The regulation of hyphae growth in Candida albicans

In the last decades, Candida albicans has served as the leading causal agent of life-threatening invasive infections with mortality rates approaching 40% despite treatment. Candida albicans (C. albicans) exists in three biological phases: yeast, pseudohyphae, and hyphae. Hyphae, which represent an i...

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Autores principales:	Hui Chen, Xuedong Zhou, Biao Ren, Lei Cheng
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2020
Materias:	oral candidiasis candida albicans hyphae mycelium fungi Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/40a90aa5d4334fbfb39708d714296f74
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id	oai:doaj.org-article:40a90aa5d4334fbfb39708d714296f74
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spelling	oai:doaj.org-article:40a90aa5d4334fbfb39708d714296f742021-11-17T14:21:58ZThe regulation of hyphae growth in Candida albicans2150-55942150-560810.1080/21505594.2020.1748930https://doaj.org/article/40a90aa5d4334fbfb39708d714296f742020-12-01T00:00:00Zhttp://dx.doi.org/10.1080/21505594.2020.1748930https://doaj.org/toc/2150-5594https://doaj.org/toc/2150-5608In the last decades, Candida albicans has served as the leading causal agent of life-threatening invasive infections with mortality rates approaching 40% despite treatment. Candida albicans (C. albicans) exists in three biological phases: yeast, pseudohyphae, and hyphae. Hyphae, which represent an important phase in the disease process, can cause tissue damage by invading mucosal epithelial cells then leading to blood infection. In this review, we summarized recent results from different ﬁelds of fungal cell biology that are instrumental in understanding hyphal growth. This includes research on the differences among C. albicans phases; the regulatory mechanism of hyphal growth, extension, and maintaining cutting-edge polarity; cross regulations of hyphal development and the virulence factors that cause serious infection. With a better understanding of the mechanism on mycelium formation, this review provides a theoretical basis for the identification of targets in candidiasis treatment. It also gives some reference to the study of antifungal drugs.Hui ChenXuedong ZhouBiao RenLei ChengTaylor & Francis Grouparticleoral candidiasiscandida albicanshyphaemyceliumfungiInfectious and parasitic diseasesRC109-216ENVirulence, Vol 11, Iss 1, Pp 337-348 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	oral candidiasis candida albicans hyphae mycelium fungi Infectious and parasitic diseases RC109-216
spellingShingle	oral candidiasis candida albicans hyphae mycelium fungi Infectious and parasitic diseases RC109-216 Hui Chen Xuedong Zhou Biao Ren Lei Cheng The regulation of hyphae growth in Candida albicans
description	In the last decades, Candida albicans has served as the leading causal agent of life-threatening invasive infections with mortality rates approaching 40% despite treatment. Candida albicans (C. albicans) exists in three biological phases: yeast, pseudohyphae, and hyphae. Hyphae, which represent an important phase in the disease process, can cause tissue damage by invading mucosal epithelial cells then leading to blood infection. In this review, we summarized recent results from different ﬁelds of fungal cell biology that are instrumental in understanding hyphal growth. This includes research on the differences among C. albicans phases; the regulatory mechanism of hyphal growth, extension, and maintaining cutting-edge polarity; cross regulations of hyphal development and the virulence factors that cause serious infection. With a better understanding of the mechanism on mycelium formation, this review provides a theoretical basis for the identification of targets in candidiasis treatment. It also gives some reference to the study of antifungal drugs.
format	article
author	Hui Chen Xuedong Zhou Biao Ren Lei Cheng
author_facet	Hui Chen Xuedong Zhou Biao Ren Lei Cheng
author_sort	Hui Chen
title	The regulation of hyphae growth in Candida albicans
title_short	The regulation of hyphae growth in Candida albicans
title_full	The regulation of hyphae growth in Candida albicans
title_fullStr	The regulation of hyphae growth in Candida albicans
title_full_unstemmed	The regulation of hyphae growth in Candida albicans
title_sort	regulation of hyphae growth in candida albicans
publisher	Taylor & Francis Group
publishDate	2020
url	https://doaj.org/article/40a90aa5d4334fbfb39708d714296f74
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The regulation of hyphae growth in Candida albicans

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