Dysregulation of mitochondria-lysosome contacts by GBA1 dysfunction in dopaminergic neuronal models of Parkinson’s disease

Mitochondria-lysosome contact sites mediate cross-talk between the two organelles. Here, the authors show mitochondria-lysosome contacts are prolonged and defective in heterozygous mutant GBA1 neurons, which is caused by defective modulation of TBC1D15 due to decreased GBA1 activity.

Enregistré dans:

Détails bibliographiques
Auteurs principaux:	Soojin Kim, Yvette C. Wong, Fanding Gao, Dimitri Krainc
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/40982e38dcd44c1f9dff1e73b1f33d9a
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!

id	oai:doaj.org-article:40982e38dcd44c1f9dff1e73b1f33d9a
record_format	dspace
spelling	oai:doaj.org-article:40982e38dcd44c1f9dff1e73b1f33d9a2021-12-02T11:44:50ZDysregulation of mitochondria-lysosome contacts by GBA1 dysfunction in dopaminergic neuronal models of Parkinson’s disease10.1038/s41467-021-22113-32041-1723https://doaj.org/article/40982e38dcd44c1f9dff1e73b1f33d9a2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22113-3https://doaj.org/toc/2041-1723Mitochondria-lysosome contact sites mediate cross-talk between the two organelles. Here, the authors show mitochondria-lysosome contacts are prolonged and defective in heterozygous mutant GBA1 neurons, which is caused by defective modulation of TBC1D15 due to decreased GBA1 activity.Soojin KimYvette C. WongFanding GaoDimitri KraincNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Soojin Kim Yvette C. Wong Fanding Gao Dimitri Krainc Dysregulation of mitochondria-lysosome contacts by GBA1 dysfunction in dopaminergic neuronal models of Parkinson’s disease
description	Mitochondria-lysosome contact sites mediate cross-talk between the two organelles. Here, the authors show mitochondria-lysosome contacts are prolonged and defective in heterozygous mutant GBA1 neurons, which is caused by defective modulation of TBC1D15 due to decreased GBA1 activity.
format	article
author	Soojin Kim Yvette C. Wong Fanding Gao Dimitri Krainc
author_facet	Soojin Kim Yvette C. Wong Fanding Gao Dimitri Krainc
author_sort	Soojin Kim
title	Dysregulation of mitochondria-lysosome contacts by GBA1 dysfunction in dopaminergic neuronal models of Parkinson’s disease
title_short	Dysregulation of mitochondria-lysosome contacts by GBA1 dysfunction in dopaminergic neuronal models of Parkinson’s disease
title_full	Dysregulation of mitochondria-lysosome contacts by GBA1 dysfunction in dopaminergic neuronal models of Parkinson’s disease
title_fullStr	Dysregulation of mitochondria-lysosome contacts by GBA1 dysfunction in dopaminergic neuronal models of Parkinson’s disease
title_full_unstemmed	Dysregulation of mitochondria-lysosome contacts by GBA1 dysfunction in dopaminergic neuronal models of Parkinson’s disease
title_sort	dysregulation of mitochondria-lysosome contacts by gba1 dysfunction in dopaminergic neuronal models of parkinson’s disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/40982e38dcd44c1f9dff1e73b1f33d9a
work_keys_str_mv	AT soojinkim dysregulationofmitochondrialysosomecontactsbygba1dysfunctionindopaminergicneuronalmodelsofparkinsonsdisease AT yvettecwong dysregulationofmitochondrialysosomecontactsbygba1dysfunctionindopaminergicneuronalmodelsofparkinsonsdisease AT fandinggao dysregulationofmitochondrialysosomecontactsbygba1dysfunctionindopaminergicneuronalmodelsofparkinsonsdisease AT dimitrikrainc dysregulationofmitochondrialysosomecontactsbygba1dysfunctionindopaminergicneuronalmodelsofparkinsonsdisease
_version_	1718395276326076416

Dysregulation of mitochondria-lysosome contacts by GBA1 dysfunction in dopaminergic neuronal models of Parkinson’s disease

Documents similaires