Impaired memory B-cell recall responses in the elderly following recurrent influenza vaccination.

Influenza is a highly contagious viral respiratory disease that affects million of people worldwide each year. Annual vaccination is recommended by the World Health Organization with the goal of reducing influenza severity and limiting transmission through elicitation of antibodies targeting the hem...

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Autores principales:	Rodrigo B Abreu, Greg A Kirchenbaum, Giuseppe A Sautto, Emily F Clutter, Ted M Ross
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/40b362f1ca4745a381b875e956033aea
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spelling	oai:doaj.org-article:40b362f1ca4745a381b875e956033aea2021-12-02T20:18:42ZImpaired memory B-cell recall responses in the elderly following recurrent influenza vaccination.1932-620310.1371/journal.pone.0254421https://doaj.org/article/40b362f1ca4745a381b875e956033aea2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0254421https://doaj.org/toc/1932-6203Influenza is a highly contagious viral respiratory disease that affects million of people worldwide each year. Annual vaccination is recommended by the World Health Organization with the goal of reducing influenza severity and limiting transmission through elicitation of antibodies targeting the hemagglutinin (HA) glycoprotein. The antibody response elicited by current seasonal influenza virus vaccines is predominantly strain-specific, but pre-existing influenza virus immunity can greatly impact the serological antibody response to vaccination. However, it remains unclear how B cell memory is shaped by recurrent annual vaccination over the course of multiple seasons, especially in high-risk elderly populations. Here, we systematically profiled the B cell response in young adult (18-34 year old) and elderly (65+ year old) vaccine recipients that received annual split inactivated influenza virus vaccination for 3 consecutive seasons. Specifically, the antibody serological and memory B-cell compartments were profiled for reactivity against current and historical influenza A virus strains. Moreover, multiparametric analysis and antibody landscape profiling revealed a transient increase in strain-specific antibodies in the elderly, but with an impaired recall response of pre-existing memory B-cells, plasmablast (PB) differentiation and long-lasting serological changes. This study thoroughly profiles and compares the immune response to recurrent influenza virus vaccination in young and elderly participants unveiling the pitfalls of current influenza virus vaccines in high-risk populations.Rodrigo B AbreuGreg A KirchenbaumGiuseppe A SauttoEmily F ClutterTed M RossPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0254421 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rodrigo B Abreu Greg A Kirchenbaum Giuseppe A Sautto Emily F Clutter Ted M Ross Impaired memory B-cell recall responses in the elderly following recurrent influenza vaccination.
description	Influenza is a highly contagious viral respiratory disease that affects million of people worldwide each year. Annual vaccination is recommended by the World Health Organization with the goal of reducing influenza severity and limiting transmission through elicitation of antibodies targeting the hemagglutinin (HA) glycoprotein. The antibody response elicited by current seasonal influenza virus vaccines is predominantly strain-specific, but pre-existing influenza virus immunity can greatly impact the serological antibody response to vaccination. However, it remains unclear how B cell memory is shaped by recurrent annual vaccination over the course of multiple seasons, especially in high-risk elderly populations. Here, we systematically profiled the B cell response in young adult (18-34 year old) and elderly (65+ year old) vaccine recipients that received annual split inactivated influenza virus vaccination for 3 consecutive seasons. Specifically, the antibody serological and memory B-cell compartments were profiled for reactivity against current and historical influenza A virus strains. Moreover, multiparametric analysis and antibody landscape profiling revealed a transient increase in strain-specific antibodies in the elderly, but with an impaired recall response of pre-existing memory B-cells, plasmablast (PB) differentiation and long-lasting serological changes. This study thoroughly profiles and compares the immune response to recurrent influenza virus vaccination in young and elderly participants unveiling the pitfalls of current influenza virus vaccines in high-risk populations.
format	article
author	Rodrigo B Abreu Greg A Kirchenbaum Giuseppe A Sautto Emily F Clutter Ted M Ross
author_facet	Rodrigo B Abreu Greg A Kirchenbaum Giuseppe A Sautto Emily F Clutter Ted M Ross
author_sort	Rodrigo B Abreu
title	Impaired memory B-cell recall responses in the elderly following recurrent influenza vaccination.
title_short	Impaired memory B-cell recall responses in the elderly following recurrent influenza vaccination.
title_full	Impaired memory B-cell recall responses in the elderly following recurrent influenza vaccination.
title_fullStr	Impaired memory B-cell recall responses in the elderly following recurrent influenza vaccination.
title_full_unstemmed	Impaired memory B-cell recall responses in the elderly following recurrent influenza vaccination.
title_sort	impaired memory b-cell recall responses in the elderly following recurrent influenza vaccination.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/40b362f1ca4745a381b875e956033aea
work_keys_str_mv	AT rodrigobabreu impairedmemorybcellrecallresponsesintheelderlyfollowingrecurrentinfluenzavaccination AT gregakirchenbaum impairedmemorybcellrecallresponsesintheelderlyfollowingrecurrentinfluenzavaccination AT giuseppeasautto impairedmemorybcellrecallresponsesintheelderlyfollowingrecurrentinfluenzavaccination AT emilyfclutter impairedmemorybcellrecallresponsesintheelderlyfollowingrecurrentinfluenzavaccination AT tedmross impairedmemorybcellrecallresponsesintheelderlyfollowingrecurrentinfluenzavaccination
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Impaired memory B-cell recall responses in the elderly following recurrent influenza vaccination.

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