Dysregulation of mitochondria-lysosome contacts by GBA1 dysfunction in dopaminergic neuronal models of Parkinson’s disease

Mitochondria-lysosome contact sites mediate cross-talk between the two organelles. Here, the authors show mitochondria-lysosome contacts are prolonged and defective in heterozygous mutant GBA1 neurons, which is caused by defective modulation of TBC1D15 due to decreased GBA1 activity.

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Autores principales: Soojin Kim, Yvette C. Wong, Fanding Gao, Dimitri Krainc
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/40982e38dcd44c1f9dff1e73b1f33d9a
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spelling oai:doaj.org-article:40982e38dcd44c1f9dff1e73b1f33d9a2021-12-02T11:44:50ZDysregulation of mitochondria-lysosome contacts by GBA1 dysfunction in dopaminergic neuronal models of Parkinson’s disease10.1038/s41467-021-22113-32041-1723https://doaj.org/article/40982e38dcd44c1f9dff1e73b1f33d9a2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22113-3https://doaj.org/toc/2041-1723Mitochondria-lysosome contact sites mediate cross-talk between the two organelles. Here, the authors show mitochondria-lysosome contacts are prolonged and defective in heterozygous mutant GBA1 neurons, which is caused by defective modulation of TBC1D15 due to decreased GBA1 activity.Soojin KimYvette C. WongFanding GaoDimitri KraincNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Soojin Kim
Yvette C. Wong
Fanding Gao
Dimitri Krainc
Dysregulation of mitochondria-lysosome contacts by GBA1 dysfunction in dopaminergic neuronal models of Parkinson’s disease
description Mitochondria-lysosome contact sites mediate cross-talk between the two organelles. Here, the authors show mitochondria-lysosome contacts are prolonged and defective in heterozygous mutant GBA1 neurons, which is caused by defective modulation of TBC1D15 due to decreased GBA1 activity.
format article
author Soojin Kim
Yvette C. Wong
Fanding Gao
Dimitri Krainc
author_facet Soojin Kim
Yvette C. Wong
Fanding Gao
Dimitri Krainc
author_sort Soojin Kim
title Dysregulation of mitochondria-lysosome contacts by GBA1 dysfunction in dopaminergic neuronal models of Parkinson’s disease
title_short Dysregulation of mitochondria-lysosome contacts by GBA1 dysfunction in dopaminergic neuronal models of Parkinson’s disease
title_full Dysregulation of mitochondria-lysosome contacts by GBA1 dysfunction in dopaminergic neuronal models of Parkinson’s disease
title_fullStr Dysregulation of mitochondria-lysosome contacts by GBA1 dysfunction in dopaminergic neuronal models of Parkinson’s disease
title_full_unstemmed Dysregulation of mitochondria-lysosome contacts by GBA1 dysfunction in dopaminergic neuronal models of Parkinson’s disease
title_sort dysregulation of mitochondria-lysosome contacts by gba1 dysfunction in dopaminergic neuronal models of parkinson’s disease
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/40982e38dcd44c1f9dff1e73b1f33d9a
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AT fandinggao dysregulationofmitochondrialysosomecontactsbygba1dysfunctionindopaminergicneuronalmodelsofparkinsonsdisease
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