Adaptive Immune Deficiency Impairs Neural Activity After Training and Retrieval

Neuroimmune interactions have been studied for decades. Several neurodevelopmental disorders have been associated with immune dysfunction. However, the effects of immune system on neuronal function remain unknown. Herein, based on c-Fos protein expression, we characterized the brain areas that are a...

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Autores principales:	Huiping Li, Zhongxiao Fu, Meixin Hu, Xiu Xu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	adaptive immune c-Fos neural activity contextual fear conditioning neurodevelopmental disorders Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/40919e89d8c04840b26cb18b3b527b30
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spelling	oai:doaj.org-article:40919e89d8c04840b26cb18b3b527b302021-11-15T06:34:51ZAdaptive Immune Deficiency Impairs Neural Activity After Training and Retrieval1662-453X10.3389/fnins.2021.739580https://doaj.org/article/40919e89d8c04840b26cb18b3b527b302021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnins.2021.739580/fullhttps://doaj.org/toc/1662-453XNeuroimmune interactions have been studied for decades. Several neurodevelopmental disorders have been associated with immune dysfunction. However, the effects of immune system on neuronal function remain unknown. Herein, based on c-Fos protein expression, we characterized the brain areas that are activated after contextual fear conditioning (CFC) training or retrieval in severe combined immune deficiency (SCID) and wild-type mice. Further, we analyzed the interregional correlations of c-Fos activity that are affected by deficiency in adaptive immunity. Results showed significantly lower c-Fos density in learning and memory-associated brain regions of SCID mice after memory retrieval, but not during the CFC training. Moreover, SCID mice exhibited remarkably discordant interregional neuronal activities of learning neuron circuits after CFC training, which could be the cause of inefficient activation of the memory circuit after retrieval. These results provide a new perspective on how adaptive immunity affects neuronal function. Adaptive immune deficiency impairs the coordination of neural activity after training and retrieval, which might be a potential therapeutic target for neurodevelopmental disorders.Huiping LiZhongxiao FuMeixin HuXiu XuFrontiers Media S.A.articleadaptive immunec-Fosneural activitycontextual fear conditioningneurodevelopmental disordersNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Neuroscience, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	adaptive immune c-Fos neural activity contextual fear conditioning neurodevelopmental disorders Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	adaptive immune c-Fos neural activity contextual fear conditioning neurodevelopmental disorders Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Huiping Li Zhongxiao Fu Meixin Hu Xiu Xu Adaptive Immune Deficiency Impairs Neural Activity After Training and Retrieval
description	Neuroimmune interactions have been studied for decades. Several neurodevelopmental disorders have been associated with immune dysfunction. However, the effects of immune system on neuronal function remain unknown. Herein, based on c-Fos protein expression, we characterized the brain areas that are activated after contextual fear conditioning (CFC) training or retrieval in severe combined immune deficiency (SCID) and wild-type mice. Further, we analyzed the interregional correlations of c-Fos activity that are affected by deficiency in adaptive immunity. Results showed significantly lower c-Fos density in learning and memory-associated brain regions of SCID mice after memory retrieval, but not during the CFC training. Moreover, SCID mice exhibited remarkably discordant interregional neuronal activities of learning neuron circuits after CFC training, which could be the cause of inefficient activation of the memory circuit after retrieval. These results provide a new perspective on how adaptive immunity affects neuronal function. Adaptive immune deficiency impairs the coordination of neural activity after training and retrieval, which might be a potential therapeutic target for neurodevelopmental disorders.
format	article
author	Huiping Li Zhongxiao Fu Meixin Hu Xiu Xu
author_facet	Huiping Li Zhongxiao Fu Meixin Hu Xiu Xu
author_sort	Huiping Li
title	Adaptive Immune Deficiency Impairs Neural Activity After Training and Retrieval
title_short	Adaptive Immune Deficiency Impairs Neural Activity After Training and Retrieval
title_full	Adaptive Immune Deficiency Impairs Neural Activity After Training and Retrieval
title_fullStr	Adaptive Immune Deficiency Impairs Neural Activity After Training and Retrieval
title_full_unstemmed	Adaptive Immune Deficiency Impairs Neural Activity After Training and Retrieval
title_sort	adaptive immune deficiency impairs neural activity after training and retrieval
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/40919e89d8c04840b26cb18b3b527b30
work_keys_str_mv	AT huipingli adaptiveimmunedeficiencyimpairsneuralactivityaftertrainingandretrieval AT zhongxiaofu adaptiveimmunedeficiencyimpairsneuralactivityaftertrainingandretrieval AT meixinhu adaptiveimmunedeficiencyimpairsneuralactivityaftertrainingandretrieval AT xiuxu adaptiveimmunedeficiencyimpairsneuralactivityaftertrainingandretrieval
_version_	1718428547102539776

Adaptive Immune Deficiency Impairs Neural Activity After Training and Retrieval

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