Co-morbidity between early-onset leukemia and type 1 diabetes--suggestive of a shared viral etiology?

<h4>Background</h4>Acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) are common early-onset malignancies. Their causes are largely unknown but infectious etiology has been implicated. Type 1 diabetes (T1D) is an autoimmune disease for which infectious triggers of diseas...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kari Hemminki, Richard Houlston, Jan Sundquist, Kristina Sundquist, Xiaochen Shu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/40b9a4f8ab7744f6b7d4cc6a9a6eea80
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:40b9a4f8ab7744f6b7d4cc6a9a6eea80
record_format	dspace
spelling	oai:doaj.org-article:40b9a4f8ab7744f6b7d4cc6a9a6eea802021-11-18T07:14:39ZCo-morbidity between early-onset leukemia and type 1 diabetes--suggestive of a shared viral etiology?1932-620310.1371/journal.pone.0039523https://doaj.org/article/40b9a4f8ab7744f6b7d4cc6a9a6eea802012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22745776/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) are common early-onset malignancies. Their causes are largely unknown but infectious etiology has been implicated. Type 1 diabetes (T1D) is an autoimmune disease for which infectious triggers of disease onset have been sought and increasing pointing to enteroviruses. Based on our previous results on co-morbidity between leukemia and T1D, we updated the Swedish dataset and focused on early onset leukemias in patients who had been hospitalized for T1D, comparing to those not hospitalized for T1D.<h4>Methods and findings</h4>Standardized incidence ratios (SIRs) were calculated for leukemia in 24,052 patients hospitalized for T1D covering years 1964 through 2008. T1D patients were included if hospitalized before age 21 years. Practically all Swedish children and adolescents with T1D are hospitalized at the start of insulin treatment. SIR for ALL was 8.30 (N = 18, 95% confidence interval 4.91-13.14) when diagnosed at age 10 to 20 years after hospitalization for T1D and it was 3.51 (13, 1.86-6.02) before hospitalization for T1D. The SIR for ALL was 19.85 (N = 33, 13.74-27.76) and that for AML was 25.28 (8, 10.80-50.06) when the leukemias were diagnosed within the year of T1D hospitalization. The SIRs increased to 38.97 (26, 25.43-57.18) and 40.11 (8, 17.13-79.42) when T1D was diagnosed between ages 10 to 20 years. No consistent time-dependent changes were found in leukemia risk.<h4>Conclusion</h4>A shared infectious etiology could be a plausible explanation to the observed co-morbidity. Other possible contributing factors could be insulin therapy or T1D related metabolic disturbances.Kari HemminkiRichard HoulstonJan SundquistKristina SundquistXiaochen ShuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 6, p e39523 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kari Hemminki Richard Houlston Jan Sundquist Kristina Sundquist Xiaochen Shu Co-morbidity between early-onset leukemia and type 1 diabetes--suggestive of a shared viral etiology?
description	<h4>Background</h4>Acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) are common early-onset malignancies. Their causes are largely unknown but infectious etiology has been implicated. Type 1 diabetes (T1D) is an autoimmune disease for which infectious triggers of disease onset have been sought and increasing pointing to enteroviruses. Based on our previous results on co-morbidity between leukemia and T1D, we updated the Swedish dataset and focused on early onset leukemias in patients who had been hospitalized for T1D, comparing to those not hospitalized for T1D.<h4>Methods and findings</h4>Standardized incidence ratios (SIRs) were calculated for leukemia in 24,052 patients hospitalized for T1D covering years 1964 through 2008. T1D patients were included if hospitalized before age 21 years. Practically all Swedish children and adolescents with T1D are hospitalized at the start of insulin treatment. SIR for ALL was 8.30 (N = 18, 95% confidence interval 4.91-13.14) when diagnosed at age 10 to 20 years after hospitalization for T1D and it was 3.51 (13, 1.86-6.02) before hospitalization for T1D. The SIR for ALL was 19.85 (N = 33, 13.74-27.76) and that for AML was 25.28 (8, 10.80-50.06) when the leukemias were diagnosed within the year of T1D hospitalization. The SIRs increased to 38.97 (26, 25.43-57.18) and 40.11 (8, 17.13-79.42) when T1D was diagnosed between ages 10 to 20 years. No consistent time-dependent changes were found in leukemia risk.<h4>Conclusion</h4>A shared infectious etiology could be a plausible explanation to the observed co-morbidity. Other possible contributing factors could be insulin therapy or T1D related metabolic disturbances.
format	article
author	Kari Hemminki Richard Houlston Jan Sundquist Kristina Sundquist Xiaochen Shu
author_facet	Kari Hemminki Richard Houlston Jan Sundquist Kristina Sundquist Xiaochen Shu
author_sort	Kari Hemminki
title	Co-morbidity between early-onset leukemia and type 1 diabetes--suggestive of a shared viral etiology?
title_short	Co-morbidity between early-onset leukemia and type 1 diabetes--suggestive of a shared viral etiology?
title_full	Co-morbidity between early-onset leukemia and type 1 diabetes--suggestive of a shared viral etiology?
title_fullStr	Co-morbidity between early-onset leukemia and type 1 diabetes--suggestive of a shared viral etiology?
title_full_unstemmed	Co-morbidity between early-onset leukemia and type 1 diabetes--suggestive of a shared viral etiology?
title_sort	co-morbidity between early-onset leukemia and type 1 diabetes--suggestive of a shared viral etiology?
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/40b9a4f8ab7744f6b7d4cc6a9a6eea80
work_keys_str_mv	AT karihemminki comorbiditybetweenearlyonsetleukemiaandtype1diabetessuggestiveofasharedviraletiology AT richardhoulston comorbiditybetweenearlyonsetleukemiaandtype1diabetessuggestiveofasharedviraletiology AT jansundquist comorbiditybetweenearlyonsetleukemiaandtype1diabetessuggestiveofasharedviraletiology AT kristinasundquist comorbiditybetweenearlyonsetleukemiaandtype1diabetessuggestiveofasharedviraletiology AT xiaochenshu comorbiditybetweenearlyonsetleukemiaandtype1diabetessuggestiveofasharedviraletiology
_version_	1718423720945516544

Co-morbidity between early-onset leukemia and type 1 diabetes--suggestive of a shared viral etiology?

Ejemplares similares