Polyglutamine aggregate structure in vitro and in vivo; new avenues for coherent anti-Stokes Raman scattering microscopy.

Coherent anti-Stokes Raman scattering (CARS) microscopy is applied for the first time for the evaluation of the protein secondary structure of polyglutamine (polyQ) aggregates in vivo. Our approach demonstrates the potential for translating information about protein structure that has been obtained...

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Bibliographic Details
Main Authors: Nicolas M Perney, Lucy Braddick, Martin Jurna, Erik T Garbacik, Herman L Offerhaus, Louise C Serpell, Ewan Blanch, Lindy Holden-Dye, William S Brocklesby, Tracy Melvin
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2012
Subjects:
R
Q
Online Access:https://doaj.org/article/40a13d122b3f455198783d7ec15c2161
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