Early measurement of IL-10 predicts the outcomes of patients with acute respiratory distress syndrome receiving extracorporeal membrane oxygenation

Abstract Patients diagnosed with acute respiratory distress syndrome are generally severely distressed and associated with high morbidity and mortality despite aggressive treatments such as extracorporeal membrane oxygenation (ECMO) support. To identify potential biomarker of predicting value for ap...

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Autores principales:	Chia-Hsiung Liu, Shuenn-Wen Kuo, Wen-Je Ko, Pi-Ru Tsai, Shu-Wei Wu, Chien-Heng Lai, Chih-Hsien Wang, Yih-Sharng Chen, Pei-Lung Chen, Tze-Tze Liu, Shu-Chien Huang, Tzuu-Shuh Jou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/40baa0b602b9426091818e30e90cbeb1
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spelling	oai:doaj.org-article:40baa0b602b9426091818e30e90cbeb12021-12-02T15:05:51ZEarly measurement of IL-10 predicts the outcomes of patients with acute respiratory distress syndrome receiving extracorporeal membrane oxygenation10.1038/s41598-017-01225-12045-2322https://doaj.org/article/40baa0b602b9426091818e30e90cbeb12017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01225-1https://doaj.org/toc/2045-2322Abstract Patients diagnosed with acute respiratory distress syndrome are generally severely distressed and associated with high morbidity and mortality despite aggressive treatments such as extracorporeal membrane oxygenation (ECMO) support. To identify potential biomarker of predicting value for appropriate use of this intensive care resource, plasma interleukin-10 along with relevant inflammatory cytokines and immune cell populations were examined during the early and subsequent disease courses of 51 critically ill patients who received ECMO support. High interleukin-10 levels at the time of ECMO installation and during the first 6 hours after ECMO support of these patients stand as a promising biomarker associated with grave prognosis. The initial interleukin-10 level is correlated to other conventional risk evaluation scores as a predictive factor for survival, and furthermore, elevated interleukin-10 levels are also related to a delayed recovery of certain immune cell populations such as CD14+CD16+, CD14+TLR4+ monocytes, and T regulator cells. Genetically, high interleukin-10 is associated to two polymorphic nucleotides (−592 C and −819 C) at the interleukin-10 gene promoter area. Our finding provides prognostic and mechanistic information on the outcome of severely respiratory distressed patients, and potentially paves the strategy to develop new therapeutic modality based on the principles of precision medicine.Chia-Hsiung LiuShuenn-Wen KuoWen-Je KoPi-Ru TsaiShu-Wei WuChien-Heng LaiChih-Hsien WangYih-Sharng ChenPei-Lung ChenTze-Tze LiuShu-Chien HuangTzuu-Shuh JouNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chia-Hsiung Liu Shuenn-Wen Kuo Wen-Je Ko Pi-Ru Tsai Shu-Wei Wu Chien-Heng Lai Chih-Hsien Wang Yih-Sharng Chen Pei-Lung Chen Tze-Tze Liu Shu-Chien Huang Tzuu-Shuh Jou Early measurement of IL-10 predicts the outcomes of patients with acute respiratory distress syndrome receiving extracorporeal membrane oxygenation
description	Abstract Patients diagnosed with acute respiratory distress syndrome are generally severely distressed and associated with high morbidity and mortality despite aggressive treatments such as extracorporeal membrane oxygenation (ECMO) support. To identify potential biomarker of predicting value for appropriate use of this intensive care resource, plasma interleukin-10 along with relevant inflammatory cytokines and immune cell populations were examined during the early and subsequent disease courses of 51 critically ill patients who received ECMO support. High interleukin-10 levels at the time of ECMO installation and during the first 6 hours after ECMO support of these patients stand as a promising biomarker associated with grave prognosis. The initial interleukin-10 level is correlated to other conventional risk evaluation scores as a predictive factor for survival, and furthermore, elevated interleukin-10 levels are also related to a delayed recovery of certain immune cell populations such as CD14+CD16+, CD14+TLR4+ monocytes, and T regulator cells. Genetically, high interleukin-10 is associated to two polymorphic nucleotides (−592 C and −819 C) at the interleukin-10 gene promoter area. Our finding provides prognostic and mechanistic information on the outcome of severely respiratory distressed patients, and potentially paves the strategy to develop new therapeutic modality based on the principles of precision medicine.
format	article
author	Chia-Hsiung Liu Shuenn-Wen Kuo Wen-Je Ko Pi-Ru Tsai Shu-Wei Wu Chien-Heng Lai Chih-Hsien Wang Yih-Sharng Chen Pei-Lung Chen Tze-Tze Liu Shu-Chien Huang Tzuu-Shuh Jou
author_facet	Chia-Hsiung Liu Shuenn-Wen Kuo Wen-Je Ko Pi-Ru Tsai Shu-Wei Wu Chien-Heng Lai Chih-Hsien Wang Yih-Sharng Chen Pei-Lung Chen Tze-Tze Liu Shu-Chien Huang Tzuu-Shuh Jou
author_sort	Chia-Hsiung Liu
title	Early measurement of IL-10 predicts the outcomes of patients with acute respiratory distress syndrome receiving extracorporeal membrane oxygenation
title_short	Early measurement of IL-10 predicts the outcomes of patients with acute respiratory distress syndrome receiving extracorporeal membrane oxygenation
title_full	Early measurement of IL-10 predicts the outcomes of patients with acute respiratory distress syndrome receiving extracorporeal membrane oxygenation
title_fullStr	Early measurement of IL-10 predicts the outcomes of patients with acute respiratory distress syndrome receiving extracorporeal membrane oxygenation
title_full_unstemmed	Early measurement of IL-10 predicts the outcomes of patients with acute respiratory distress syndrome receiving extracorporeal membrane oxygenation
title_sort	early measurement of il-10 predicts the outcomes of patients with acute respiratory distress syndrome receiving extracorporeal membrane oxygenation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/40baa0b602b9426091818e30e90cbeb1
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Early measurement of IL-10 predicts the outcomes of patients with acute respiratory distress syndrome receiving extracorporeal membrane oxygenation

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