Metabolic Reprogramming and Renal Fibrosis

There are several causes of chronic kidney disease, but all of these patients have renal fibrosis. Although many studies have examined the pathogenesis of renal fibrosis, there are still no effective treatments. A healthy and balanced metabolism is necessary for normal cell growth, proliferation, an...

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Autores principales:	Xiaoyu Zhu, Lili Jiang, Mengtuan Long, Xuejiao Wei, Yue Hou, Yujun Du
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	renal fibrosis chronic kidney disease metabolic reprogramming fatty acid aerobic glycolysis Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/40ac0209e09a45a1b591bd64b0f3a992
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id	oai:doaj.org-article:40ac0209e09a45a1b591bd64b0f3a992
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spelling	oai:doaj.org-article:40ac0209e09a45a1b591bd64b0f3a9922021-11-08T08:02:44ZMetabolic Reprogramming and Renal Fibrosis2296-858X10.3389/fmed.2021.746920https://doaj.org/article/40ac0209e09a45a1b591bd64b0f3a9922021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.746920/fullhttps://doaj.org/toc/2296-858XThere are several causes of chronic kidney disease, but all of these patients have renal fibrosis. Although many studies have examined the pathogenesis of renal fibrosis, there are still no effective treatments. A healthy and balanced metabolism is necessary for normal cell growth, proliferation, and function, but metabolic abnormalities can lead to pathological changes. Normal energy metabolism is particularly important for maintaining the structure and function of the kidneys because they consume large amounts of energy. We describe the metabolic reprogramming that occurs during renal fibrosis, which includes changes in fatty acid metabolism and glucose metabolism, and the relationship of these changes with renal fibrosis. We also describe the potential role of novel drugs that disrupt this metabolic reprogramming and the development of fibrosis, and current and future challenges in the treatment of fibrosis.Xiaoyu ZhuLili JiangMengtuan LongXuejiao WeiYue HouYujun DuFrontiers Media S.A.articlerenal fibrosischronic kidney diseasemetabolic reprogrammingfatty acidaerobic glycolysisMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	renal fibrosis chronic kidney disease metabolic reprogramming fatty acid aerobic glycolysis Medicine (General) R5-920
spellingShingle	renal fibrosis chronic kidney disease metabolic reprogramming fatty acid aerobic glycolysis Medicine (General) R5-920 Xiaoyu Zhu Lili Jiang Mengtuan Long Xuejiao Wei Yue Hou Yujun Du Metabolic Reprogramming and Renal Fibrosis
description	There are several causes of chronic kidney disease, but all of these patients have renal fibrosis. Although many studies have examined the pathogenesis of renal fibrosis, there are still no effective treatments. A healthy and balanced metabolism is necessary for normal cell growth, proliferation, and function, but metabolic abnormalities can lead to pathological changes. Normal energy metabolism is particularly important for maintaining the structure and function of the kidneys because they consume large amounts of energy. We describe the metabolic reprogramming that occurs during renal fibrosis, which includes changes in fatty acid metabolism and glucose metabolism, and the relationship of these changes with renal fibrosis. We also describe the potential role of novel drugs that disrupt this metabolic reprogramming and the development of fibrosis, and current and future challenges in the treatment of fibrosis.
format	article
author	Xiaoyu Zhu Lili Jiang Mengtuan Long Xuejiao Wei Yue Hou Yujun Du
author_facet	Xiaoyu Zhu Lili Jiang Mengtuan Long Xuejiao Wei Yue Hou Yujun Du
author_sort	Xiaoyu Zhu
title	Metabolic Reprogramming and Renal Fibrosis
title_short	Metabolic Reprogramming and Renal Fibrosis
title_full	Metabolic Reprogramming and Renal Fibrosis
title_fullStr	Metabolic Reprogramming and Renal Fibrosis
title_full_unstemmed	Metabolic Reprogramming and Renal Fibrosis
title_sort	metabolic reprogramming and renal fibrosis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/40ac0209e09a45a1b591bd64b0f3a992
work_keys_str_mv	AT xiaoyuzhu metabolicreprogrammingandrenalfibrosis AT lilijiang metabolicreprogrammingandrenalfibrosis AT mengtuanlong metabolicreprogrammingandrenalfibrosis AT xuejiaowei metabolicreprogrammingandrenalfibrosis AT yuehou metabolicreprogrammingandrenalfibrosis AT yujundu metabolicreprogrammingandrenalfibrosis
_version_	1718442799543615488

Metabolic Reprogramming and Renal Fibrosis

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