Foveal atrophy and macular hole formation following intravitreal ranibizumab with/without photodynamic therapy for choroidal neovascularization secondary to age-related macular degeneration

Pukhraj Rishi, Nachiappan Kasinathan, Chinmaya SahuShri Bhagwan Mahavir Vitreoretinal Services, Sankara Nethralaya, 18 College Road, Chennai-600006. Tamil Nadu, IndiaBackground: To report the occurrence of foveal atrophy and macular hole formation following intravitreal ranibizumab with or without p...

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Autores principales:	Pukhraj Rishi, Nachiappan Kasinathan, Chinmaya Sahu
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/40baaca4b50e4dbf9286c613c5b79712
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spelling	oai:doaj.org-article:40baaca4b50e4dbf9286c613c5b797122021-12-02T02:28:12ZFoveal atrophy and macular hole formation following intravitreal ranibizumab with/without photodynamic therapy for choroidal neovascularization secondary to age-related macular degeneration1177-54671177-5483https://doaj.org/article/40baaca4b50e4dbf9286c613c5b797122011-02-01T00:00:00Zhttp://www.dovepress.com/foveal-atrophy-and-macular-hole-formation-following-intravitreal-ranib-a6305https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Pukhraj Rishi, Nachiappan Kasinathan, Chinmaya SahuShri Bhagwan Mahavir Vitreoretinal Services, Sankara Nethralaya, 18 College Road, Chennai-600006. Tamil Nadu, IndiaBackground: To report the occurrence of foveal atrophy and macular hole formation following intravitreal ranibizumab with or without photodynamic therapy for choroidal neovascularization caused by age-related macular degeneration.Methods: This was a retrospective, interventional case series, in which 78 eyes of 76 patients were treated for wet age-related macular degeneration between February 2007 and August 2007. Of these, three eyes developed foveal atrophy following treatment. Two eyes underwent combination photodynamic therapy and intravitreal ranibizumab, and one eye underwent intravitreal ranibizumab alone. One of the two eyes that underwent combination therapy progressed to develop a macular hole.Results: On the first follow-up visit, all three eyes showed thinning of the fovea on optical coherence tomography. Subsequently, treatment was continued with repeat intravitreal ranibizumab injections. At the last follow-up, although choroidal neovascularization regressed in all eyes, extensive foveal atrophy developed in two eyes with macular hole formation in one eye.Conclusion: The possibility of foveal atrophy and macular hole formation must be borne in mind before initiating ranibizumab in combination with or without photodynamic therapy. However, larger studies with longer follow-up are required to understand such adverse effects better.Keywords: age-related macular degeneration, choroidal neovascularization, macular hole, foveal atrophy, photodynamic therapy, ranibizumab&nbsp; Pukhraj RishiNachiappan KasinathanChinmaya SahuDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2011, Iss default, Pp 167-170 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Pukhraj Rishi Nachiappan Kasinathan Chinmaya Sahu Foveal atrophy and macular hole formation following intravitreal ranibizumab with/without photodynamic therapy for choroidal neovascularization secondary to age-related macular degeneration
description	Pukhraj Rishi, Nachiappan Kasinathan, Chinmaya SahuShri Bhagwan Mahavir Vitreoretinal Services, Sankara Nethralaya, 18 College Road, Chennai-600006. Tamil Nadu, IndiaBackground: To report the occurrence of foveal atrophy and macular hole formation following intravitreal ranibizumab with or without photodynamic therapy for choroidal neovascularization caused by age-related macular degeneration.Methods: This was a retrospective, interventional case series, in which 78 eyes of 76 patients were treated for wet age-related macular degeneration between February 2007 and August 2007. Of these, three eyes developed foveal atrophy following treatment. Two eyes underwent combination photodynamic therapy and intravitreal ranibizumab, and one eye underwent intravitreal ranibizumab alone. One of the two eyes that underwent combination therapy progressed to develop a macular hole.Results: On the first follow-up visit, all three eyes showed thinning of the fovea on optical coherence tomography. Subsequently, treatment was continued with repeat intravitreal ranibizumab injections. At the last follow-up, although choroidal neovascularization regressed in all eyes, extensive foveal atrophy developed in two eyes with macular hole formation in one eye.Conclusion: The possibility of foveal atrophy and macular hole formation must be borne in mind before initiating ranibizumab in combination with or without photodynamic therapy. However, larger studies with longer follow-up are required to understand such adverse effects better.Keywords: age-related macular degeneration, choroidal neovascularization, macular hole, foveal atrophy, photodynamic therapy, ranibizumab&nbsp;
format	article
author	Pukhraj Rishi Nachiappan Kasinathan Chinmaya Sahu
author_facet	Pukhraj Rishi Nachiappan Kasinathan Chinmaya Sahu
author_sort	Pukhraj Rishi
title	Foveal atrophy and macular hole formation following intravitreal ranibizumab with/without photodynamic therapy for choroidal neovascularization secondary to age-related macular degeneration
title_short	Foveal atrophy and macular hole formation following intravitreal ranibizumab with/without photodynamic therapy for choroidal neovascularization secondary to age-related macular degeneration
title_full	Foveal atrophy and macular hole formation following intravitreal ranibizumab with/without photodynamic therapy for choroidal neovascularization secondary to age-related macular degeneration
title_fullStr	Foveal atrophy and macular hole formation following intravitreal ranibizumab with/without photodynamic therapy for choroidal neovascularization secondary to age-related macular degeneration
title_full_unstemmed	Foveal atrophy and macular hole formation following intravitreal ranibizumab with/without photodynamic therapy for choroidal neovascularization secondary to age-related macular degeneration
title_sort	foveal atrophy and macular hole formation following intravitreal ranibizumab with/without photodynamic therapy for choroidal neovascularization secondary to age-related macular degeneration
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/40baaca4b50e4dbf9286c613c5b79712
work_keys_str_mv	AT pukhrajrishi fovealatrophyandmacularholeformationfollowingintravitrealranibizumabwithwithoutphotodynamictherapyforchoroidalneovascularizationsecondarytoagerelatedmaculardegeneration AT nachiappankasinathan fovealatrophyandmacularholeformationfollowingintravitrealranibizumabwithwithoutphotodynamictherapyforchoroidalneovascularizationsecondarytoagerelatedmaculardegeneration AT chinmayasahu fovealatrophyandmacularholeformationfollowingintravitrealranibizumabwithwithoutphotodynamictherapyforchoroidalneovascularizationsecondarytoagerelatedmaculardegeneration
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Foveal atrophy and macular hole formation following intravitreal ranibizumab with/without photodynamic therapy for choroidal neovascularization secondary to age-related macular degeneration

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