Lysophosphatidic acid activates peroxisome proliferator activated receptor-γ in CHO cells that over-express glycerol 3-phosphate acyltransferase-1.

Lysophosphatidic acid activates peroxisome proliferator activated receptor-γ in CHO cells that over-express glycerol 3-phosphate acyltransferase-1.

Lysophosphatidic acid (LPA) is an agonist for peroxisome proliferator activated receptor-γ (PPARγ). Although glycerol-3-phosphate acyltransferase-1 (GPAT1) esterifies glycerol-3-phosphate to form LPA, an intermediate in the de novo synthesis of glycerolipids, it has been assumed that LPA synthesized...

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Bibliographic Details
Main Authors: Cliona M Stapleton, Douglas G Mashek, Shuli Wang, Cynthia A Nagle, Gary W Cline, Philippe Thuillier, Lisa M Leesnitzer, Lei O Li, Julie B Stimmel, Gerald I Shulman, Rosalind A Coleman
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2011
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/40afaff6753f40df85ff7c48255f8fe7
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