Alternative splicing controls teneurin-latrophilin interaction and synapse specificity by a shape-shifting mechanism

The trans-synaptic interaction of the cell-adhesion molecules teneurins (TENs) with latrophilins (LPHNs) promotes excitatory synapse formation. Here authors report the high resolution cryo-EM structure of the TEN2-LPHN3 complex, describe the trimeric TEN2-LPHN3-FLRT3 complex and show how alternative...

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Autores principales:	Jingxian Li, Yuan Xie, Shaleeka Cornelius, Xian Jiang, Richard Sando, Szymon P. Kordon, Man Pan, Katherine Leon, Thomas C. Südhof, Minglei Zhao, Demet Araç
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/40b62dc45fba43818c436bb498569426
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spelling	oai:doaj.org-article:40b62dc45fba43818c436bb4985694262021-12-02T15:39:22ZAlternative splicing controls teneurin-latrophilin interaction and synapse specificity by a shape-shifting mechanism10.1038/s41467-020-16029-72041-1723https://doaj.org/article/40b62dc45fba43818c436bb4985694262020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16029-7https://doaj.org/toc/2041-1723The trans-synaptic interaction of the cell-adhesion molecules teneurins (TENs) with latrophilins (LPHNs) promotes excitatory synapse formation. Here authors report the high resolution cryo-EM structure of the TEN2-LPHN3 complex, describe the trimeric TEN2-LPHN3-FLRT3 complex and show how alternative-splicing regulates the TEN2-LPHN3 interaction.Jingxian LiYuan XieShaleeka CorneliusXian JiangRichard SandoSzymon P. KordonMan PanKatherine LeonThomas C. SüdhofMinglei ZhaoDemet AraçNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jingxian Li Yuan Xie Shaleeka Cornelius Xian Jiang Richard Sando Szymon P. Kordon Man Pan Katherine Leon Thomas C. Südhof Minglei Zhao Demet Araç Alternative splicing controls teneurin-latrophilin interaction and synapse specificity by a shape-shifting mechanism
description	The trans-synaptic interaction of the cell-adhesion molecules teneurins (TENs) with latrophilins (LPHNs) promotes excitatory synapse formation. Here authors report the high resolution cryo-EM structure of the TEN2-LPHN3 complex, describe the trimeric TEN2-LPHN3-FLRT3 complex and show how alternative-splicing regulates the TEN2-LPHN3 interaction.
format	article
author	Jingxian Li Yuan Xie Shaleeka Cornelius Xian Jiang Richard Sando Szymon P. Kordon Man Pan Katherine Leon Thomas C. Südhof Minglei Zhao Demet Araç
author_facet	Jingxian Li Yuan Xie Shaleeka Cornelius Xian Jiang Richard Sando Szymon P. Kordon Man Pan Katherine Leon Thomas C. Südhof Minglei Zhao Demet Araç
author_sort	Jingxian Li
title	Alternative splicing controls teneurin-latrophilin interaction and synapse specificity by a shape-shifting mechanism
title_short	Alternative splicing controls teneurin-latrophilin interaction and synapse specificity by a shape-shifting mechanism
title_full	Alternative splicing controls teneurin-latrophilin interaction and synapse specificity by a shape-shifting mechanism
title_fullStr	Alternative splicing controls teneurin-latrophilin interaction and synapse specificity by a shape-shifting mechanism
title_full_unstemmed	Alternative splicing controls teneurin-latrophilin interaction and synapse specificity by a shape-shifting mechanism
title_sort	alternative splicing controls teneurin-latrophilin interaction and synapse specificity by a shape-shifting mechanism
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/40b62dc45fba43818c436bb498569426
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Alternative splicing controls teneurin-latrophilin interaction and synapse specificity by a shape-shifting mechanism

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