Systematic identification of metabolites controlling gene expression in E. coli

Interactions between metabolites and transcription factors are known to control gene expression but analyzing these events at genome-scale is challenging. Here, the authors integrate dynamic metabolome and transcriptome data from E.coli to predict regulatory metabolite-transcription factor interacti...

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Auteurs principaux:	Martin Lempp, Niklas Farke, Michelle Kuntz, Sven Andreas Freibert, Roland Lill, Hannes Link
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2019
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/40a4273f4f2f49d69ac21e2945fcb595
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spelling	oai:doaj.org-article:40a4273f4f2f49d69ac21e2945fcb5952021-12-02T16:57:41ZSystematic identification of metabolites controlling gene expression in E. coli10.1038/s41467-019-12474-12041-1723https://doaj.org/article/40a4273f4f2f49d69ac21e2945fcb5952019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12474-1https://doaj.org/toc/2041-1723Interactions between metabolites and transcription factors are known to control gene expression but analyzing these events at genome-scale is challenging. Here, the authors integrate dynamic metabolome and transcriptome data from E.coli to predict regulatory metabolite-transcription factor interactions.Martin LemppNiklas FarkeMichelle KuntzSven Andreas FreibertRoland LillHannes LinkNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Martin Lempp Niklas Farke Michelle Kuntz Sven Andreas Freibert Roland Lill Hannes Link Systematic identification of metabolites controlling gene expression in E. coli
description	Interactions between metabolites and transcription factors are known to control gene expression but analyzing these events at genome-scale is challenging. Here, the authors integrate dynamic metabolome and transcriptome data from E.coli to predict regulatory metabolite-transcription factor interactions.
format	article
author	Martin Lempp Niklas Farke Michelle Kuntz Sven Andreas Freibert Roland Lill Hannes Link
author_facet	Martin Lempp Niklas Farke Michelle Kuntz Sven Andreas Freibert Roland Lill Hannes Link
author_sort	Martin Lempp
title	Systematic identification of metabolites controlling gene expression in E. coli
title_short	Systematic identification of metabolites controlling gene expression in E. coli
title_full	Systematic identification of metabolites controlling gene expression in E. coli
title_fullStr	Systematic identification of metabolites controlling gene expression in E. coli
title_full_unstemmed	Systematic identification of metabolites controlling gene expression in E. coli
title_sort	systematic identification of metabolites controlling gene expression in e. coli
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/40a4273f4f2f49d69ac21e2945fcb595
work_keys_str_mv	AT martinlempp systematicidentificationofmetabolitescontrollinggeneexpressioninecoli AT niklasfarke systematicidentificationofmetabolitescontrollinggeneexpressioninecoli AT michellekuntz systematicidentificationofmetabolitescontrollinggeneexpressioninecoli AT svenandreasfreibert systematicidentificationofmetabolitescontrollinggeneexpressioninecoli AT rolandlill systematicidentificationofmetabolitescontrollinggeneexpressioninecoli AT hanneslink systematicidentificationofmetabolitescontrollinggeneexpressioninecoli
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Systematic identification of metabolites controlling gene expression in E. coli

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