Alternative splicing controls teneurin-latrophilin interaction and synapse specificity by a shape-shifting mechanism
The trans-synaptic interaction of the cell-adhesion molecules teneurins (TENs) with latrophilins (LPHNs) promotes excitatory synapse formation. Here authors report the high resolution cryo-EM structure of the TEN2-LPHN3 complex, describe the trimeric TEN2-LPHN3-FLRT3 complex and show how alternative...
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Autores principales: | Jingxian Li, Yuan Xie, Shaleeka Cornelius, Xian Jiang, Richard Sando, Szymon P. Kordon, Man Pan, Katherine Leon, Thomas C. Südhof, Minglei Zhao, Demet Araç |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2020
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Materias: | |
Acceso en línea: | https://doaj.org/article/40b62dc45fba43818c436bb498569426 |
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