RNA is a critical element for the sizing and the composition of phase-separated RNA–protein condensates

RNA promotes liquid-liquid phase separation and contributes to the ribonucleoprotein granule assembly. Here the authors employ the protein scaffold ArtiGranule and show the role of intracellular RNA in nucleation and sizing of the phase separated condensates.

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Detalles Bibliográficos
Autores principales: Marina Garcia-Jove Navarro, Shunnichi Kashida, Racha Chouaib, Sylvie Souquere, Gérard Pierron, Dominique Weil, Zoher Gueroui
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/40a67bdf05fb4718a204bdddd64f38ad
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Sumario:RNA promotes liquid-liquid phase separation and contributes to the ribonucleoprotein granule assembly. Here the authors employ the protein scaffold ArtiGranule and show the role of intracellular RNA in nucleation and sizing of the phase separated condensates.