Mitochondrial Uncoupling Proteins (UCPs) as Key Modulators of ROS Homeostasis: A Crosstalk between Diabesity and Male Infertility?

Uncoupling proteins (UCPs) are transmembrane proteins members of the mitochondrial anion transporter family present in the mitochondrial inner membrane. Currently, six homologs have been identified (UCP1-6) in mammals, with ubiquitous tissue distribution and multiple physiological functions. UCPs ar...

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Autores principales:	Bruno S. Monteiro, Laís Freire-Brito, David F. Carrageta, Pedro F. Oliveira, Marco G. Alves
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	diabetes mellitus male infertility mitochondrial bioenergetics obesity oxidative stress ROS production Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/40a8f872b4b64e04abf27b874d964fe5
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spelling	oai:doaj.org-article:40a8f872b4b64e04abf27b874d964fe52021-11-25T16:27:43ZMitochondrial Uncoupling Proteins (UCPs) as Key Modulators of ROS Homeostasis: A Crosstalk between Diabesity and Male Infertility?10.3390/antiox101117462076-3921https://doaj.org/article/40a8f872b4b64e04abf27b874d964fe52021-10-01T00:00:00Zhttps://www.mdpi.com/2076-3921/10/11/1746https://doaj.org/toc/2076-3921Uncoupling proteins (UCPs) are transmembrane proteins members of the mitochondrial anion transporter family present in the mitochondrial inner membrane. Currently, six homologs have been identified (UCP1-6) in mammals, with ubiquitous tissue distribution and multiple physiological functions. UCPs are regulators of key events for cellular bioenergetic metabolism, such as membrane potential, metabolic efficiency, and energy dissipation also functioning as pivotal modulators of ROS production and general cellular redox state. UCPs can act as proton channels, leading to proton re-entry the mitochondrial matrix from the intermembrane space and thus collapsing the proton gradient and decreasing the membrane potential. Each homolog exhibits its specific functions, from thermogenesis to regulation of ROS production. The expression and function of UCPs are intimately linked to diabesity, with their dysregulation/dysfunction not only associated to diabesity onset, but also by exacerbating oxidative stress-related damage. Male infertility is one of the most overlooked diabesity-related comorbidities, where high oxidative stress takes a major role. In this review, we discuss in detail the expression and function of the different UCP homologs. In addition, the role of UCPs as key regulators of ROS production and redox homeostasis, as well as their influence on the pathophysiology of diabesity and potential role on diabesity-induced male infertility is debated.Bruno S. MonteiroLaís Freire-BritoDavid F. CarragetaPedro F. OliveiraMarco G. AlvesMDPI AGarticlediabetes mellitusmale infertilitymitochondrial bioenergeticsobesityoxidative stressROS productionTherapeutics. PharmacologyRM1-950ENAntioxidants, Vol 10, Iss 1746, p 1746 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetes mellitus male infertility mitochondrial bioenergetics obesity oxidative stress ROS production Therapeutics. Pharmacology RM1-950
spellingShingle	diabetes mellitus male infertility mitochondrial bioenergetics obesity oxidative stress ROS production Therapeutics. Pharmacology RM1-950 Bruno S. Monteiro Laís Freire-Brito David F. Carrageta Pedro F. Oliveira Marco G. Alves Mitochondrial Uncoupling Proteins (UCPs) as Key Modulators of ROS Homeostasis: A Crosstalk between Diabesity and Male Infertility?
description	Uncoupling proteins (UCPs) are transmembrane proteins members of the mitochondrial anion transporter family present in the mitochondrial inner membrane. Currently, six homologs have been identified (UCP1-6) in mammals, with ubiquitous tissue distribution and multiple physiological functions. UCPs are regulators of key events for cellular bioenergetic metabolism, such as membrane potential, metabolic efficiency, and energy dissipation also functioning as pivotal modulators of ROS production and general cellular redox state. UCPs can act as proton channels, leading to proton re-entry the mitochondrial matrix from the intermembrane space and thus collapsing the proton gradient and decreasing the membrane potential. Each homolog exhibits its specific functions, from thermogenesis to regulation of ROS production. The expression and function of UCPs are intimately linked to diabesity, with their dysregulation/dysfunction not only associated to diabesity onset, but also by exacerbating oxidative stress-related damage. Male infertility is one of the most overlooked diabesity-related comorbidities, where high oxidative stress takes a major role. In this review, we discuss in detail the expression and function of the different UCP homologs. In addition, the role of UCPs as key regulators of ROS production and redox homeostasis, as well as their influence on the pathophysiology of diabesity and potential role on diabesity-induced male infertility is debated.
format	article
author	Bruno S. Monteiro Laís Freire-Brito David F. Carrageta Pedro F. Oliveira Marco G. Alves
author_facet	Bruno S. Monteiro Laís Freire-Brito David F. Carrageta Pedro F. Oliveira Marco G. Alves
author_sort	Bruno S. Monteiro
title	Mitochondrial Uncoupling Proteins (UCPs) as Key Modulators of ROS Homeostasis: A Crosstalk between Diabesity and Male Infertility?
title_short	Mitochondrial Uncoupling Proteins (UCPs) as Key Modulators of ROS Homeostasis: A Crosstalk between Diabesity and Male Infertility?
title_full	Mitochondrial Uncoupling Proteins (UCPs) as Key Modulators of ROS Homeostasis: A Crosstalk between Diabesity and Male Infertility?
title_fullStr	Mitochondrial Uncoupling Proteins (UCPs) as Key Modulators of ROS Homeostasis: A Crosstalk between Diabesity and Male Infertility?
title_full_unstemmed	Mitochondrial Uncoupling Proteins (UCPs) as Key Modulators of ROS Homeostasis: A Crosstalk between Diabesity and Male Infertility?
title_sort	mitochondrial uncoupling proteins (ucps) as key modulators of ros homeostasis: a crosstalk between diabesity and male infertility?
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/40a8f872b4b64e04abf27b874d964fe5
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Mitochondrial Uncoupling Proteins (UCPs) as Key Modulators of ROS Homeostasis: A Crosstalk between Diabesity and Male Infertility?

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