ghofrani, Friedrich Grimminger, Werner Seeger, Ralph Theo Schermuly
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4090a81f202846ada6a47e71478ee836
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spelling	oai:doaj.org-article:4090a81f202846ada6a47e71478ee8362021-12-02T17:32:23ZTargeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertension10.1038/s41467-019-10135-x2041-1723https://doaj.org/article/4090a81f202846ada6a47e71478ee8362019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10135-xhttps://doaj.org/toc/2041-1723Cells of the pulmonary vasculature show a hyperproliferative phenotype in pulmonary arterial hypertension (PAH), thus contributing to the disease pathogenesis. Here the authors show that cyclin-dependent kinases are overactivated in PAH, and that their pharmacological inhibition attenuates the disease in two independent rodent modelsAstrid WeissMoritz Christian NeubauerDinesh YeraboluBaktybek KojonazarovBeate Christiane SchlueterLavinia NeubertDanny JonigkNelli BaalClemens RuppertPeter DorfmullerSoni Savai PullamsettiNorbert WeissmannHossein-Ardeschir GhofraniFriedrich GrimmingerWerner SeegerRalph Theo SchermulyNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Astrid Weiss Moritz Christian Neubauer Dinesh Yerabolu Baktybek Kojonazarov Beate Christiane Schlueter Lavinia Neubert Danny Jonigk Nelli Baal Clemens Ruppert Peter Dorfmuller Soni Savai Pullamsetti Norbert Weissmann Hossein-Ardeschir Ghofrani Friedrich Grimminger Werner Seeger Ralph Theo Schermuly Targeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertension
description	Cells of the pulmonary vasculature show a hyperproliferative phenotype in pulmonary arterial hypertension (PAH), thus contributing to the disease pathogenesis. Here the authors show that cyclin-dependent kinases are overactivated in PAH, and that their pharmacological inhibition attenuates the disease in two independent rodent models
format	article
author	Astrid Weiss Moritz Christian Neubauer Dinesh Yerabolu Baktybek Kojonazarov Beate Christiane Schlueter Lavinia Neubert Danny Jonigk Nelli Baal Clemens Ruppert Peter Dorfmuller Soni Savai Pullamsetti Norbert Weissmann Hossein-Ardeschir Ghofrani Friedrich Grimminger Werner Seeger Ralph Theo Schermuly
author_facet	Astrid Weiss Moritz Christian Neubauer Dinesh Yerabolu Baktybek Kojonazarov Beate Christiane Schlueter Lavinia Neubert Danny Jonigk Nelli Baal Clemens Ruppert Peter Dorfmuller Soni Savai Pullamsetti Norbert Weissmann Hossein-Ardeschir Ghofrani Friedrich Grimminger Werner Seeger Ralph Theo Schermuly
author_sort	Astrid Weiss
title	Targeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertension
title_short	Targeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertension
title_full	Targeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertension
title_fullStr	Targeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertension
title_full_unstemmed	Targeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertension
title_sort	targeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertension
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/4090a81f202846ada6a47e71478ee836
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Targeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertension

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