Early Drug Discovery and Development of Novel Cancer Therapeutics Targeting DNA Polymerase Eta (POLH)

Polymerase eta (or Pol η or POLH) is a specialized DNA polymerase that is able to bypass certain blocking lesions, such as those generated by ultraviolet radiation (UVR) or cisplatin, and is deployed to replication foci for translesion synthesis as part of the DNA damage response (DDR). Inherited de...

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Autores principales:	David M. Wilson, Matthew A. J. Duncton, Caleb Chang, Christie Lee Luo, Taxiarchis M. Georgiadis, Patricia Pellicena, Ashley M. Deacon, Yang Gao, Debanu Das
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	fragment-based drug discovery (FBDD) structure-based drug discovery (SBDD) X-ray crystallography cancer therapeutics DNA damage response (DDR) polymerases Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/40bb23ee3ada4b41a46d7f5aa6c07ebc
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Early Drug Discovery and Development of Novel Cancer Therapeutics Targeting DNA Polymerase Eta (POLH)

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