SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation
SARS-CoV-2 infection has been shown to drive NLRP3 inflammasome activation and thereby cytokine storm, but how it does so is unclear. Here the authors show that the viral N protein can bind to NLRP3, resulting in enhanced interaction with ASC and thereby with the NLRP3 inflammasome.
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Nature Portfolio
2021
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oai:doaj.org-article:40b9476cf93f4264a3303d60ead8698b2021-12-02T18:49:17ZSARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation10.1038/s41467-021-25015-62041-1723https://doaj.org/article/40b9476cf93f4264a3303d60ead8698b2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25015-6https://doaj.org/toc/2041-1723SARS-CoV-2 infection has been shown to drive NLRP3 inflammasome activation and thereby cytokine storm, but how it does so is unclear. Here the authors show that the viral N protein can bind to NLRP3, resulting in enhanced interaction with ASC and thereby with the NLRP3 inflammasome.Pan PanMiaomiao ShenZhenyang YuWeiwei GeKeli ChenMingfu TianFeng XiaoZhenwei WangJun WangYaling JiaWenbiao WangPin WanJing ZhangWeijie ChenZhiwei LeiXin ChenZhen LuoQiwei ZhangMeng XuGeng LiYongkui LiJianguo WuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Pan Pan Miaomiao Shen Zhenyang Yu Weiwei Ge Keli Chen Mingfu Tian Feng Xiao Zhenwei Wang Jun Wang Yaling Jia Wenbiao Wang Pin Wan Jing Zhang Weijie Chen Zhiwei Lei Xin Chen Zhen Luo Qiwei Zhang Meng Xu Geng Li Yongkui Li Jianguo Wu SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation |
| description |
SARS-CoV-2 infection has been shown to drive NLRP3 inflammasome activation and thereby cytokine storm, but how it does so is unclear. Here the authors show that the viral N protein can bind to NLRP3, resulting in enhanced interaction with ASC and thereby with the NLRP3 inflammasome. |
| format |
article |
| author |
Pan Pan Miaomiao Shen Zhenyang Yu Weiwei Ge Keli Chen Mingfu Tian Feng Xiao Zhenwei Wang Jun Wang Yaling Jia Wenbiao Wang Pin Wan Jing Zhang Weijie Chen Zhiwei Lei Xin Chen Zhen Luo Qiwei Zhang Meng Xu Geng Li Yongkui Li Jianguo Wu |
| author_facet |
Pan Pan Miaomiao Shen Zhenyang Yu Weiwei Ge Keli Chen Mingfu Tian Feng Xiao Zhenwei Wang Jun Wang Yaling Jia Wenbiao Wang Pin Wan Jing Zhang Weijie Chen Zhiwei Lei Xin Chen Zhen Luo Qiwei Zhang Meng Xu Geng Li Yongkui Li Jianguo Wu |
| author_sort |
Pan Pan |
| title |
SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation |
| title_short |
SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation |
| title_full |
SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation |
| title_fullStr |
SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation |
| title_full_unstemmed |
SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation |
| title_sort |
sars-cov-2 n protein promotes nlrp3 inflammasome activation to induce hyperinflammation |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/40b9476cf93f4264a3303d60ead8698b |
| work_keys_str_mv |
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| _version_ |
1718377556835565568 |