Purkinje cells located in the adult zebrafish valvula cerebelli exhibit variable functional responses

Abstract Purkinje cells are critically involved in processing the cerebellar functions by shaping and coordinating commands that they receive. Here, we demonstrate experimentally that in the adult zebrafish valvular part of the cerebellum, the Purkinje cells exhibited variable firing and functional...

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Autores principales:	Weipang Chang, Andrea Pedroni, Reinhard W. Köster, Stefania Giacomello, Konstantinos Ampatzis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/40ae9461efb646e9bb8852178b005b29
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spelling	oai:doaj.org-article:40ae9461efb646e9bb8852178b005b292021-12-02T17:24:02ZPurkinje cells located in the adult zebrafish valvula cerebelli exhibit variable functional responses10.1038/s41598-021-98035-32045-2322https://doaj.org/article/40ae9461efb646e9bb8852178b005b292021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98035-3https://doaj.org/toc/2045-2322Abstract Purkinje cells are critically involved in processing the cerebellar functions by shaping and coordinating commands that they receive. Here, we demonstrate experimentally that in the adult zebrafish valvular part of the cerebellum, the Purkinje cells exhibited variable firing and functional responses and allowed the categorization into three firing classes. Compared with the Purkinje cells in the corpus cerebelli, the valvular Purkinje cells receive weak and occasional input from the inferior olive and are not active during locomotion. Together, our findings expand further the regional functional differences of the Purkinje cell population and expose their non-locomotor functionality.Weipang ChangAndrea PedroniReinhard W. KösterStefania GiacomelloKonstantinos AmpatzisNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Weipang Chang Andrea Pedroni Reinhard W. Köster Stefania Giacomello Konstantinos Ampatzis Purkinje cells located in the adult zebrafish valvula cerebelli exhibit variable functional responses
description	Abstract Purkinje cells are critically involved in processing the cerebellar functions by shaping and coordinating commands that they receive. Here, we demonstrate experimentally that in the adult zebrafish valvular part of the cerebellum, the Purkinje cells exhibited variable firing and functional responses and allowed the categorization into three firing classes. Compared with the Purkinje cells in the corpus cerebelli, the valvular Purkinje cells receive weak and occasional input from the inferior olive and are not active during locomotion. Together, our findings expand further the regional functional differences of the Purkinje cell population and expose their non-locomotor functionality.
format	article
author	Weipang Chang Andrea Pedroni Reinhard W. Köster Stefania Giacomello Konstantinos Ampatzis
author_facet	Weipang Chang Andrea Pedroni Reinhard W. Köster Stefania Giacomello Konstantinos Ampatzis
author_sort	Weipang Chang
title	Purkinje cells located in the adult zebrafish valvula cerebelli exhibit variable functional responses
title_short	Purkinje cells located in the adult zebrafish valvula cerebelli exhibit variable functional responses
title_full	Purkinje cells located in the adult zebrafish valvula cerebelli exhibit variable functional responses
title_fullStr	Purkinje cells located in the adult zebrafish valvula cerebelli exhibit variable functional responses
title_full_unstemmed	Purkinje cells located in the adult zebrafish valvula cerebelli exhibit variable functional responses
title_sort	purkinje cells located in the adult zebrafish valvula cerebelli exhibit variable functional responses
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/40ae9461efb646e9bb8852178b005b29
work_keys_str_mv	AT weipangchang purkinjecellslocatedintheadultzebrafishvalvulacerebelliexhibitvariablefunctionalresponses AT andreapedroni purkinjecellslocatedintheadultzebrafishvalvulacerebelliexhibitvariablefunctionalresponses AT reinhardwkoster purkinjecellslocatedintheadultzebrafishvalvulacerebelliexhibitvariablefunctionalresponses AT stefaniagiacomello purkinjecellslocatedintheadultzebrafishvalvulacerebelliexhibitvariablefunctionalresponses AT konstantinosampatzis purkinjecellslocatedintheadultzebrafishvalvulacerebelliexhibitvariablefunctionalresponses
_version_	1718380962808594432

Purkinje cells located in the adult zebrafish valvula cerebelli exhibit variable functional responses

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