The LUCID study: living with ulcerative colitis; identifying the socioeconomic burden in Europe

Abstract Background Ulcerative colitis (UC) is an inflammatory bowel disease with increasing prevalence worldwide. Current treatment strategies place considerable economic and humanistic burdens on patients. The aim of this study was to determine the socioeconomic burden of UC in adult patients in E...

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Autores principales:	Leonardo Ruiz-Casas, Jonathan Evans, Alison Rose, Gabriel Ghizzi Pedra, Alan Lobo, Alan Finnegan, Bu Hayee, Laurent Peyrin-Biroulet, Andreas Sturm, Johan Burisch, Helen Terry, Luisa Avendano, Seb Tucknott, Gionata Fiorino, Jimmy Limdi
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Ulcerative colitis Health-related quality of life Socioeconomic burden Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/40b6e4deadbd48ecac7e78512e552441
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spelling	oai:doaj.org-article:40b6e4deadbd48ecac7e78512e5524412021-12-05T12:11:01ZThe LUCID study: living with ulcerative colitis; identifying the socioeconomic burden in Europe10.1186/s12876-021-02028-51471-230Xhttps://doaj.org/article/40b6e4deadbd48ecac7e78512e5524412021-12-01T00:00:00Zhttps://doi.org/10.1186/s12876-021-02028-5https://doaj.org/toc/1471-230XAbstract Background Ulcerative colitis (UC) is an inflammatory bowel disease with increasing prevalence worldwide. Current treatment strategies place considerable economic and humanistic burdens on patients. The aim of this study was to determine the socioeconomic burden of UC in adult patients in European countries in a real-world setting. Methods In this retrospective, cross-sectional and observational pan-European study, patients with moderate or severe UC were assigned to ARM 1 and patients who had moderate or severe UC but achieved mild or remission status 12 months before index date (or clinical consultation date), were assigned to ARM 2. Clinical and medical resource use data were collected via electronic case report forms, and data on non-medical and indirect costs, and health-related quality of life (HRQoL) were collected via patient and public involvement and engagement (PPIE) questionnaires. Per-patient annual total costs per ARM and per country were calculated using the collated resource use in the last 12 months (between the start of the documentation period and patient consultation or index date) and country specific unit costs. Quality of life was described by arm and by country. Results In the physician-reported eCRF population (n = 2966), the mean annual direct medical cost was €4065 in ARM 1 (n = 1835) and €2935 in ARM 2 (n = 1131). In the PPIE population (ARM 1, n = 1001; ARM 2, n = 647), mean annual direct cost was €4526 in ARM 1 and €3057 in ARM 2, mean annual direct non-medical cost was €1162 in ARM 1 and €1002 in ARM 2, mean annual indirect cost was €3098 in ARM 1 and €2309 ARM 2, and mean annual total cost was in €8787 in ARM 1 and €6368 in ARM 2. HRQoL scores showed moderate to high burden of UC in both groups. Conclusions The cost and HRQoL burden were high in patients in both ARM 1 and ARM 2 indicating unmet needs in the UC active population.Leonardo Ruiz-CasasJonathan EvansAlison RoseGabriel Ghizzi PedraAlan LoboAlan FinneganBu HayeeLaurent Peyrin-BirouletAndreas SturmJohan BurischHelen TerryLuisa AvendanoSeb TucknottGionata FiorinoJimmy LimdiBMCarticleUlcerative colitisHealth-related quality of lifeSocioeconomic burdenDiseases of the digestive system. GastroenterologyRC799-869ENBMC Gastroenterology, Vol 21, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ulcerative colitis Health-related quality of life Socioeconomic burden Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	Ulcerative colitis Health-related quality of life Socioeconomic burden Diseases of the digestive system. Gastroenterology RC799-869 Leonardo Ruiz-Casas Jonathan Evans Alison Rose Gabriel Ghizzi Pedra Alan Lobo Alan Finnegan Bu Hayee Laurent Peyrin-Biroulet Andreas Sturm Johan Burisch Helen Terry Luisa Avendano Seb Tucknott Gionata Fiorino Jimmy Limdi The LUCID study: living with ulcerative colitis; identifying the socioeconomic burden in Europe
description	Abstract Background Ulcerative colitis (UC) is an inflammatory bowel disease with increasing prevalence worldwide. Current treatment strategies place considerable economic and humanistic burdens on patients. The aim of this study was to determine the socioeconomic burden of UC in adult patients in European countries in a real-world setting. Methods In this retrospective, cross-sectional and observational pan-European study, patients with moderate or severe UC were assigned to ARM 1 and patients who had moderate or severe UC but achieved mild or remission status 12 months before index date (or clinical consultation date), were assigned to ARM 2. Clinical and medical resource use data were collected via electronic case report forms, and data on non-medical and indirect costs, and health-related quality of life (HRQoL) were collected via patient and public involvement and engagement (PPIE) questionnaires. Per-patient annual total costs per ARM and per country were calculated using the collated resource use in the last 12 months (between the start of the documentation period and patient consultation or index date) and country specific unit costs. Quality of life was described by arm and by country. Results In the physician-reported eCRF population (n = 2966), the mean annual direct medical cost was €4065 in ARM 1 (n = 1835) and €2935 in ARM 2 (n = 1131). In the PPIE population (ARM 1, n = 1001; ARM 2, n = 647), mean annual direct cost was €4526 in ARM 1 and €3057 in ARM 2, mean annual direct non-medical cost was €1162 in ARM 1 and €1002 in ARM 2, mean annual indirect cost was €3098 in ARM 1 and €2309 ARM 2, and mean annual total cost was in €8787 in ARM 1 and €6368 in ARM 2. HRQoL scores showed moderate to high burden of UC in both groups. Conclusions The cost and HRQoL burden were high in patients in both ARM 1 and ARM 2 indicating unmet needs in the UC active population.
format	article
author	Leonardo Ruiz-Casas Jonathan Evans Alison Rose Gabriel Ghizzi Pedra Alan Lobo Alan Finnegan Bu Hayee Laurent Peyrin-Biroulet Andreas Sturm Johan Burisch Helen Terry Luisa Avendano Seb Tucknott Gionata Fiorino Jimmy Limdi
author_facet	Leonardo Ruiz-Casas Jonathan Evans Alison Rose Gabriel Ghizzi Pedra Alan Lobo Alan Finnegan Bu Hayee Laurent Peyrin-Biroulet Andreas Sturm Johan Burisch Helen Terry Luisa Avendano Seb Tucknott Gionata Fiorino Jimmy Limdi
author_sort	Leonardo Ruiz-Casas
title	The LUCID study: living with ulcerative colitis; identifying the socioeconomic burden in Europe
title_short	The LUCID study: living with ulcerative colitis; identifying the socioeconomic burden in Europe
title_full	The LUCID study: living with ulcerative colitis; identifying the socioeconomic burden in Europe
title_fullStr	The LUCID study: living with ulcerative colitis; identifying the socioeconomic burden in Europe
title_full_unstemmed	The LUCID study: living with ulcerative colitis; identifying the socioeconomic burden in Europe
title_sort	lucid study: living with ulcerative colitis; identifying the socioeconomic burden in europe
publisher	BMC
publishDate	2021
url	https://doaj.org/article/40b6e4deadbd48ecac7e78512e552441
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The LUCID study: living with ulcerative colitis; identifying the socioeconomic burden in Europe

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