Dysregulation of mitochondria-lysosome contacts by GBA1 dysfunction in dopaminergic neuronal models of Parkinson’s disease
Mitochondria-lysosome contact sites mediate cross-talk between the two organelles. Here, the authors show mitochondria-lysosome contacts are prolonged and defective in heterozygous mutant GBA1 neurons, which is caused by defective modulation of TBC1D15 due to decreased GBA1 activity.
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Nature Portfolio
2021
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oai:doaj.org-article:40982e38dcd44c1f9dff1e73b1f33d9a2021-12-02T11:44:50ZDysregulation of mitochondria-lysosome contacts by GBA1 dysfunction in dopaminergic neuronal models of Parkinson’s disease10.1038/s41467-021-22113-32041-1723https://doaj.org/article/40982e38dcd44c1f9dff1e73b1f33d9a2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22113-3https://doaj.org/toc/2041-1723Mitochondria-lysosome contact sites mediate cross-talk between the two organelles. Here, the authors show mitochondria-lysosome contacts are prolonged and defective in heterozygous mutant GBA1 neurons, which is caused by defective modulation of TBC1D15 due to decreased GBA1 activity.Soojin KimYvette C. WongFanding GaoDimitri KraincNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021) |
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Science Q Soojin Kim Yvette C. Wong Fanding Gao Dimitri Krainc Dysregulation of mitochondria-lysosome contacts by GBA1 dysfunction in dopaminergic neuronal models of Parkinson’s disease |
description |
Mitochondria-lysosome contact sites mediate cross-talk between the two organelles. Here, the authors show mitochondria-lysosome contacts are prolonged and defective in heterozygous mutant GBA1 neurons, which is caused by defective modulation of TBC1D15 due to decreased GBA1 activity. |
format |
article |
author |
Soojin Kim Yvette C. Wong Fanding Gao Dimitri Krainc |
author_facet |
Soojin Kim Yvette C. Wong Fanding Gao Dimitri Krainc |
author_sort |
Soojin Kim |
title |
Dysregulation of mitochondria-lysosome contacts by GBA1 dysfunction in dopaminergic neuronal models of Parkinson’s disease |
title_short |
Dysregulation of mitochondria-lysosome contacts by GBA1 dysfunction in dopaminergic neuronal models of Parkinson’s disease |
title_full |
Dysregulation of mitochondria-lysosome contacts by GBA1 dysfunction in dopaminergic neuronal models of Parkinson’s disease |
title_fullStr |
Dysregulation of mitochondria-lysosome contacts by GBA1 dysfunction in dopaminergic neuronal models of Parkinson’s disease |
title_full_unstemmed |
Dysregulation of mitochondria-lysosome contacts by GBA1 dysfunction in dopaminergic neuronal models of Parkinson’s disease |
title_sort |
dysregulation of mitochondria-lysosome contacts by gba1 dysfunction in dopaminergic neuronal models of parkinson’s disease |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/40982e38dcd44c1f9dff1e73b1f33d9a |
work_keys_str_mv |
AT soojinkim dysregulationofmitochondrialysosomecontactsbygba1dysfunctionindopaminergicneuronalmodelsofparkinsonsdisease AT yvettecwong dysregulationofmitochondrialysosomecontactsbygba1dysfunctionindopaminergicneuronalmodelsofparkinsonsdisease AT fandinggao dysregulationofmitochondrialysosomecontactsbygba1dysfunctionindopaminergicneuronalmodelsofparkinsonsdisease AT dimitrikrainc dysregulationofmitochondrialysosomecontactsbygba1dysfunctionindopaminergicneuronalmodelsofparkinsonsdisease |
_version_ |
1718395276326076416 |