A preliminary study comparing the sedative, cardiorespiratory, and histaminic-releasing effects of intramuscular and intravenous administration of pethidine (meperidine) with midazolam in healthy cats

Pethidine is a synthetic opioid that is widely used in cats. However, the sedative, cardiorespiratory, and histaminic effects following administration of pethidine with midazolam in cats remain unclear. The objectives of this study were to evaluate and compare changes before and after intravenous (I...

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Autores principales:	Nian-Yao Yang, Jeff C. Ko, Hsien-Chi Wang, Pin-Chen Liu
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Pethidine Midazolam Intravenous Sedation Histamine Cat Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/409591489ed3431ab0d1165fabe7bbfb
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spelling	oai:doaj.org-article:409591489ed3431ab0d1165fabe7bbfb2021-11-14T04:34:44ZA preliminary study comparing the sedative, cardiorespiratory, and histaminic-releasing effects of intramuscular and intravenous administration of pethidine (meperidine) with midazolam in healthy cats2451-943X10.1016/j.vas.2021.100218https://doaj.org/article/409591489ed3431ab0d1165fabe7bbfb2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2451943X21000533https://doaj.org/toc/2451-943XPethidine is a synthetic opioid that is widely used in cats. However, the sedative, cardiorespiratory, and histaminic effects following administration of pethidine with midazolam in cats remain unclear. The objectives of this study were to evaluate and compare changes before and after intravenous (IV) and intramuscular (IM) administration of pethidine with midazolam in healthy cats. In this prospective randomized blind study, 12 cats were assigned equally to either the IV or IM treatment group. The IV group received pethidine 3 mg/kg and midazolam 0.1 mg/kg. The IM group received pethidine 6 mg/kg and midazolam 0.2 mg/kg. The sedative effects, heart rate, respiratory rate, non-invasive arterial blood pressures, and behavioral signs were recorded before and at 2, 5, 15, 30, 45, and 60 min after the injection. Blood samples were taken for an ELISA histamine assay at baseline and at 5 and 15 min after treatment. Cats that received IV treatment were rapidly induced a moderate degree of sedation but those received IM treatment were only mildly sedated. There was no significant difference in the cardiorespiratory values within and between the treatments over time. Plasma histamine concentrations increased by 3 and 5 times at 5 and 15 min after IV treatment, respectively, compared to baseline values. IM injections induced minimal changes in the plasma histamine concentration. In summary, intravenous pethidine with midazolam induced potentially superior sedative effects without serious side effects in clinically healthy cats. However, further studies with larger sample sizes are required to validate this finding.Nian-Yao YangJeff C. KoHsien-Chi WangPin-Chen LiuElsevierarticlePethidineMidazolamIntravenousSedationHistamineCatVeterinary medicineSF600-1100ENVeterinary and Animal Science, Vol 14, Iss , Pp 100218- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pethidine Midazolam Intravenous Sedation Histamine Cat Veterinary medicine SF600-1100
spellingShingle	Pethidine Midazolam Intravenous Sedation Histamine Cat Veterinary medicine SF600-1100 Nian-Yao Yang Jeff C. Ko Hsien-Chi Wang Pin-Chen Liu A preliminary study comparing the sedative, cardiorespiratory, and histaminic-releasing effects of intramuscular and intravenous administration of pethidine (meperidine) with midazolam in healthy cats
description	Pethidine is a synthetic opioid that is widely used in cats. However, the sedative, cardiorespiratory, and histaminic effects following administration of pethidine with midazolam in cats remain unclear. The objectives of this study were to evaluate and compare changes before and after intravenous (IV) and intramuscular (IM) administration of pethidine with midazolam in healthy cats. In this prospective randomized blind study, 12 cats were assigned equally to either the IV or IM treatment group. The IV group received pethidine 3 mg/kg and midazolam 0.1 mg/kg. The IM group received pethidine 6 mg/kg and midazolam 0.2 mg/kg. The sedative effects, heart rate, respiratory rate, non-invasive arterial blood pressures, and behavioral signs were recorded before and at 2, 5, 15, 30, 45, and 60 min after the injection. Blood samples were taken for an ELISA histamine assay at baseline and at 5 and 15 min after treatment. Cats that received IV treatment were rapidly induced a moderate degree of sedation but those received IM treatment were only mildly sedated. There was no significant difference in the cardiorespiratory values within and between the treatments over time. Plasma histamine concentrations increased by 3 and 5 times at 5 and 15 min after IV treatment, respectively, compared to baseline values. IM injections induced minimal changes in the plasma histamine concentration. In summary, intravenous pethidine with midazolam induced potentially superior sedative effects without serious side effects in clinically healthy cats. However, further studies with larger sample sizes are required to validate this finding.
format	article
author	Nian-Yao Yang Jeff C. Ko Hsien-Chi Wang Pin-Chen Liu
author_facet	Nian-Yao Yang Jeff C. Ko Hsien-Chi Wang Pin-Chen Liu
author_sort	Nian-Yao Yang
title	A preliminary study comparing the sedative, cardiorespiratory, and histaminic-releasing effects of intramuscular and intravenous administration of pethidine (meperidine) with midazolam in healthy cats
title_short	A preliminary study comparing the sedative, cardiorespiratory, and histaminic-releasing effects of intramuscular and intravenous administration of pethidine (meperidine) with midazolam in healthy cats
title_full	A preliminary study comparing the sedative, cardiorespiratory, and histaminic-releasing effects of intramuscular and intravenous administration of pethidine (meperidine) with midazolam in healthy cats
title_fullStr	A preliminary study comparing the sedative, cardiorespiratory, and histaminic-releasing effects of intramuscular and intravenous administration of pethidine (meperidine) with midazolam in healthy cats
title_full_unstemmed	A preliminary study comparing the sedative, cardiorespiratory, and histaminic-releasing effects of intramuscular and intravenous administration of pethidine (meperidine) with midazolam in healthy cats
title_sort	preliminary study comparing the sedative, cardiorespiratory, and histaminic-releasing effects of intramuscular and intravenous administration of pethidine (meperidine) with midazolam in healthy cats
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/409591489ed3431ab0d1165fabe7bbfb
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A preliminary study comparing the sedative, cardiorespiratory, and histaminic-releasing effects of intramuscular and intravenous administration of pethidine (meperidine) with midazolam in healthy cats

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