Systematic identification of metabolites controlling gene expression in E. coli

Interactions between metabolites and transcription factors are known to control gene expression but analyzing these events at genome-scale is challenging. Here, the authors integrate dynamic metabolome and transcriptome data from E.coli to predict regulatory metabolite-transcription factor interacti...

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Auteurs principaux: Martin Lempp, Niklas Farke, Michelle Kuntz, Sven Andreas Freibert, Roland Lill, Hannes Link
Format: article
Langue:EN
Publié: Nature Portfolio 2019
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Accès en ligne:https://doaj.org/article/40a4273f4f2f49d69ac21e2945fcb595
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Résumé:Interactions between metabolites and transcription factors are known to control gene expression but analyzing these events at genome-scale is challenging. Here, the authors integrate dynamic metabolome and transcriptome data from E.coli to predict regulatory metabolite-transcription factor interactions.