Type-2 innate lymphoid cells control the development of atherosclerosis in mice

Type-2 innate lymphoid cells control the development of atherosclerosis in mice

Type-2 innate lymphoid cells (ILC2) affect adipose tissue metabolism and function. Here the authors show that the ILC2 are present in para-aortic adipose tissue and represent a major source of IL-5 and IL-13 required for mounting atheroprotective immunity, which can be altered by high fat diet.

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Detalles Bibliográficos
Autores principales: Stephen A. Newland, Sarajo Mohanta, Marc Clément, Soraya Taleb, Jennifer A. Walker, Meritxell Nus, Andrew P. Sage, Changjun Yin, Desheng Hu, Lauren L. Kitt, Alison J. Finigan, Hans-Reimer Rodewald, Christoph J. Binder, Andrew N. J. McKenzie, Andreas J. Habenicht, Ziad Mallat
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
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Acceso en línea:https://doaj.org/article/40b5f6eeef3343c8899a0bd9503d2198
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Descripción
Sumario:Type-2 innate lymphoid cells (ILC2) affect adipose tissue metabolism and function. Here the authors show that the ILC2 are present in para-aortic adipose tissue and represent a major source of IL-5 and IL-13 required for mounting atheroprotective immunity, which can be altered by high fat diet.

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