ANGPTL4 deficiency in haematopoietic cells promotes monocyte expansion and atherosclerosis progression

Angiopoietin-like 4 protein (ANGPTL4) is a regulator of lipoprotein metabolism whose role in atherosclerosis has been controversial. Here the authors show that ANGPTL4 deficiency in haematopoietic cells increases atherogenesis by promoting myeloid progenitor cell expansion and differentiation, foam...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Binod Aryal, Noemi Rotllan, Elisa Araldi, Cristina M. Ramírez, Shun He, Benjamin G. Chousterman, Ashley M. Fenn, Amarylis Wanschel, Julio Madrigal-Matute, Nikhil Warrier, Jose L. Martín-Ventura, Filip K. Swirski, Yajaira Suárez, Carlos Fernández-Hernando
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/40a361abcb9741eda09eb9b03b905155
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:40a361abcb9741eda09eb9b03b905155
record_format	dspace
spelling	oai:doaj.org-article:40a361abcb9741eda09eb9b03b9051552021-12-02T16:56:45ZANGPTL4 deficiency in haematopoietic cells promotes monocyte expansion and atherosclerosis progression10.1038/ncomms123132041-1723https://doaj.org/article/40a361abcb9741eda09eb9b03b9051552016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12313https://doaj.org/toc/2041-1723Angiopoietin-like 4 protein (ANGPTL4) is a regulator of lipoprotein metabolism whose role in atherosclerosis has been controversial. Here the authors show that ANGPTL4 deficiency in haematopoietic cells increases atherogenesis by promoting myeloid progenitor cell expansion and differentiation, foam cell formation and vascular inflammation.Binod AryalNoemi RotllanElisa AraldiCristina M. RamírezShun HeBenjamin G. ChoustermanAshley M. FennAmarylis WanschelJulio Madrigal-MatuteNikhil WarrierJose L. Martín-VenturaFilip K. SwirskiYajaira SuárezCarlos Fernández-HernandoNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Binod Aryal Noemi Rotllan Elisa Araldi Cristina M. Ramírez Shun He Benjamin G. Chousterman Ashley M. Fenn Amarylis Wanschel Julio Madrigal-Matute Nikhil Warrier Jose L. Martín-Ventura Filip K. Swirski Yajaira Suárez Carlos Fernández-Hernando ANGPTL4 deficiency in haematopoietic cells promotes monocyte expansion and atherosclerosis progression
description	Angiopoietin-like 4 protein (ANGPTL4) is a regulator of lipoprotein metabolism whose role in atherosclerosis has been controversial. Here the authors show that ANGPTL4 deficiency in haematopoietic cells increases atherogenesis by promoting myeloid progenitor cell expansion and differentiation, foam cell formation and vascular inflammation.
format	article
author	Binod Aryal Noemi Rotllan Elisa Araldi Cristina M. Ramírez Shun He Benjamin G. Chousterman Ashley M. Fenn Amarylis Wanschel Julio Madrigal-Matute Nikhil Warrier Jose L. Martín-Ventura Filip K. Swirski Yajaira Suárez Carlos Fernández-Hernando
author_facet	Binod Aryal Noemi Rotllan Elisa Araldi Cristina M. Ramírez Shun He Benjamin G. Chousterman Ashley M. Fenn Amarylis Wanschel Julio Madrigal-Matute Nikhil Warrier Jose L. Martín-Ventura Filip K. Swirski Yajaira Suárez Carlos Fernández-Hernando
author_sort	Binod Aryal
title	ANGPTL4 deficiency in haematopoietic cells promotes monocyte expansion and atherosclerosis progression
title_short	ANGPTL4 deficiency in haematopoietic cells promotes monocyte expansion and atherosclerosis progression
title_full	ANGPTL4 deficiency in haematopoietic cells promotes monocyte expansion and atherosclerosis progression
title_fullStr	ANGPTL4 deficiency in haematopoietic cells promotes monocyte expansion and atherosclerosis progression
title_full_unstemmed	ANGPTL4 deficiency in haematopoietic cells promotes monocyte expansion and atherosclerosis progression
title_sort	angptl4 deficiency in haematopoietic cells promotes monocyte expansion and atherosclerosis progression
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/40a361abcb9741eda09eb9b03b905155
work_keys_str_mv	AT binodaryal angptl4deficiencyinhaematopoieticcellspromotesmonocyteexpansionandatherosclerosisprogression AT noemirotllan angptl4deficiencyinhaematopoieticcellspromotesmonocyteexpansionandatherosclerosisprogression AT elisaaraldi angptl4deficiencyinhaematopoieticcellspromotesmonocyteexpansionandatherosclerosisprogression AT cristinamramirez angptl4deficiencyinhaematopoieticcellspromotesmonocyteexpansionandatherosclerosisprogression AT shunhe angptl4deficiencyinhaematopoieticcellspromotesmonocyteexpansionandatherosclerosisprogression AT benjamingchousterman angptl4deficiencyinhaematopoieticcellspromotesmonocyteexpansionandatherosclerosisprogression AT ashleymfenn angptl4deficiencyinhaematopoieticcellspromotesmonocyteexpansionandatherosclerosisprogression AT amaryliswanschel angptl4deficiencyinhaematopoieticcellspromotesmonocyteexpansionandatherosclerosisprogression AT juliomadrigalmatute angptl4deficiencyinhaematopoieticcellspromotesmonocyteexpansionandatherosclerosisprogression AT nikhilwarrier angptl4deficiencyinhaematopoieticcellspromotesmonocyteexpansionandatherosclerosisprogression AT joselmartinventura angptl4deficiencyinhaematopoieticcellspromotesmonocyteexpansionandatherosclerosisprogression AT filipkswirski angptl4deficiencyinhaematopoieticcellspromotesmonocyteexpansionandatherosclerosisprogression AT yajairasuarez angptl4deficiencyinhaematopoieticcellspromotesmonocyteexpansionandatherosclerosisprogression AT carlosfernandezhernando angptl4deficiencyinhaematopoieticcellspromotesmonocyteexpansionandatherosclerosisprogression
_version_	1718382735442051072

ANGPTL4 deficiency in haematopoietic cells promotes monocyte expansion and atherosclerosis progression

Ejemplares similares